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Fluid-Electrolytes r
Physiologic Mode
Question | Answer |
---|---|
Homeostasis | state of equilibrium |
Physiologic homeostasis: | state of balance within the body |
These changes have to be equalized for Fluid & Electrolyte balance to occure: | Water & various substances are constantly passing into and out of the body |
45-75% of body fluid is? | Water |
Primary body fluid and major solvent is? | Water |
Solutes? | particles or electrolytes and non-electrolytes |
Most important nutrient of life? | Water |
ICF-40% of body water? | Intracellular fluid |
ECF-Saline? | extracellular fluid - has two compartments. |
What maintains blood volume? | Water |
What regulates temperature? | Water |
What aids in digestion? | Water |
Which solutes have electrical charge to them (-/+) and are measured in mEq/L? | electrolytes. |
75% of extracellular fluid? | Interstitial fluid - in between cells, bathes cell, includes lymph. |
25% of extracellular fluid? | Intravascular fluid - plasma, liquid part of blood (contains leukocytes, erythrocytes & platelets) = 3 Liters. |
1 Liter of fluid = 1 Kg of body weight = ? | Equals to 2.2 pounds. |
What does sudden increase in weight might indicate? | Sudden increase in weight probably means fluid gain & usually happens to cardiac or kidney patients. |
First fluid spacing means: | normal distribution of fluids. |
Second fluid spacing means: | abnormal accumulation of interstitial fluid (edema). |
Third fluid spacing means: | fluid trapped & cannot easily move back into ECF (that's edema associated with burns or ascites). |
What active chemicals are present in all body fluids? | Electrolytes. |
What separates fluids in different compartments? | semi-permeable membrane. |
Why does change in one compartment produces change in other compartments of the body fluids? | Because body always tries to maintain homeostasis (balance). |
Fluids have different components in each compartment. | True. |
How many solute types are there? | Two. |
How many electrolyte types are there? | Two. |
First solute type is? | non-ionized substances (glucose, creatinine, urea). They have no electrical charge when dissolved in a solution. |
Second type of solutes are? | electrolytes: potassium, sodium, chloride - they carry an electrical current & dissociate into ions when dissolved in a solvent. |
Define two types of electrolytes: | cations+ = possitive charge anions- = negative charge |
Primary IC cation is: | Potassium (K+) |
Primary EC cation is: | Sodium (Na+) |
Primary IC anion is: | Phosphate (PO4-) |
Primary EC anion is: | Chloride (Cl-) |
What are two identical composites of ECF compartments? | 154 cations + 154 anions = 308mEq/L |
In what way are the two ECF compositions different? | Intravascular fluid has proteins which cannot pass thru the capillary walls, but interstitial fluid doesn't have those proteins. |
What is the smallest protein molecule that holds the fluid in the vascular space? | albumin |
Chem 7 OR (SMA7) OR BMP | test of electrolytes => Na|Cl|Gluc|creatinine (0.7-1.2)|K+|CO2|BUN |
What does BUN indicate? | hydration of the body |
Define concentration of body fluids: | it's determined by the number of particles dissolved in a unit of solvent & is expressed as OSMOLARITY (the number of milliosmols per liter of fluid (mOsm). |
What osmolarity do ICF and ECF have? | Both have osmolarity of approximately 300mOsm/L. |
What terms are used interchangeably? | osmolarity and osmolality |
What determines osmolarity? | it's determined by weight or how how many particles are there. Serum osmolarity reflects total body hydration. |
What determines osmolality? | it's determined by volume. |
Do solutes and fluids move from compartment to compartment? | Yes, they move to meet metabolic needs, acid-base disturbances & in response to drug therapy. |
What are two transport systems? | Active and Passive. |
Define Active transport system? | It requires energy (ATP) to Pump particles (ex. Sodium or Potassium) across cell membranes from levels of low concentration to high concentration. |
What is Passive transport system? | No energy needed to transport particles. Instead it uses processes of osmosis, diffusion, & filtration to transport. |
