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hcr 240

pathophysiology ch1-20

QuestionAnswer
etiology the origin of disease;cause;risk factors
pathophysiology deals with cellular and organ changes that occur with disease, and the effects of such changes on cellular/organ/body structure and function(maladaptation).
pathogenesis the sequence of cellular and tissue events that take place from the time of initial contact with the etiologic agents until the ultimate expression of a disease.
morphological changes changes in the underlying structure or form of cells or tissues;both microscopic and grossly observable.
morbidity describes the effects of an illness has on a person's life
mortality statistics expressing death rates, often for specific diseases and specific populations
autocrine white blood cells(immune cells);signals itself
paracrine local communication,interstitial fluid;organ to organ.
endocrine distant communication
osmosis movement of water across membrane, from an area of lesser concentration to a greater concentration
diffusion gas and other substances move from an area of greater concentration to area of lesser concentration
facilitated diffusion carriers system to move large complex substances, such as glucose,across a membrane
active transport can move against a concentration gradient:takes energy to do this, and ATP such as in sodium and potassium pump
pinocytosis phagocytosis: intake of substances and organisms
exocytosis release from cell, release of hormones
endocytosis cells engulf materials from their surroundings
resting membrane potential low permeability, negative inside cell membrane
threshold potential when cell is stimulated to produce action potential
depolarization highly permeable to sodium ions;positive inside the cell membrane
repolarization polarity of resting potential is reestablished
epithelium is avascular, supported by basement membrane;for covering 1)skin,mucuous membranes(squamous, cuboidal,columnar;simple,stratified). 2)intracellular adhesion molecules(ICAMs) and cell juctions
atrophy decrease in size of body parts due to disease,denervation,lack of endocrine stimulation,decreased nutrition;ischemia and it is reversible
hypertrophy increase in size of body part, it is reversible
hyperplasia increase in number of cells
metaplasia change form one cell type to another
dysplasia cells with variation in size, shape and appearance
duration (time) and intensity of exposure (amount) determines whether cells are injured or successfully adapt
free radicals the presence of an unpaired electron in the open shell of an atom;causes instability/vibration
electron trnsfer system of mitochondria electrons are naturally passed between atoms/molecules to facilitate biochemical processes
human genome project exact number of genes in humans remains undetermined
protein-coding genes every gene determines the function for each individual protein
genes make up the structure of amino acids which in turn determines the pattern of folding for each protein, thus,controlling the actual function of the protein
DNA genetic code;G,C,T,A;thought of as a'cookbook'
RNA compliment of code and mobile;G,C,A,U;thought of as the 'recipes'
transcription DNA----mRNA
translation rRNA---proteins
hereditary genetic
congenital present at birth;birth defects
reactive oxygen species (ROS) superoxide radical(hydrogen peroxide), singlet oxygen oxygen atoms, hydroxyl molecules(0H)
free radical scavengers (antioxidants) pick up/ give up single electrons and yet remain stable (terminating the chain-reaction)
single gene disorders autosomal dominant:50% chance of transmitting disorder form parent to child.e.i. 1-familial hypercholesterolemia:too much cholesterol in bloodstream. 2-adult polycystic kidney disease(AD-PKD):4th leading cause of CRF(chronic renal failure)
autosomal recessive form both parents.examples: 1-cystic fibrosis:thick, dry mucous buildup in the lungs 2-sickle-cell disease:red blood cells become sickle shaped caused by a single amino acid out of place.
sex-linked recessive mother to son(x-linked)..example 1-G6PD deficiency:#1 human enzyme defect
polygenic disorders 20% of all births defects;not as survivable/common a)multifactorial inheritance
chromosome disorders 6% of all birth defects ..example 1)trisomy 21-down syndrome:mosaic patterns:example(1/3 cells have trisomy 21,2/3 normal)
environmental agents diabetes mellitus, smoking,alcohol,radiation.Most vulnerable period is 15 days-8 weeks after conception
anaplasia lack of cell differentiation
loss of density dependent growth
loss of cohesiveness (cellular adhesion molecules)
apoptosis cells do not die 'on time'
doubling time time for the total mass of cells in the tumor to double.Big enough to palpate:after doubling 30 times(1 billion cells).After doubling 5 more times tumor is fatal
benign cancer cells are not necessarily damaging. They take pauses when copying themselves.Form a basement membrane around themselves with adhesion molescules(not mobile).Cells tend to wrap around clusters of cranial neurons.Worst in the brain because of intercranial
malignant cancer cells are extremely damaging. Wholly undifferential cells.Do not attach to any other cells (very mobile)
hyperthermia---heat cramps a distribution problem between salt loss and electrolytes
hyperthermia---heat exhaustion a problem with a loss in volume
hyperthermia--heat stroke usually a response to prolonged elevated environmental temperatures, body temperatures that exceeds 105-105 F
osmotic force excess sodium and urea causes more water in the blodstream(hyperosmolar)
oncotic protein/albumin
bronchial asthma manifestations bronchospasms,edema,mucus production,vary chest tightness,prolonged expiration,fatigue,wheezes,dyspnea.severe and prolonged:respiratory failure.
emphysema pathogenesis: inflammatory process and fibrosis,excessive mucus production,loss of alveolar tissue,loss of ventilation and perfusion.
bronchiectasis coughing,fever,recurrent infections,expectoration of foul-smellimg,purulent sputum,cupfuls.
cystic fibrosis pancreatic insufficiency (malabsorption,stearrhea),lung(thick,mucus,leads to mucus plugs).
pulmonary embolism blood borne substance lodges in branch of pulmonary artery;thrombus;air,fat,amniotic fluid.
pulmonary embolism manifestation abrupt in onset,apprehension,chest pain and dyspnea,distended neck veins,cyanosis,diaphroresis,shock,syncope,mental confusion
Created by: ammunoz3
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