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TL Non Cats

noncatecholamines

QuestionAnswer
Name some general therapeutic effects that can be achieved with noncatecholamines. local or systemic constriction of blood vessels; nasal and eye decongestion; dilation of bronchioles; smooth muscle relaxation
What is the main therapeutic effect of phenylephrine? local or systemic constriction of blood vessels
Name some drugs used for bronchodilation. albuterol, salmeterol, levalbuterol
Name a noncatecholamine used for nasal decongestion. ephedrine
Name a noncatecholamine used for smooth-muscle (uterine) relaxation. terbutaline (brethine for asthma)
How are noncatecholamines eliminated from the body? in urine
Which type of andrenergic drugs can cross the blood brain barrier, catecholamine or noncatecholamine? Noncatecholamines
How are noncatacholamines metabolized? primarilary inactivated in the liver but also lungs, GI, and other tissues
Explain the difference in action between catecholamines and noncatecholamines. noncatecholamines can be direct, indirect, or dual action whereas catecholamines are primarilary direct acting
Name a direct-acting noncatecholamine that stimulates alpha receptors. phenylephrine
Name some noncatecholamines that stimulate beta 2 receptors selectively. albuterol, isoetharine, metaproterenal, terbutaline
Name a dual acting noncatecholamine. ephedrine
Which noncatecholamine would be useful to treat hypotension in cases of severe shock? phenylephrine
Which noncatecholamine is useful to stop preterm labor? terbutaline
What adverse interactions can take place between anesthetics (general), cyclopropane, and halogenated hydrocarbons if taken with noncatecholamines? cardiac arrhythmias and hypotension –especially with mainly beta 2 active noncatecholamines like terbutaline
What drug type can cause severe hypertension and even death if combined with noncatecholamines? Monoamine oxidase inhibitors
Why shouldn’t oxytocic drugs be combined with noncatecholamines? Oxytocic drugs that cause uterine contractions may be inhibited by terbutaline. Oxytocic drugs taken with other noncatecholamines can cause hypertensive crises or stroke.
What adverse interaction could result from the combination of tricyclic antidepressants and noncatecholamines? hypertension and arrhythmias
What kinds of drugs can slow excretion of noncatecholamines prolonging their duration of action? Urine alkalizers like acetazolamide and sodium bicarbonate
What are the adverse reactions of noncatecholamines (HRAITDIISHHPADCCPPF)? headache, restlessness, anxiety or euphoria, irritability, trembling, drowsiness or insomnia, incoherence, seizure, hyper/hypotension, palpitations, angina, dysrhythmias, cardiac arrest, cerebral hemorrhage, paresthesias, pallor/flushing
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