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Hypertension
Intro to Pharm. HTN
Question | Answer |
---|---|
Normal Blood Pressure | <120 /<80 |
Prehypertension | 120-139 / 80-89 |
Stage I Hypertension | 140-160 / 90-99 |
Stage II Hypertension | >160 / >100 |
Diuretics | The diuretic act as antihypertensive agent by causeing volume depletion, sodium ecretion, and vasodilation of peripheral arterioles. |
Beta-Adrenergic Blocking Agents | Combine reversibly with beta-adrenergic receptors to block the response to sympathetic nerve impulses, circulating catecholamines, or adrenergic drugs. |
Angiotensin-Converting Enzyme Inhibtors (ACE) | Believed to act by suppressing the renin-angiotensin-aldosterone system. Renin, synthesized by the kidneys, produces angiotensin I, an inactive decapeptide derived from plasma globulin substrate. |
Angiotensin II Receptor Blocker | Angiotensin II, a potent vasoconstrictor, is the primary vasoactive hormone of the renin-angiotensin system; it is involved in the pathophysiology of hypertension. Angiotensin II increases systemic vascular resistance, causes sodium and water retention, a |
Calcium Ion Antagonists | For contraction of cardiac and smooth muscle to occur, extracellular calcium must move into the cell through openings called calcium channels. The calcium channel blocking agents (also called slow channel blockers or calcium antagonists) inhibit the influ |
Alpha-1 Adrenergic Blocking Agents | Selectively block postsynaptic alpha-1-adrenergic receptors. Results in dilation of both arterioles and veins leading to a decrease in supine and standing BP. Diastolic BP is affected the most. |
Central-Acting Alpha-2 Agonists | Stimulates alpha-adrenergic receptors of the CNS, which results in inhibition of the sympathetic vasomotor centers and decreased nerve impulses. Thus, bradycardia and a fall in both SBP and DBP occur. |