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Immune System

Nursing Anesthesia:Immune System

QuestionAnswer
3 functions of the immune system Defense of foreign pathogens/infecttion, Homeostasis - helps clean blood, Surveillance for CA
Naturally Active Immunity acquired through encounter live pathogen and have a primary immune response
Naturally Passive Immunity mother's breastmilk, placenta (IgG)
Artifical Passive Immunity Injection of gamma globulin
Artifical Acquired Immunity (artificial) vaccination
B Cells made where? made in bone marrow
T Cells made where? made in thymus (Long-term immunity)
Humoral Immunity B-Cells - Antibodies
IgG only one to cross the placenta
IgA breast milk and most body secretions
IgM Involved in Primary immune response
IgD on B-Cells
IgE Involved allergies Remember IgE - Eosinophils which release histamine
Primary Immune Response (First Exposure) the first contact witht the Antigen - activation of B-cells to Plasma that release Antibodies and Memory Cells
Secondary Antibody Response (Second Exposure) Happens quicker, 1-2 days with 2nd encounter.
B Cellst turned into... plasma cells -> antibodies
In cell- mediated immunity Primary T Cells against.... INTRAcellular infections,viruses, tumors, tissue rejections
B Cells against... Extracellular, found in body fluids,and indirectly become Plasma cells producing antibodies
The complement system (the Antigen-Antibody Interactions) ChemotaxisDiapedsis - basically increase vasc. permeablityAgglutinationOpsonizationLysis
Opsonization coated outside of cells, made it more suspectible to phagocytosis
Lysis damaging the cell member, killing the cell
Chemotaxis Attracting and keep phagocytes in the inflam area
T Lymphocytes (cytotoxic T Cells) attack cells that they want to kill
Substances that help reconized self from non-self MHC (Major histocompability complex)&HLA (Human Leukocyte Antigen)
Natural Killer Cells Kill cells directly
Nonspecific Immunity includes... Mechnical defenses/barriers, enzymes, inflammation, cellular response, species resistance
Reticuloendothelial Tissue where your phagocytic cells wait and already action when needed. These include the blood, lymph, vessel lining, liver, spleen, bone marrow
Anaphylactoid Occur in immediate hypersensitivity allergic reactions. Occurs in minutes. IgE attaches to mast cells; Chemical mediators (histamine,prostagladins,...) released
The most important activator of of inflammatory response The Mast Cells
Chemical Mediators Histamine, Serotonin, Prostaglandins
Kinins system involved bradykinins - increased vasc. permeability
Effects of mediator: Histamine Smooth muscle contraction; increased vascular permeability (edema); Vasodilation - vasoconstriction; Hypotension; Increased secretion of mucus; Itching
Anaphylactic Shock Life threatening; Bronchial constriction; Vascular collapse; Edema, Hives, itching progress rapidly to shock
What happen in delay-reaction allery repeated exposure, eventually sensitized T cells leading to skin inflammation & dermatitis
Ex of Type IV contact dermatitis, microbial hypersensitivity reactions, transplant rejection
Four categories of Allergens Inhalants, Contactants, Ingestants, Injectables
What should you assess for with Allergic Disorders? Family allergies; past/present allergies; course of response (what happens?); Integumentary system; EENT, Resp: wheezing, stridor, sputum
Diagnostic Studies for Allergic Disorders CBC with WBC differential
What is increased in allergic responses eosinophils
RAST Radioallergosorbent test
What does a RAST test? blood sample - safer - less risk to paattient - not as reliable - expensive
Skin tests Scratch/prick; Intracutaneous injecton (arms/back) Monitor closely and precautions must be taken
Anaphylaxis Treatment ABC's: Airway, oxygen; Tourniquet to prevent spread (above site); Epinephrine or antihistamines for a lesser reaction; Treat shock - replace fluids and give vasoconstrictors
What should you do when giving antibiotics or blood products observe carefully for s/s of a reaction - especially PCN & Cephalosporins;
Epinephrine sympathomimetic - stimulates sympathetic nervous system; dilates bronchials and constricts veins
Diphenyhdramine - Benadryl antihistamine
How is epi administered SC or IV
How is Benadryl administered IV, IM or PO
S/E of Antihistamines Drowsiness/sedation; decreased coordination
How do antihistamines work compete for H1 receptor sites with histamine; Don't prevent bronchospasms - WON'T HELP ANAPHYLATIC SHOCK
New Antihistamines do not cross blood-brain barrier and have less CNS effects - don't cause as much drowsiness
New antihistamines include Zyrtec, Hismanal, Claritin, Allegra
Sympathomimetic/decongestants Epinephrine; Phenylephrine (Neo-Synephrine); Pseudoephedrine (Sudafed)
Corticosteroids Nasal sprays for allergic rhinitis; Brief course of oral meds
Client teaching r/t drugs for allergies rebound s/e of nasal sprays - if used too much it makes the problem worse; s/e esp r/t safety
Ex of Antipruritic Drugs Topicals like calamine lotion, coal tar solutions camphor
Mast Cell Stabilizers Inhibit release of histamines, leukotrienes, etc.,; nebulizers, nasal spral oral
Ex of Mast Cell Stabilizers Cromolyn(Intal), Nedocromil (Tilade)
Immunotherapy is allergy shots
When is immunotherapy indicated for life threatening allergy (insect venom); used to control allergy when medications ineffective or allergen is unavoidable
Mechanism of action of immunotherapy block levels of IgE with higher levels of IgG by introducing small amounts of antigen that stimulate IgG response (substituting one for another)