Define Osmosis: | Water goes to salt = movement of fluid from an area of lesser solute concentration to an area of greater solute concentration. |
Define Diffusion: | The movement of solute from an area of greater solute concentrationto an area of lesser solute concentration. |
Define Filtration: | the movement of water and small particles by hydrostatic pressure. |
Define Osmotic Pressure: | Drawing or pulling of water, depends on the number of molecules in the solution. A solution with a high solute concentration has a high osmotic pressure. |
What are the two divisions of osmotic pressure: | crystalloid & colloid |
Define crystalloid: | non-proteins = dissolved ions that can pass through a membrane. |
Define colloid: | gelatinous substances which do not pass through a membrane because they are bigger (ex. plasma proteins). |
What's a good friend of Albumin? | Calcium = it behaves like albumin - if albumin is low, calcium will also be low. |
Define albumin: | It's a smallest blood plasma protein. |
What does albumin affect? | It affects osmotic pressure of blood by exerting a colloid osmotic pressure or oncotic pressure which tends to keep fluid in the capillaries. |
What should you do if the albumin levels are decreased? | assess the patient for edema (it means that the fluid leaks out of capillaries into the interstitial spaces). |
Define Iso-osmolar: | it has same osmolarity as body fluids. Patients with hypovolimia or low blood pressure are given these kind of fluids. |
Define hypo-osmolar: | Less osmolarity than body fluids - solution will cause cells to inlarge. So, fluids shift from intravascular to interstitial <- inside of cells. |
Define hyper-osmolar: | greater osmolarity than body fluids - given to edema patients to move interstitial fluid to intervascular space. |
Define isotonic: | solution with the same osmolarity as the cell interior. |
What will hypotonic solution do? | it will increase cell's volume because this solution has a lesser concentration of solutes than the cell interior. |
What will hypertonic solution do? | will decrease cell's volume because this solution has a greater concentration of solutes than the cell interior. |
Define Iso-osmolar fluid deficit: | decreased body water & electrolytes. EC fluid remains iso-osmolar but volume decreases. |
What will be assessment findings in case of iso-osmolar fluid deficit? | hypotension, increased pulse & respiratory rate, cool skin, delayed vein filling, decreased urine output & shock can develop. |
How would you treat a patient in case of iso-osmolar fluid deficit? | replace losses with water and sodium (0.9%NS, isotonic). |
Define hyper-osmolar fluid deficit: | more of a decrease in body water than electrolytes. Water moves out of the cells to dilute ECF. |
What will be assessment findings in case of hyper-osmolar fluid deficit? | thirst, flushed skin, poor skin turgor, dry tongue, increased temp, increased Hct, increased BUN, and restlessness. |
How would you treat a patient in case of hyper-osmolar fluid deficit? | Replace water orally or I/V (5% D/W). |
Define hypo-osmolar fluid excess: | excess body water without excess electrolytes. Water moves into the cells causing them to swell. |
What will be assessment findings in case of hypo-osmolar fluid excess? | behavioral changes, confusion, sudden weight gain, warm moist skin, lethargy & convulsions. |
How would you treat a patient in case of hypo-osmolar fluid excess? | replace with hypertonic saline I/V (5%D & 0.9NS) and restrict water |
Define iso-osmolar fluid excess: | excess body water and sodium. The excess fluid moves into the extracellular spaces. |
What will be assessment findings in case of iso-osmolar fluid excess? | weight gain, edema of dependent parts (lower extremity and sacral area), pitting edema over body prominences, pulmonary edema, dyspnea, and cyanosis. |
How would you treat a patient in case of iso-osmolar fluid excess? | restrict salt, diuretics, elevate extremities & oxygen therapy. |
What does Hypothalamus regulate? | Thirst mechanism, but it doesn't work very well for elderly. |
What does Pituitary gland regulate? | It stores and secretes ADH (anti-diuretic hormone) and vasopressin which regulates water retention by the kidneys. |
