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N201: Test II
Vocabulary
Question | Answer |
---|---|
Tardative dyskinsia | Involuntary movement of jaw - call doctor immediately or could become permanent |
CTZ | Chemoreceptor trigger zone |
Serotonin Agents | Ondanestron (Zofran) |
Serotonin Action | Blocks the serotonin receptor in our brain that makes us feel nauseous when it's stimulated |
Metoclopramide (Reglan) | Dopamine & Prokinetic |
Dopamine Antagonists | Prochlorperazine (Compazine) Promethazine (Phenergan) Metoclopramide (Reglan) |
Dopamine Action | Blocks the dopamin receptor in our brain that makes us feel nauseous when it's stimulated |
Ondanestron | Zofran |
Metoclopramide | Reglan |
Promethazine | Phenergan |
Prochlorperazine | Compazine |
Prokinetic | Metoclopramide (Reglan) |
Prokinetic Action | Dopamine blocker Increase tone of lower esophageal sphincter Increase peristalsis |
Serotonin Admin | PO 30 - 40 mins. before Surgery or expected nausea |
Serotonin Indications | Nausea r/t pregnancy, chemo, cancer |
Serotonin Side Effects | Headache, Dizziness, Diarrhea |
Serotonin Teaching | No driving bc sedation |
Dopamine Indications | Prevents Nausea |
Dopamine Admin | PO, IV (slow-over 15 mins.), Rectal, No IV Push |
Dopamine Side Effects | Muscle spasms, tremors, rigidity Hypotension Sedation Dry mouth, urinary retention, constipation |
Dopamine Teaching | Encourage fluids Make Pt. aware of side effects |
Prokinetic Indications | Nausea, Vomitting, Pt's w/reflux (moves things through quickly) |
Prokinetic Admin | IV or PO, usually 30 mins before meals |
Prokinetic Side Effects | Sedation, diarrhea, dry mouth, Tardative dyskinesia |
Prokinetic Teaching | No alcohol or driving bc of sedation Monitor BP & hypotension |
Antihistamines | Dimenhydrinate (Dramamine) |
Dimenhydrinate | Dramamine |
Antihistamine Action | Blocks histamine receptors in the inner ear and CTZ - Prevents Motion Sickness |
Antihistamine Indications | Motion sickness |
Antihistamine Admin | PO, IV, IM, Rectal Give 30 mins prior to activity that causes sickness |
Antihistamine Side Effects | Sedation, Drowsiness, Dizziness, Dry mouth, constipation, Urinary retention |
Antihistamine Teaching | Teach about side effects |
Antiemetics | Seotonin Antagonists Dopamine Antagonists Prokinetic Antihistamines |
Seotonin Antagonists Dopamine Antagonists Prokinetic Antihistamines | Antiemetics |
Histamine2 Receptor Agents | Cimetidine (Tagamet) Famotidine (Pepcid) Ranitidine (Zantac) |
Histamine2 Receptor Agents Action | Block histamine receptors in stomach to decrease acid in stomach (doesn't prevent reflux but increases pH) |
Histamine2 Receptor Agents Indications | Reflux, Gastic & duodenum ulcers |
Histamine2 Receptor Agents Admin | Admin w/or w/o food, don't admin antacids w/in 1 hr. of giving antagonist (effects absorption rate) IV must be given slowly or can cause bradycardia |
Histamine2 Receptor Agents Side Effects | Nausea, vomiting, diarrhea, constipation Decreased WBC's (long term use) Tagamet: Seizures, Lower labido, Lethargy |
Histamine2 Receptor Agents Teaching | Antacids affect absorption rate of Antagonist, Smoking also interferes with absorption |
Cimetidine | Tagamet |
Ranitidine | Zantac |
Famotidine | Pepcid |
Proton Pump Inhibitors (PPIs) | Omeprazole (Prilosec) Lansoprazole (Prevacid) Pantoprazole (Protonix) Esomeprazole (Nexium) |
PPI Action | Decreases the acids in the stomach |
PPI Indications | Reflux, duodenum & gastic ulcers |
PPI Admin | Empty stomach, usually 1x daily before breakfast |
PPI Side Effects | Nausea, vomiting, diarrhea Long term use = bone loss |
PPI Teaching | Antacids do not affect absorption ^ Vit D ^ Ca+ ^ Exercise |
Omeprazole | Prilosec |
Lansoprazole | Prevacid |
Pantoprazole | Protonix |
Esomeprazole | Nexium |
Mucosal Protectants | Sucralfate (Carafate) |
Sucralfate | Carafate |
