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antitubercular meds

ch. 11 roach's clinical pharm

QuestionAnswer
ethambutol, Myambutol not recommended for children younger than 13; used with caution in patients with hepatic/renal impairment, & with diabetic retinopathy or cataracts
isoniazid (INH), Nydrazid when taken with foods containing tyramine & alcohol an exaggerated sympathetic type response can occur (hypertension, increased heart rate, palpitations)
pyrazinamide hepatotoxicity is main adverse rxn seen; contraindicated in gout & severe hepatic damage; decreased effectivenes w/ antigout meds; can cause myalgia
rifabutin, Mycobutin used for myobacterium avium; can cause discolored urine
rifampin, Rifadin/Rimactane can cause reddish orange discoloration of body fluids (urine, tears, sweat, sputum), vertigo,GI upset
rifapentine, Priftin can cause hyperuricemia, proteinuria, hematuria, lymphopenia
isoniazid: most common symptom of toxicity peripheral neuropathy; severe hepatitis may appear after many months of treatment
Created by: 740329098
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