What does Adrenal gland regulate? | secretes aldosterone (mineralocorticoid) and regulates sodium and potassium balance. |
What does Parathyroid gland regulate? | secretes PTH, which drops C++ levels & raises P- levels (inverse relationship). As PTH increases, Calcium reabsorption is increased & P- excretion is increased. So, if PTH decreases, then the process reverses. |
What does Lymphatic system do for regulation of Body Fluids? | It brings fluid back to the heart. |
What do Lungs do for regulation of Body Fluids? | They regulate Acid/Base balance. |
What do kidneys do for regulation of Body Fluids? | They respond to our blood volume. Also, they reabsorb and secrete Fluids and Electrolytes. |
In terms of kidneys and fluid regulation, what happens when blood volume drops? | Renal perfusion also drops, then kidneys release renin. Renin combines with angiotenogen to form Angiotension 1. |
What happens in the lungs with angiotension 1? | It's converted to angiotension 2. |
What does Angiotension 2 does? | It stimulates adrenal cortex to release aldosterone. Aldosterone directs kidneys to reabsorb Sodium; water follows Sodium back to ECF. |
What will decrease in cardiac output do to kidney perfusion? | It will decrease kidney perfusion. So, cardiovascular function maintains blood pressure to ensure adequate renal perfusion. |
What will be released from atrium when the heart is in fluid overload? | Atrial Natriuretic Peptide. |
What will Atrial Natriuretic Peptide do? | It will decrease fluid retention by blocking secretion and action of Aldosterone and inhibit renin secretion. |
Define Anasarca: | It's when organ systems are shutting down and fluid occumulates in all of the compartments of the body. Also known as "extreme generalized edema". |
Define term "Intake": | Normal 24hr Intake is 2500-3000ml. Intake comes from fluids we ingest, solid foods & from metabolism. Intake & Output should balance out. |
Define term "Output": | Normal 24hr fluid Output is 2500-3000ml. Output is through sensible & insensible losses. |
Define Sensible losses: | those that can be measured. Ex.: Urine, secretion of drainage tubes (wound drain or GI tube drain), or vomit=emesis |
Define Insensible losses: | those that cannot be measured. |
Define Insensible loses: | They cannot be accurately measured, ex.: perspiration (usualy 600ml), fluid lost with respiration (usually 300ml), fluid loss in feces (usually 100ml), fever & increased environmental temp, thus increased fluid loss thru lungs & skin. |
Signs & sypmtoms of (FVD) Hypervolemia (ECF excess) = Circulatory Overload: | Acute weight gain; ↑ interstial vol. (edema); ↑ vascular vol; ↑ JVD, pulmonary edema, SOB, tachypnea, crackles, cough, ↑ B/P, bounding pulse, confusion, lethargy, pitting edema; ↑ Na, Hct, BUN, urine specific gravity; ↓ O2 levels. |
Treatment of (FVD) Hypervolemia (ECF excess) = Circulatory Overload: | Watch Vital Signs & lung sounds often; Maintain IV access; Strict I & O; Fluid restrictions; Foley-hourly o/p; O2; Diuretics-daily weights; watch lab data; Watch for signs & symptoms of hypovolemia; watch cerebro-osmotic diuretics to prevent neuro-damage. |
Signs & sypmtoms of (FVD) Hypovolemia (ECF deficit) = Loss of fluids & solutes: | Change in mental status, anxiety, restlessness, thirst; tachycardia, delayed capillary refill, orthostatic B/P; Urine o/p<300ml/hr; cool, pale skin; weak or absent pulses; ↑ Hct, BUN, urine specific gravity. |
Treatment of (FVD) Hypovolemia (ECF deficit) = Loss of fluids & solutes: | Watch vital signs, lung sounds, & mental status; O2, watch ABG's, EKG; Maintain IV (isotonic=↑ bld vol); strict I&O, Foley-hourly if necessary; Daily wght; watch peripheral pulses & skin temp; change position slowly. |
Changes in which of the major cations IC will affect cardiac function? | Potassium (K+). |
What is the normal serum value for (K+)? | 3.5 - 5.0mEq/L |
List 4 major functions of (K+)? | regulation of all types of neuromuscular activity; aids in regulation of acid-base balance; maintains osmotic pressure of ICF; aids in promotion of cardiac muscle activity. |
What is the primary way thru which (K+) is regulated? | It is primarily regulated by kidneys (80%), although some excretion occurs via the feces (20%). |