Mucosal Protectants Action | Creates gel to coat stomach (good w/pt's already have ulcer) |
Mucosal Protectants Indications | Pt.'s w/ Ulcers |
Mucosal Protectants Admin | Empty stomach - wait 2hrs before/after meals or other meds - affects absorption |
Mucosal Protectants Side Effects | Constipation, nausea, diarrhea, dyspepsia |
Mucosal Protectants Teaching | Teach pt how to take |
Antacids | Aluminum hydroxide (Amphojel) Calcium carbonate (Tums) Magnesium hydroxide (Milk of Magnesia) |
Aluminum hydroxide | Amphojel |
Calcium carbonate | Tums |
Magnesium hydroxide | Milk of Magnesia |
Aluminum hydroxide Action | Neutralize gastric acid |
Aluminum hydroxide Indications | Ulcers and reflux |
Aluminum hydroxide Admin | PO |
Aluminum hydroxide Side Effects | Amphojel & Tums: Constipation Milk of Magnesia: Diarrhea |
Aluminum hydroxide Teaching | Know what other medications are being taken |
Decreased Blood flow + Increased stomach acid = | Perfect environment for an ulcer |
Prostaglandin E Analogs | Misoprostol (Cytotec) |
Misoprostol | Cytotec |
Prostaglandin E Analogs Action | Works to increase pH, protect against ulcer, allow adequate blood flow to the gastric wall |
Prostaglandin E Analogs Indications | Prevents gastric ulcers from long-term NSAID use |
Prostaglandin E Analogs Admin | Take w/meals while taking NSAID |
Prostaglandin E Analogs Side Effects | Diarrhea, Ab pain, nausea Women: uterine cramps, spotting |
Prostaglandin E Analogs Teaching | Do not take if pregnant - spontaneous abortion |
What drug can cause a spontaneous abortion in women if taken during pregnancy? | Misoprostol |
Cancer of Oral Cavity Risk Factors | Alcohol/smoking Greater in Males >50yrs |
Cancer of Oral Cavity Pathophysiology | Lips, Tongue, Floor of mouth |
Cancer of Oral Cavity Clin. Manifestations | Painless lesion that doesn't heal |
Cancer of Oral Cavity Diagnostic Tests | Biopsy to confirm |
Cancer of Oral Cavity Treatment | Depends on type/extent |
Cancer of Oral Cavity #1 concern | Airway |
A stroke is the | 3rd leading cause of death in USA |
Up to 80% of strokes are | preventable |
Strokes are the leading cause of | long-term disability |
_______ are more likely to have a stroke. | Men |
_______ are more likely to die from a stroke. | Women |
Cerebrovascular Disorder | Any interruption of blood supply to brain causing CNS Functional abnormality |
Stroke | O2 supply to the brain is disrupted |
Stroke has 4x higher incidence in | left hemi-sphere |
"STR" | Can a person... Speak simple sentence? Talk? Raise both arms? |
"F A S T" | Facial Arms Speech Time |
Neuroplasticity | Neuron's ability to rearrange connections |
Brain adaption | brain saturated w/blood or deprived of O2 = find alt. pathways |
Transient Ishemic Attack (TIA's) | Cerebral ischemic event lasting < 24 hrs May even last just a few minutes No permanent neurological chgs. |
Evolving Stroke | Worsening of deficits over minutes Suggests widening area of ischemia |
Completed Stroke | Acute cerebral ischemic event w/deficits |
#1 risk factor for stroke | Hypertension |
TIA aka | "warning strokes" |
Blood clot temporarily clogs artery so part of brain doesn't get blood it needs | TIA |
S/S of TIA | Similar to stroke, usually last 1 or 2 mins. |
Ischemic Stroke | Obstruction of cerebral blood flow |
88% of all strokes are | Ischemic Stroke |
"Worst headache of my life" | Subarachnoid hemorrhage |
Receptive Aphasia | Person doesn't know what's going on |
Expressive Aphasia | Person knows what's going on, but can't express |
Broca's Area located in | Left hemisphere |
Controls tongue, lips, vocal cords & ability to phonate (form words) | Broca's Area |
Global Aphasia | Expressive & receptive aphasia |
Dysphagia | Difficulty swallowing |
Dysarthia | Impaired speech |
Ataxia | Gait disturbance |
Nystagmus | Rapid Eye Movements |
