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Bug Drugs

Antibio vs Bugs

QuestionAnswer
Clindamycin (CleocinR)gram + S. aureus, S. epi, Streptococcus spp.
Clinda other Moderate B. fragilis & all other anaerobes (many strains have become resistant)
Trimethoprim / Sulfamethoxazole (BactrimR, SeptraR) gram + Good S. aureus, S. epi including most strains of MRSA, MRSE Good Streptococcus spp.; however, many (~50%) S. pneumo are now resistant NOT grp. D strep.
Trimethoprim / Sulfamethoxazole (BactrimR, SeptraR) gram - (Neisseria-resistance) Most gram negatives Including S. maltophilia NOT PSA
Trimethoprim / Sulfamethoxazole (BactrimR, SeptraR) other Chlamydia Nocardia Legionella NOT B. fragilis or other anaerobes
Rifampin gram + Good gram positive activity, incl MSSA, MSSE NOT grp D strep Often used in combination with PCN or vanco for synergy vs staph
Rifampin gram - Neisseria meningitides Variable activity against other gram negative organisms
Rifampin other M. tuberculosis
Flagyl other Trichomonas vaginalis OBLIGATE anaerobes only (including Excellent B. fragilis) No activity vs microaerophilic anaerobes
Zyvox Excellent MSSA, MSSE AND MRSA, MRSE Excellent Streptococcus spp. INCL PRSP, E. faecalis, E. faecium, VRE, VREF
tetracyclines gram + MSSA, MSSE, Streptococcus spp. NOT grp D strep
tetracyclines gram - N. gonorrhea (Note: the TCNs used to be more active against a broad range of gram negs, but now we have more potent, safer, cidal agents so generally these drugs are no longer used for the tx of gram negs except in rare circumstances)
tetracyclines other T. . pallidum (syphilis) Legionella spp. Rickettsia Chlamydia Mycoplasma Campylobacter B. fragilis (Doxy) Nocardia (Mino) Ureaplasma urealyticum
Created by: momolasa
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