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APHON
Overview Of Childhood Cancer
Question | Answer |
---|---|
What is cancer | genetic mutation (permanent DNA alteration, begins in single cell(Clonal)). |
Genetic mutation in CA results in 4 cellular changes: list | Lack of differentiation, loss of contact inhibition, unregulated growth, cellular immortality |
children at increased risk for CA (4) | GENETIC PREDISPOSITION (eg: downs, li-fraumeni, retinoblastoma gene) IMMUNODEFICIENCY (congenital/ acquired, treatment related) Hx OF CA, PRIOR CA TREATMENT |
Cancer is the number X cause of dealth in children | #2 |
2 broad classifications of childhood cancer | 1. hematological malignancies (Leukemia, lymphoma) 2. solid tumors (CNS tumor, Neuroblastoma, rhabdomysarcoma, wilms,ewings, osteosa |
Three layers of embryonic tissue | ectoderm (CNS & SNS (adrenal)) , mesoderm (blood, lympatics, bone, muscle, pleura, heart, kidney, gonads), endoderm (epithelium, GI tract, Thyroid). Most childhood cancers from mesoderm or ectoderm |
Common hematological cancers of childhood | Leukemia (blood/marrow) Lymphoma (lymph) |
Common solid tumors of childhood | CNS tumors (brain/spine) Neuroblastoma (SNS) Rhabdomyosarcoma (muscle) Wilms tumor (kidney) Ewing’s sarcoma, osteosarcoma (bone) Retinoblastoma (eye) |
Characteristics of Childhood Cancer | Usually affects deep tissues Often disseminated at diagnosis Sometimes related to peak growth periods No screening or early detection available Usually very responsive to therapy 75% overall cure rate |
Childhood Cancers with onset in infancy/ early childhood | Neuroblastoma Wilms tumor Retinoblastoma |
Childhood cancers with onset in adolescence | Hodgkin’s lymphoma Osteosarcoma |
Reason for improved survival in peds cancer | Clinical trials Multimodality therapy Intense supportive care Multidisciplinary approach |
Treatment modalities in childhood cancer | Chemotherapy Radiation Surgery Hematopoietic stem cell transplant Biotherapy |
Impact of childhood cancer | Loss of control Living with uncertainty Potential loss of future of child of future generations Developmental issues Family issues |
Year APHON formed | 1973 |