X-Phar410 Drug Bio Matching
| some inactive drugs that cause stomach upset can be matched up with enzymes in the liver that activate them |
| this helps keep the inactive form from stomach upset; it becomes active in the liver |
| derivative of drug structure; usually inactive or less active |
| in some cases biotransformation results in |
| an active form of the initially inactive parent drug |
| enterohepatic recirculation; occurs with Glucuronides of drug taht are formed in the liver; excreted in intestine via bile |
| a substance (drug) that stimulates synthesis of an enzyme; increases metabolic capacity for that isozyme is known as |
| must abundant subfamily of human cytochrome enzymes |
| increases amount of enzymes |
| inducers; leads to lower concentrations of the drug in the bloodstream |
| Phase II Glutathione conjugation |
| a tripeptide of glutamate, cysteine, and glycine that picks things up to help them be excreted |
| If a genetic defect in a CYP3A4 that made it inactive would result in? |
| No metabolism because enzyme doesnt work |
| CSH conjugation is catalyzed by |
| glutathione S- transferases |
0:00