Hemianesthesia | Pain on one half of body that doesn't completely register |
Wernicke's Area | Can be in whichever hemisphere is dominant for pt. |
Recalls, recognizes & interprets words & other sounds in the process of "phonating" | Wernicke's Area |
Dmg. to Wernicke's Area (Temporal lobe of dominant hemisphere) | Inability to comprehend spoken or written words |
If a Pt. is newly diagnosed with Afib, do TEE test to see if | There are clots behind the heart |
Trans-esophageal echocardiogram | TEE test |
Tissue Plasminogen Activator (tPA) | Time of onset is known and < 3 hrs |
Pt not a candidate for tPA if | Pt is rcvg IV Heparin |
Angioplasty | Any endovascular procedure to reopen narrowed blood vessels & restore forward blood flow |
Atherectomy | Opens occluded, scarred or calcified vessels by removing atherosclerotic plaques with rapidly rotating drills |
Balloon angioplasty | Relies on the inflation of high-pressure balloons within blocked arteries to force open |
Laser & radiofrequency waves | Vaporize or ablate atheroscleroptic plaques |
Endovascular stents | Hold vessels open with expandable lattices inserted across narrowed section of the artery |
Cerebral Angioplasty | Coils surgically placed in cerebral vascular malformations to assure patency and prevent rupture (Aneurysm) |
Hemorrhagic Strokes | Vessel ruptures & bleeds into brain or spaces around brain |
Intracerebral Hemorrhage | Always hypertension related |
Craniectomy | Removal of part of the brain |
Craniotomy | Redirection - keep from getting to brain stem |
Subarachnoid Hemorrhage | Bleeding into subarachnoid space |
Arteriovenous Malformation | A tangle of blood vessels in the brain or on the surface of brain that bypasses norm brain tissue and diverts blood from arteries to the veins |
Mandibular Fractures Clin. Manifestations | Dull ache -> throbbing pain Restricted jaw movement |
Mandibular Fractures Diagnostic | X-ray or MRI |
Mandibular Fractures Treatment | Rigid plate fixation Bone grafting |
Mandibular Fractures Nurse Mngmnt. | #1 Airway #2 Nutrition |
Absent/ineffective peristalsis of distal esophagus Failure of esophageal sphincter to relax in response to swallowing | Achalasia |
Achalasia | Food cannot get into the stomach |
Achalasia Diet | Small frequent meals/soft/encourage fluids |
Achalasia Meds | Ca+ channel blockers relax sphincters |
Achalasia Pneumatic dilation | Balloon to try and open sphincter up |
Achalasia Esophagomyotomy | Enter esophagus & cut muscle fibers |
90% of Hiatal Hernias are | Sliding esophageal hernias |
sliding Hernia Manifestations | Heartburn Regurgitation Dysphasia Belching Reflux* |
Reflux Occurs w/sliding hernia because | Sphincter is NOT intact - food easily regurgitates into esophagus. |
Paraesophageal manifestations | Sense of fullness after eating Indigestion May be a symptomatic |
The sphincter in a paraesophageal hernia | Is still intact. |
Hiatal hernia complications | Strangulation |
Gastroesophageal Reflux Disease (GERD) | Backflow of gastric contents into esophagus |
Avoid these if you have GERD | High-fat diet Caffeine, tobacco, alcohol, spearmint, peppermint, carbonated bevs Eating 2 hrs before bed Tight clothing |
Meds for GERD | Antacids Histamine Receptor Blockers PPIs Prokinetic Agents |
Treatment of GERD | Nissen fundoplication |
Nissen fundoplication | Surgery to wrap stomach around esophagus = No reflux |
Barrett's Esophagus | Chgs cells in esophagus bc constant burning of lining from reflux -> pre-cancerous condition |
S/S Barrett's Esophagus | Same as GERD -> ppl usually don't know it's happening |
Barrett's Esophagus Diagnosis | Endoscopy |
Barrett's Esophagus Treatment | Minor cell chgs Photodynamic therapy (PDT) Prohylactic esophagectomy |
Photodynamic therapy (PDT) | Take out piece of esophagus & replace w/jejunum or part of stomach |
Risk factors for Cancer of Esophagus | Barrett's Alcohol Tobacco 3x more common in men |