When does K+ move into cells? | When glucose is metabolized. |
When does K+ move out of cells? | Via strenuous exercises; impaired cellular metabolism; or when cell dies. |
Values of Hyperkalemia? | serum K+ are above 5.0mEq/L = acidosis. |
Values of Hypokalemia? | serum K+ are below 3.5mEq/L = alkalosis |
K+ should never be administered at a rate greater than? | 10mEq/hour I/V. Use extreme caution when administering to patients with renal disease. |
What should you monitor for in patients with abnormal K+ levels? | Cardiac dysrhythmias. |
What is the major EC cation? | Sodium (Na+) |
What is the normal serum value for (Na+)? | 135-145mEq/L. |
List 4 major functions of (Na+)? | Generation & transmission of nerve impulses; regulation of osmotic pressure; aids in regulation of Acid/Base balance; regulates fluids in ECF. |
What is the primary way Sodium (Na+) is regulated? | Intake; aldosterone level; & urine output. |
Serum values for Hypernatremia? | Na+ above 145mEq/L = patient may actually halucinate. |
Serum values for Hyponatremia? | Na+ level below 135mEq/L. |
What do serum Na+ levels primarily indicate? | body water distribution. |
What is Osteomalacia? | It's softening of bones due to decrease in calcium & other necessary minerals. Calcium follows Vitamin D, thus Osteomalacia is usually caused by deficiency in Vitamin D, which in turn brings about demineralization of bones. |
What is distribution of Calcium (Ca+) would be like in a human body? | It can be found in ICF & ECF, 99% in bones & 1% in blood plasma. |
Normal serum values for Ca+? | 8.4-10.5mg/dl. |
What are the functions of Ca+? | Initiation of muscle contraction; aids in blood coagulation; aids in the formation of bones and teeth. |
How is Ca+ regulated? | It's primarily regulated by parathyroid (PTH). |
What is necessary for Ca+ absorption from the GI tract? | Vitamin D. |
Serum values for Hypercalcemia? | Above 10.5mg/dl. |
Serum values for Hypocalcemia? | Below 8.4mg/dl = may lead to tetany, which is a clinical neurological syndrome characterized by muscular twitching and cramps and (when severe) seizures. |
Describe Chvosek's sign: | tapping of the facial nerve elicits twitching of the nose, face or mouth. |
Describe Trousseau's sign: | inflation of B/P cuff for 1-5 min. elicits a spasm of the fingers and hand. |
Define positive Trousseau's or Chvosek's sign: | indicates neuromuscular excitability. |
What is Mg+? | Magnesium is an IC cation. |
Normal serum values for Mg+? | 1.3-2.1 mEq/L. |
What are the functions of Mg+? | It aids in carbohydrate (CHO) & protein metabolism; influences muscular activity; aids in clotting mechanism; produces cellular energy. |
How is Mg+ primarily regulated? | By kidneys. |
Serum values for Hypermagnesmia? | Above 2.1mEq/L. |
Serum values for Hypomagnesemia? | Below 1.3mEq/L. |
What is a major EC anion? | Chloride (Cl-). |
Normal serum values for Cl-? | 95-100mEq/L. |
What are the functions of Cl-? | Helps to maintain osmotic pressure; participates in maintaining water balance; participates in maintaining Acid-Base balance; participates in gastric digestion. |
How is Cl- primarily regulated? | Primarily by kidneys & according to Acid/Base balance, aldosterone secretion and dietary intake. |
Serum levels for Hyperchloremia? | Above 100mEq/L. |
Serum levels for Hypochloremia? | Below 95mEq/L. |
What is the major IC anion? | Phosphate (PO4-). |
Normal serum values for PO4-? | 2.5-4.5mg/dl. |
What are the functions of PO4-? | Aids in metabolism of carbohydrates (CHO), proteins, & fat; helps in maintaining Acid/Base balance; helps to store & transfer energy from one size in the body to another; helps to form bones. |
What primarily regulates PO4-? | The kidneys, parathormone & activated vitamin D. |
Ca+ & PO4- have a reciprocal relationship, thus increase in serum Ca+ levels will cause a: | decrease in the serum PO4-. |
Serum levels for Hyperphosphatemia? | Above 4.5mg/dl. |
Serum leves for Hypophosphatemia? | Below 2.4mg/dl. |
What is a major buffer within the body? | Bicarbonate (HCO3-). |
Normal serum values for HCO3-? | **Arterial = 22-26mEq/L(HCO3) **Venous = 24-30mEq/L(TCO2) |
What is a function of HCO3-? | Essential in the regulation of acid-base balance. |
