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RA drugs
Med Surg III
Question | Answer |
---|---|
DMARDS | methotrexate Rheumatrex, Trexall |
DMARDS | penicillamine Cuprimine, Depen |
DMARDS | sulfasalazine Azulfidine, Salazopyrin |
DMARDS | leflunomide Arava |
Antimalarial | hydroxychloroquine Plaquenil |
Biologic Targeted Therapy | etanercept Enbrel |
Biologic Targeted Therapy | infliximab Remicade |
Biologic Targeted Therapy | adalimumab Humira |
Biologic Targeted Therapy | anakinra Kineret |
Biologic Targeted Therapy | abatacept Orencia |
Biologic Targeted Therapy | rituximab Rituxan |
methotrexate | rapid anti-inflammatory effect |
penicillamine Cuprimine, Depen | Inhibits T cell function, impairs antigen presentation. |
Sulfasalazine, Azulfidine Salazopyrin | Blocks prostaglandin formation |
leflunomide Arava | Inhibits proliferation of lymphocytes, blocks immune cell overproduction |
Hydroxychloroquine Plaquenil | suppress formation of antigens, inhibits lysosomal enzymes |
Etanercept Embrel | Engineered copy of the TNF cell receptor, Binds TNF before TNF can by to the cell surface receptor |
Infliximab Remicade | monoclonal antibody that binds to TNF |
adalimumab Humira | monoclonal antibody that binds to TNF reduces infilitration of inflammotory cells |
anakinra Kineret | blocks the action of interleukin decreased inflammatory response |
Abatacept Orencia | Modulates T cells activation, suppresses immune response |
Rituximab Rituxan | monoclonal antibody that targets b cells |
Gold compounds | alters immune response, inhibits T and B cell activity, suppressing synoviitis of active ra. |
Corticosteriods | inhibits synthesis/release of mediators of inflammtion |
methotrexate rheumatrex trexall | hepatoxicity, bone marrow suppression, nephrotoxicity sustained cough |
penicillamine Cupramine Depen | GI irritation, reduces alters taste, proteinuria, hamaturia, rash fe def anemia |
Sulfasalazine Azulfidine Salazopyrin | Gi effects, bleeding, bruising, jaundice, rash, HA, uticaria, purititis. Discoloration urine et skin. |