Cancer of Esophagus Mgmnt | Radiation Chemotherapy Surgery (Esophagectomy) |
Gastritis | Inflamation of the stomach |
Gastritis Patho | Lining can become swollen & ulcerate Can cause perferation of lining = hemorrhage |
Acute Gastritis Clin. Manifest | Abdominal discomfort Nausea Vomiting |
Chronic Gastritis Clin. Manifest | Abdominal discomfort Nausea Vomiting Heart burn Pain |
Chronic Gastritis | Find the trigger |
The most common location for ulcers is | the duodenum. |
Peptic Ulcer Disease | Increased acid & decreased mucus allow acid to erode mucosal wall |
Peptic Ulcer Disease occurs in the | Stomach Pylorus Duodenum Esophagus |
Increase gastric acid production | Caffeine Smoking Alcohol Stress |
H. pylori | Bact will burrow into the lining allowing acid in to create an ulcer |
H. pylori requires | 2 different Ab's to cure |
Intractable Ulcers | Incurable Ulcers - (perform Vagotomy) |
Vagotomy | Cut Vagus nerve to decrease production of stomach acid - (incurable ulcers) |
Antrectomy - Billroth I | Take out lower portion of stomach to decrease stomach acid |
"Coffee Grounds" in stomach/vomit | Hemorrhage |
Peritinitis | Stomach leak out causing bacterial infection - sepsis |
Perforation complications can lead to | Peritinitis |
Any leakage into the abdominal cavity... | Requires Ab's |
Weight indications for surgery | BMI >40 or over 100 lbs overweight |
3 Categories of Bariatric Procedures | Malabsorptive Restrictive Combined Malabsorptive & Restrictive |
Rstrictive Surgery: | Reduces food intake Decrease in appetite Early satiety Control of stoma Craving control (Ghrelin) |
Laparoscopic Gastric Banding | Inflatable silicone band completely around upper portion of stomach |
Vertical Sleeve Gastrectomy (VSG) | 85% of stomach removed - shaped like small banana |
Gastric Bypass | Limits size of stomach and bypasses some of the small intestine |
Secretory Diarrhea | Bowel doesn't reabsorb water - it excretes water |
Osmotic Diarrhea | Pulling of water into the bowel |
Infectious Diarrhea | C-diff |
Antidiarrheals | Loperamide (Imodium) Diphenoxylate (Lomotil) |
Loperamide | Imodium |
Diphenoxylate | Lomotil |
Constipation | Abnormal infrequency or irregularity of defications Abnormal hardening of stools Retention of stool in rectum |
Chronic Constipation | <3 bowel movements/week for 12 weeks in a 12 month period |
Bulk forming Laxatives | Psyllium (Metamucil) Methylcellulose (Citrucel) |
Psyllium | Metamucil |
Methylcellulose | Citrucel |
Bulk forming Laxative Action | Promotes large soft stools by absorbing water into the intestines Stimulates peristalsis |
Lubricant Laxatives | Mineral oil Glycerin suppository |
Lubricant Laxative Action | Softens fecal matter and lubricates intestinal tract |
Stimulant Laxatives | Bisacodyl (Dulcolax) Senna (Senokot) |
Bisacodyl | Dulcolax |
Senna | Senokot |
Stimulant Laxative Action | Irritates colonic epithelium by stimulating sensory nerve ending and increasing peristalsis |
Fecal softener Laxatives | Docusate (Colace) |
Docusate | Colace |
Fecal softener Laxative Action | Promotes incorporation of water into the stool resulting in softer fecal mass More of daily treatment 1-5 days to take effect |
Osmotic Agent Laxatives | Polyethylene glycol and electrolytes |
Osmotic Agent Laxative Action | Rapidly pulls H2O into colon -> diarrhea out |
Common Hernia Locations | Inguinal Femoral Incisional Umbilical |
Volvulus - Mech. Obstruction | Twisting of the bowel - caused by congenital abnormality |
Intussusception - Mech. Obstruction | Tunneling of bowel (folds in on itself) |
Paralytic illeus - Functional obstruction | No blockage, lack of movement (caused by surgery) |
Diverticulum | Sac like pouches -> sigmoid colon, usually |
Diverticulosis | Multiple Diverticulum |
Diverticulitis | Food or infection stuck in diverticula & cause inflammation |