How is HCO3- regulated in the body? | Primarily by the hemoglobin-oxyhemoglobin system, potassium-hydrogen exchange, & by the kidney & lungs physiologically. |
List 8 variables affecting Fluid & Electrolyte balance: | Age; Pregnancy; Older; Body size; Environmental temp; Diet; Stress; Exercise. |
How does age affect F&E balance? | Elderly take longer to correct F&E imbalances; decrease in kidney perfussion; usually have lower consumption of food; 2Gm Na+ diets (Na+ & H2O go together); ↓thirst. |
How does body size affect F&E balance? | Fat has less water; lean tissue (muscles) have lots of H2O. Females have more fat. |
What does ECF imply? | Pitting Edema. |
How would you assesss F&E imbalance? | History of F&E problems or renal disease; Diuretic use; Electrolyte supplements; Chronic diarrhea or excessive vomitting; Sudden weight gain. |
During inspection - what's the best indicator for fluid assessment? | Weight: (EC). 1L = 2.2lbs. |
During inspection - what does dyspnea EC/FVE (Fluid Volume Excess) indicate? | Pulmonary Edema. |
What are other signs of F&E imbalance upon inspection? | Edema (EC); neck vein distention (EC); mucous membranes dry; abdominal girth (EC)=3d spacing; intake & output=urine<30ml/hr. |
What does skin turgor indicate for Fluid Volume Deficit:Intracellular (FVD:IC) upon inspection? | pinch test; dehydration; B/P narrow; pulse pressure; increased temp; decreased pulse; sunken eyeballs; decreased tears. |
What lab results would you need to check for F&E imbalance? | -Na+, K+, Cl-, CO2- -PO4-, Mg+, Ca+ -BUN, protein, albumin -Hematocrit -serum & urine osmolarity (↑ if ECF) -Anion Gap -ABG's |
Would would confusion indicate upon inspection of (FVE/FVD)? | Neurological problem. Dizziness may also be a problem. |
What is orthostatic hypotension? | If B/P drops more than 20mm/Hg when rising from lying to upright position. B/P has to be measured in lying, sitting, and standing position to determine orthostatic hypotention. |
List possible nursing diagnoses for F&E imbalance? | Fluid Volume Deficit; Fluid Volume Excess; Risk for FVD; Risk for FVE; Impaired mucous membranes; Altered cardiac output. |
List desirable outcomes in case of F&E imbalance: | Balanced I/O; Urine output>30cc/hr; moist mucous membranes; No tenting or edema; normal electrolytes; 2+ pulses; normal B/P; no weight gain; no elevated temp. |
Possible interventions in case of F&E imbalance? | Watch B/P & HR; orthostatic hypotension; watch pulse strength; temp; weigh daily; assess mucous membranes q shift; skin turgor; I&O, especially urine output<30ml/hr; give diuretics or restrict fluids; admin. IV therapy; admin. electrolytes & watch results |
How does term pH used? | It refers to Acid/Base balance. |
What determines the acidity of the blood? | Hydrogen ions (H+) concentration. The number of ions H+ ions will determine the strength of the acid. |
What's the scale of pH? | pH of 1.00-7.00 = acidic pH of 7.00 = neutral pH of 7.01-14.00 = alkaline |
What do acids do to neutralize alkalosis? | They give up H+ ions. |
What do bases do to neutralize acidosis? | They accept H+ ions. |
How are Acid/Base measurements are done? | By measuring Arterial Blood Gases (ABG's). |
What is a principal alkaline substance in the plasma? | HCO3 = 22-26 (base). HCO3 < 22 = acidosis HCO3 > 26 = alkalosis |
ABG values? | pH < 7.35 = acidosis pH > 7.45 = alkalosis |
How is partial pressure exerted by the CO2 in arterial blood measured? | PaCO2 35-45 = normal PaCO2 < 35 = alkalosis PaCO2 > 45 = acidosis |
What is CO2? | It's an acid. |
How is carbonic acid formed? | CO2 combines with H2O in the blood to form it. |
What indicates partial pressure of O2 in the blood? | PaO2 = 80-100mmHg -> indicative of oxygenation, which is a respiratory parameter. |
What indicates amount of O2 bound to Hgb? | SaO2>95%. |
What is the function of chemical buffers in the blood (Hgb, proteins & HCO3)? | They are mechanisms to maintain Acid/Base balance. |
How do cells help in the process of maintanance of Acid/Base balance? | They soak up or release H+ ions. |
How can lungs help to maintain Acid/Base balance? | They will convert carbonic acid to CO2 & H2O, which is exhaled. Respiratory rate will adjust as needed. |
