click below
click below
Normal Size Small Size show me how
N201: Test II
Pharmocological
Group | Drug | Pharm. Act. | Indications | Admin | Side Effects | Pt. Teaching |
---|---|---|---|---|---|---|
Seratonin Antagonists | Ondanestron (Zofran) | Blocks 5-HT3 serotonin receptor = no nausea | Nausea r/t pregnancy, chemo, cancer | PO 30-40 mins. before surgery or expected nausea | Headache, Dizziness, Diarrhea | No driving bc sedation |
Prokinetic | Metoclopramide (Reglan) | Dopamine Blocker, Increase tone of lower esophageal sphincter, Increases peristalsis | Nausea, Vomitting, Pt's w/reflux (moves things through) | IV or PO, usually 30 mins before meals | Sedation, diarrhea, dry mouth, Tardative dyskinesia | No alcohol or driving bc of sedation, Monitoe BP & hypotension |
Antihistamines | Dimenhydrinate (Dramamine) | Blocks histamine receptors in the inner ear and CTZ | Motion sickness | PO, IV, IM, Rectal | Sedation, Drowsiness, Dizziness, Dry mouth, constipation, Urinary retention | Teach about side effects |
Histamine2 Receptor Agents | Cimetidine (Tagamet) Famotidine (Pepcid) Ranitidine (Zantac) | Block histamine receptors to decrease acid in stomach (doesn't prevent reflux but increases pH) | Reflux, Gastic & duodenum ulcers | Admin w/or w/o food, don't admin antacids w/in 1 hr. of giving antagonist (effects absorption rate), IV must be given slowly or can cause bradycardia | Nausea, vomiting, diarrhea, constipation, Decreased WBC's (long term use), Tagamet: Seizures, Lower labido, Lethargy | Antacidseffect absorption rate of Antagonist, Smoking also interferes with absorption |
Proton Pump Inhibitors (PPIs) | Omeprazole (Prilosec) Lansoprazole (Prevacid) Pantoprazole (Protonix) Esomeprazole (Nexium) | Decreases the acids in the stomach | Reflux, duodenum & gastic ulcers | Empty stomach, usually 1x daily before breakfast | Nausea, vomiting, diarrhea, log term use = bone loss | Antacids do not oaffect absorption, ^vit D, ^ ca+, ^ excercise |
Mucosal Protectants | Sucralfate (Carafate) | Creates gel to coat stomach (good w/pt's already have ulcer) | Pt.'s w/ Ulcers | Empty stomach - wait 2hrs before/after meals or other meds - affects absorption | Constipation, nausea, diarrhea, dyspepsia | Teach pt how to take |
Antacids | Aluminum hydroxide (Amphojel) Calcium carbonate (Tums) Magnesium hydroxide (Milk of Magnesia) | Neutralize gastric acid | Ulcers and reflux | PO | Amphojel & Tums: Constipation Milk of Magnesia: Diarrhea | Know what other medications are being taken |
Prostaglandin E Analogs | Misoprostol (Cytotec) | Works to increase pH, protect against ulcer, allow adequate blood flow to the gastric wall | Prevents gastric ulcers from long-term NSAID use | Take w/meals while taking NSAID | Diarrhea, Ab pain, nausea; women uterine cramps, spotting | Do not take if pregnant - spontaneous abortion |
Laxatives | Psyllium (Metamucil) Methylcellulose (Citrucel) | Promotes large soft stool by absorbing water into intestines Stimulaes peristalsis | Bulk forming | PO | ||
Laxatives I | Mineral Oil Glycerin Suppository | Softens fecal matter and lubricates intestinal tract | Lubricant | PO, Rectal | ||
Laxatives II | Bisacodyl (Dulcolax) Senna (Senokot) | Irritates colonic epithelium by stimulating sensory nerve ending and increasing peristalsis; also pulls water into bowel | Stimulant | PO | ||
Laxatives III | Docusate (Colace) | Promotes incorporation of water into the stool, resulting in softer fecal mass | Fecal Softener | PO | More of a daily treatment, Could take 1-5 days for it to take effect | |
Laxatives IV | Osmotic agent: Polyethylene glycol and electrolytes (Colyte or Golytely) | Rapidly pulls water into colon | Give before surgery, clean out intestines/bowels | PO | Diarrhea | |
Dopamine Antagonists | Porchlorperazine (Compazine), Promethazine (Phenergan), Metoclopramide (Reglan) | Blocks Dopamine receptor in CTZ of brain | Prevents Nausea | PO, IV, Rectal, No IV Push | Muscle spasms, tremors, rigidity, hypotension, sedation, dry mouth, urinary retention, constipation | Encourage fluids, Make Pt. aware of side effects |