Chronic Lymphoproliferative Disorders
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| show | 2:1
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| show | 2-3:1
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| show | CD 3+ and CD 4+
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| show | CD 3+ and CD 8+
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| Immunophenotype of B cells | show 🗑
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| show | CD 34+
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| Immunophenotype of natural killer cells | show 🗑
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| Immunophenotype profiles of CLL | show 🗑
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| Immunophenotype profiles of MCL | show 🗑
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| show | kappa or lambda Surface Ig, CD19, CD20, FMC-7, CD103, and CD11c
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| Immunophenotypic profile of SLVL (Splenic lymphoma with villous lymphocytes) MBL (Monocytoid B cell lymphoma) MZL (Marginal zone lymphoma) | show 🗑
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| show | kappa or lambda surface IgG, CD19, CD20, and CD10
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| show | kappa or lambda surface IgG, CD19 and CD20
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| Immunophenotypic profile of LGL-NK (Large granular lymphocyte syndrome NK cell) | show 🗑
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| Immunophenotypic profile of LGL-T (Large granular lymphocyte syndrome T cell) | show 🗑
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| show | kappa or lambda surface IgG, CD19, CD20, and FMC-7
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| Immunophenotypic profile of PLL-T ((prolymphocytic leukemia T cell) | show 🗑
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| Immunophenotypic profile of Mycosis fungoides-Sezary's cell | show 🗑
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| What are the prognostic factors of CLL? | show 🗑
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| show | Chronic lymphocyte leukemia (CLL)
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| show | 65 years
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| show | Skin, lungs, and GI tract
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| show | Hemolytic anemia, thrombocytopenia, neutropenia, and pure red cell aplasia
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| What organisms are the most frequent causes of recurrent infections in CLL? | show 🗑
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| What are the possible disease transformations of CLL? | show 🗑
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| (T or F) Fever should not be attributed to CLL and should be considered a manifestation of infection or drug-induced. | show 🗑
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| What is the historical diagnostic lymphocyte count criteria for CLL? | show 🗑
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| What is the Rai Stage 0 criteria for clinical staging of CLL? | show 🗑
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| show | Lymphocytosis plus enlarged nodes
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| show | Lymphocytosis plus enlarged spleen and/or liver (nodes may not be enlarged)
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| What is the Rai Stage III criteria for clinical staging of CLL? | show 🗑
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| show | Lymphocytosis plus thrombocytopenia (plt<100,000/mm3). Enlargement of nodes, spleen, and liver; anemia may or may not be present.
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| What is the most frequent cytogenetic abnormality associated with CLL? | show 🗑
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| show | 17q deletion
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| show | True.
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| What is the relationship between the degree of somatic hypermutation of the immunoglobulin heavy-chain variable region with ZAP-70 expression? | show 🗑
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| (T or F) Low expression of CD38 (<30%) confers a better prognosis in CLL? | show 🗑
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| show | False. The higher the expression of Bcl-2, the worse the prognosis. The presence of Bcl-6 mutation indicates a better prognosis in CLL
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| What is the treatment for hypogammaglobulinemia with recurrent infection in the setting of CLL? | show 🗑
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| show | Prednisone
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| What purine nucleosides are used for treatment of CLL? | show 🗑
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| show | Splenic lymphoma with Villous Lymphocytes
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| A syndrome characterized by rheumatoid arthritis, splenomegaly, and neutropenia. | show 🗑
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| show | No treatment is necessary in most cases. Prompt treatment of infections is important. Those with frequent infections may require growth factor suppor twith G-CSF. More aggressive forms may require combination chemotherapy, but with poor response.
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