Diverticular Disease | Submucosal layers of the colon herniate through the muscular wall |
Diverticular Disease Complications | Peritonitis Abscess formation Fistulas Bleeding |
End-to-end anastomosis | Cut out bad bowel & reconnect |
Appendicitis | Food or infection gets lodged in the appendix |
Diarrhea is common in | Chrohn's Disease |
In Chrohn's Disease, constipation is | Occasional |
Blood in stool in Chrohn's Disease is | Occult Common |
Abdominal pain in Chrohn's Disease is | Typically mid-abdomen and right lower quadrant pain |
Fever in Chrohn's Disease is | Common |
Weight loss/growth failure in Chrohn's Disease is | Common May occur for many months to years before diagnosis |
Perianal disease in Chrohn's Disease is | Common for: Fistula/fissures Abscesses/skin tags |
Diarrhea in Ulcerative Colitis is | Common, often with urgency |
Constipation in Ulcerative Colitis is | Rare without obstruction |
Blood in stool in Ulcerative Colitis is | Very common |
Abdominal pain in Ulcerative Colitis is | Cramping pain, often with stools |
Fever in Ulcerative Colitis is | Rare |
Weight loss/growth failure in Ulcerative Colitis is | Rare |
It is rare to have Perianal disease with | Ulcerative Colitis |
Chrohn's disease... | often recurs after surgery |
Ulcerative colitis... | is curable with a colectomy |
Right hemisphere | right now, present pictures, sound, sight, smell |
Left hemisphere | past, future associate present with past to prepare future Broca's area - speech center |
Broca's area | Speech center, left hemisphere |
Magnetic Resonance Imaging | MRI |
Second largest part of brain Balance and coordination, assists in controlling body movements | Cerebellum |
Largest most advanced part of brain higher intellect, speech, movement, emotion, and integration or sensory stimuli | Cerbrum |
Handles automatic functions Respiration, heart rate, BP, arousal, wakefulness & attention | Brain Stem |
Artistic, creative, intuitive | Right hemisphere |
Logic, reasoning, linear | Left hemisphere |
Cerebral edema | any swelling of the brain |
Frontal lobes | Voluntary muscle movements |
Parietal lobes | regulate taste and touch |
Temporal lobes | regulate hearing & smell |
Occipital lobes | regulate vision |
3 ways Neurological Changes may affect the body | Structural Metabolic Drug Related |
Cardiovascular Respiratory Infection | 3 ways Neurological Changes may affect the body |
AEIOU Tips = A | acidosis, alcohol |
AEIOU Tips = E | epilepsy |
AEIOU Tips = I | infection |
AEIOU Tips = O | overdose |
AEIOU Tips = U | uremia |
AEIOU Tips = T | trauma |
AEIOU Tips = i | insulin |
AEIOU Tips = p | psychogenic |
AEIOU Tips = s | stroke |
Often, the first sign that a neurological event is already in progress | Restlessness |
Progressive dilation of pupils | increasing ICP |
Fixed pupils | very serious injury at midbrain or lower |
Corneal reflex is | unilateral or absent in coma |
Cheyne-stokes respirations mean that | lesion or injury is deep within cerebral hemispheres (death is usually imminent) |
CT Scan, MRI | Show displacement of brain structures |
EEG | studies brain's electrical activity |
Cerebral angiography | detects aneurysms, occluded vessels & tumors w/in cerebral arts/veins |
Transcranial Doppler | assesses cerebral blood flow |
Lumbar puncture | CSF detects blood, WBCs, meningitis |
The 2 essential things the brain needs to survive are | O2 & glucose |
Brain | 80% of skull's contents |
CSF | 10% of skull's contents |
Blood | 10% of skull's contents |
Hypercapnia | Increased cerebral vasodilation then increased blood flow then increased ICP |
Hypoxemia | Cerebral vasodilation, which raises ICP |
Vasodilator drugs | increase cerebral blood flow -> temp increased ICP (Nitroglycerin) |
Cerebral Perfusion Pressure | Pressure needed to perfuse brain cells |
Normal CPP | 70-100 mm Hg |
CPP < 50 | irreversible brain dmg |