Nursing Mgmt for Allergy Shots Observe pt for 20 min; watch for systemic reaction (potential-pruritis, urticaria, sneezing,etc.); given in controlled setting with emergecy equip, physician available
How should you administer an allergy shot aspirate - don't want to give into blood stream
For anaphylaxix after an allergy shot apply tourniquet above site
How and how often are allergy shots given SubQ and Q week
How long does it usually take for allergy shots to be effective 1-2 years
If having an anaphylaxis reaction to an allergy shot, you would administer... epinephrine
A latex allergy is mostly a Type IV because.... it is a contact dermatitis; usually a reaction to chemical; delayed reaction affects the skin only
A Type I Latex allergic reaction occurs within minutes; ranges from skin redness to anaphylactic shock
Management of Latex Allergies ID risk factors: asthma, other allergic reactions, HCW
Autoimmune Disorders are considered Type II & III reactions
What happens in autoimmune disorders inappropriate response to self-proteins; autoantibodies & autosensitized T cells
Autoimmune disorders tend to cluster - usually have more than one
Examples of autoimmune disorders autoimmune hemolytic anemia, Systemic lupus erythematosis, rheumatoid arthritis, scleroderma
HLA Human Leukocyte Antigen System (tissue compatibility)
What does HLA do used in matching donor tissue for transplantation; also a marker for genetic studies - relationship between autoimmune disorders and HLA types
Tx for autoimmune disorders include Apheresis, Plasmapheresis, and Immunosuppressants
Apheresis separation and removal of blood components
Plasmapheeresis (plasma exchange) removal of plasma containing components causing disease
Immunodeficiency Disorders cause an impairment of Phagocytosis, Humoral response, Cell-mediated response, Complement, and combined humoral and cell-mediated response (rem: the immune sys does not work)
Names of Primary Immunodeficiency Disorders Hypogammaglobulinemia, Agammaglobulinemia, and Acquired hypogammaglobulinemia
Hypogammaglobulinemia things you are born with - don't have enough of the protein to make antibodies; Defect; absence of one type (the boy in the bubble)
Agammaglobulinemia Bruton's Disease
Acquired hypogammaglobulinemia probably don't have enough - absence of plasma cells; recurrent infections
How do you treat acquired hypogammaglobulinemia with gamma globulin/plasma transfusion
How is gamma globulin therapy administered Previously given IM but now IV
What are examples when gamma globulin therapy is used for rabies and Hep B exposure
S/E of gamma globulin therapy flu-like symptoms, flank pain, chills, chest tightness, hypotension, slight temp increase, anaphylaxis with severe reactions
Nursing Mgmt of Gamma Globulin Tx Baseline wt, VS before administration; Pretx with aspirin, Benadryl; Sometimes Prednisone;
How is Gamma Globulin infused Slowly - no more than 3mL/min
What should you do if the patient is having s/e during administration of gamma globulin slow the infusion rate - DO NOT Stop unless anaphylaxis
DiGeorge's Syndrome lack of thymus/parathyroid development - absence of T cell function (hereditary)
Signs of DiGeorge's Syndrome recurrent viral, fungal, protozoan infections; Hypocalcemic tetany (Calcium)
Tx of Hypocalcemic tetany administration of calcium/VitaminD
Tx of DiGeorge's Syndrome fetal thymic transplant in utero
Severe Combined Immunodeficiency Disease B & T cell abnormalities;severe infections of all type
What is the onset of Severe Combined Immunodeficiency Disease Within the first 2 years of life
What is the tx for Serve Combined Immunodeficiency Disease Antibiotic therapy and protective isolation; Bone marrow transplant
What are the causes of Secondary Immunodeficiency Disorders Drug-induces: antineoplastic agents, corticosteroids; stress; age; malnutrition; radiation; loss of lymph nodes, thymus or spleen via surgery; Hodgkins; Viruses
Graft -vs- Host Disease Occurs with transfusion or transplant; graft rejects the host
What is the onset of graft vs. host for transplants 7-30 days post transplant
What happens in Graft vs Host disease Donor T cells attack host cells
What are the target organs of graft vs host skin, liver, GI tract
What are some of the s/e of graft vs host infection; interstitial pneumonitis
Mononucleosis Benign, self-limiting
What are the usual age to get mono 14-18 years
What can Mono lead to Epstein Barr virus (EBV)
What is the incubation period for Mono 4-8 weeks
What are the s/e of Mono during the prodromal phase: HA, fatigue, chills, anorexia, puffy eyelids
What are the symptoms during the Acute phase of Mono fever, painful lymph nodes, enlargement, sore throat
How do you Dx Mono mono-spot test
How do you Tx Mono Rest; treat symptoms
What occurs during Mono Leukocytosis, increased lymphocytes and monocytes
Chronic Fatigue Syndrom occurs during what age 25-45
What viruses could cause Chronic Fatigue Syndrome EBV, Herpesvirus, cytomegalovirus, ? cytokines
Chronic Fatigue Syndrome is often accompanied by depression
Clincal manifestations of Chronic Fatigue Syndrome overwhelming fatigue that is not r/t exertion; not alleviated by rest and affects life; Memory/concentration is impaired; sore throat, lymphadenopathy, muscle pain, joint pain, HA
Management of Chronic Fatigue Syndrome Supportive Care, NSAID's, antidepressants, Klonopin for sleep; walking program; psychosocial support
Dx of Chronic Fatigue Syndrome done by ruling out other disorders - no specific test
Created by: okrecota
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