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What is the purpose of antifungal use
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What is the actions of antifungal
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68WM6 Ph 2 Test 3-AF

68WM6 Ph 2 Test 3-Anti-fungal

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What is the purpose of antifungal use 1)treatment of fungal infections 2)treats infection of mucous membranes with topical or vaginal preparation 3)treat deep-seated/system infections with oral or parenteral therapy 4)new forms of amphotericin use liquid encapsulation to decrease toxicity.
What is the actions of antifungal To kill (fungicidal) or stop growth of (fungistatic) susceptible fungi by affecting the permeability of the fungal cell membrane or protein synthesis within the fungal cell itself
Name the 2 categories of Antifungals 1)Systemic 2)Topical/Local
Name 3 types of Systemic Antifungals 1)amphtericin B cholesteryl sulfate (Amphotec):fungistatic or fungicidal, depending on the dosage. 2)fluconazole (Diflucan) 3)ketoconazole (Nizoral)
Name 3 types of Topical/Local Antifungals 1)butenafine (Lotrimin Ultra) 2)clotrimazole (Lotrimin) 3)ketoconazole (Nizoral) 4)miconazole (Litrimin AF, Maximum Strength Desenex/Monistat-Derm) 5)nystatin (Mycostatin) 6)terbinafine (Lamisil AT) 7)tolnaftate (Tinactin)
Antifungal Contraindications previous hypersensitivity
Antifungal Precautions 1)cautious use in pt with depressed bone marrow reserve. 2)Amphotericin B commonly causes renal impairment. 3)Fluconazole requires dosage adjustment for the renal impairment pt. 4)Adverse reactions to fluconazole may be more server in HIV-positive pt
Antifungal Side Effects/Adverse Reactions 1)Systemic a)CNS:headache b)GI:N/V/D c)F and E:hypokalemia 2)Topical/Local: burning, itching, local hypersensitivity reactions.
Antifungal Assessment 1)increased skin irritation may indicate need to discontinue medication 2)Monitor VS q 15-50min during 1st infusion, not changes in BP and pulse. 3)Decreased urine output/changes in specific gravity/>2lb/wk, stop use to prevent renal tubule damage.
Renal toxicity increased BUN (>40mg/dl), creatine (>3mg/dl). Drug may be disacontinued or dosage reduced.
Hepatotoxicity increased AST, ALT, alk phos, bilirubin
Opportunistic disease Some fungi are part of normal tissue(e.g.,Candia albicans). This is when the pt becomes infected with these organisms.
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