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PARASCI_L6 Matching
irritants, emotional stress/anxiety, respiratory infections, endocrine changes, temperature/ humidity changes, coughing/laughing, genetic factors
intrinsic allergens
major component of inflammatory response, attracting more inflammatory mediators to increase the response
cytokines
reaction to internal non-allergic factors, no obvious role of allergen in inflammatory response, IgE synthesis
intrinsic (non-atopic) asthma
under sympathetic control
nor-adrenaline
begins in childhood, sensitivity to external allergens (typically on inhalation)
extrinsic (atopic) asthma
increase mucus secretion, further obstructing airway & causing more histamine release
leukotrines
chronic inflammatory disorder of the airways, with acute episodes of airway obstruction due to bronchospasm, mucosal oedema, excess mucus production
Asthma
under parasympathetic control
ACh
pollen, air pollution, animal dander, house dust/ mould, feather pillows, food additives, noxious fumes, tobacco smoke
extrinsic allergens
responsible for vasodilation and bronchospasm element
histamine
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