What will regulate the amount of HCO3 that is going to be reabsorbed? | Kidneys. |
What is acidosis? | It is the total number of buffer base has dropped below normal leaving a higher concentration of H+ ions. |
What causes acidosis? | It is cased by losing too much base or gaining too much acid. The ration of carbonic acid to carbonate increases (normal ration is 1:20), thus patiet's pH decreases below 7.35. |
What is alkalosis? | The total concentration of buffer base has increased or the total number of H+ ions has dropped. |
What causes alkalosis? | It's caused by gaining too much base or losing too much acid. The ratio of carbonic acid to bicarbonate decreases below 1:20, thus pH goes above 7.45. |
Name imbalance caused by an increase of PCO2: | Respiratory acidosis. |
Name imbalance caused by a decrease of HCO3: | Metabolic acidosis. |
What causes respiratory acidosis and what are the signs and symptoms of it? | Causes: Excess carbonic acid; COPD; drug overdose; hypoventilation. S/S: cerebral edema; decreased CNS activity; restlessness; confusion; anxiety; SOB; flapping tremors (asterixis). |
What causes metabolic acidosis and what are the signs and symptoms of it? | Causes: Bicarbonate deficit; sepsis; RF, starvation. S/S: headache, malaise, lethargy, EKG changes, CNS depression, NVD, hypotension, kussmauls respirations. |
What causes respiratory alkalosis and what are the signs and symptoms of it? | Causes: Carbonic acid deficit; pulmonary edema, hyperventilation. S/S: hypoxemia - deep rapid breathing>40; decreased cerebral blood flow - dizzy, agitated, circumoral & peripheral paresthesia, muscle weakness. |
Name imbalance caused by a decrease in PCO2: | Respiratory Alkalosis. |
Name imbalance caused by an increase in HCO3: | Metabolic Alkalosis. |
What causes metabolic alkalosis and what are the signs and symptoms of it? | Causes: Bicarbonate excess; overuse of antiacids; loss of gastric secretions. S/S: decreased cerebral perfusion - irritablity, picking at bedclothes, twitching, convulsions, seizures, hypokalemia, arrhythmias, slow respirations; trousseau's sign. |
What if patient's body compensates for Acid/Base imbalance? | The pH will be normal, but PCO2 or HCO3 will usually be slightly abnormal. |
Older adults are at increased risk for electrolye imbalances because with age kidneys have: | Fewer functioning nephrons. |
If you were walking along the Sahara Desert with an empty canteen, the amount of antidiuretic Hormone (ADH) secreted would be: | Increased. |
Which process requires energy to maintain the unique composition of extracellular adn intracellular compartments? | Active Transport. |
Hydrostatic pressure, which pushes fluid out of the capillaries, is opposed by colloid osmotic pressure, which involves: | The pulling power of albumin to reabsorb water. |
When a person's blood pressure drops, the kidneys respond by: | Secreting renin. |
The main extracellular cation is: | Sodium. |
PaCO2 level indicates the effectiveness of: | Lung ventilation. |
If your patient is breathing rapidly, his body is attempting to: | Get rid of excess carbon dioxide. |
Which body fluid lies in the spaces between the body cells? | Interstitial. |
The principle site for regulation of fluid & electrolyte balance is: | Kidneys. |
In a healthy adult, which of the following regulates body fluids? | Hormonal regulation, fluid intake, and kidney function. |
Chloride, bicarbonate, phosphate, and sulfate are examples of: | Anions, because they carry a negative charge. |
Identify the mechanism(s) involved in acid/base balance. | Buffer, respiratory, and renal. |
What is the correct term to describe a Potassium level of 6.0mEq/L? | Hyperkalemia. |
The nurse notes patient has had an elevated temp for two days, skin turgor poor, & dry mouth. What would the nurses best response be? | a. Call MD, request IV fluid bolus b. Place pt on I&O measurements c. Restrict fluid intake to 600ml for the rest of the shift d. Encourage pt to drink at least 1L of fluid during rest of shift. ← |
Which of the following patients is at high risk for developing a FVD? | a. 68 yr old male paralyzed from a stroke ← b. 23 yr old female with renal failure c. 13 yr old male playing chess d. 83 yr old female with congestive heart failure. |