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Clinical Aspect of Coagulation and Hemostasis II

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
show Approximately 50%  
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show Extremities are blue, cold, and pulseless.  
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show Aterial thromi  
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show True.  
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show 1)Lupus anticoagulant 2)Prothrombin antibodies 3)Anti-cardiolipin antibodies 4)B2 Glycoprotein 1 antibodies  
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show 1)Vascular thrombosis (artieral or venous) 2)Pregnancy complicatons  
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show 1)Anti-cardiolipin Antibody (IgG or IgM) 2) Positive Lupus anticoagulant assay  
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What is the suggested evaluation for venous thromboembolism in a patient with no previous family or personal history?   show
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show 1)Lupus anticoagulant and anticardiolipin Ab 2)Homocysteine level 3)Lipid levels 4)Rule out estrogen and vasculitic risk factors  
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What are the accepted indications for thromboytic therapy?   show
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What are the contraindications to thrombolytic therapy?   show
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show Reversible Direct Thrombin (FIIa) Inhibitor  
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show Reversible Direct Thrombin(IIa) Inhibitors  
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show Irreversible Direct Thrombin (IIa) Inhibitors  
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show 1)Heparin 2)Low Molecular Weight Heparin 3)Fondaparinux  
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Why does aPTT need to be standarized before comparing from different clinical laboratories?   show
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Factor Xa to Factor IIa activity of unfractionated heparin vs. low molecular weight heparin   show
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show 1)Better predictability of anticoagulant effect at a given dose;therefore, less need for lab monitoring 2)Longer plasma half-life 3)Less effect on the hemostatic properties of the endothelium and platelets perhaps accounting for less hemorrhagic potential  
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(T or F) LMWH never need monitoring.   show
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(T or F) LMWH is fully reversible with protamine.   show
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What is the half-life of heparin?   show
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show 4-6 hours  
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What is the half-life of Fondaparinux (Arixtra)?   show
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show Protamine  
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show No  
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How is LMWH excreted?   show
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How is fondaparinux excreted?   show
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show Anti-Xa assay  
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How are the anticoagulant effects monitored by fondaparinux (Arixtra)?   show
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How is heparin administered?   show
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How is LMWH administered?   show
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show SQ  
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show 39-51 mins  
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show 1.5 hours  
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show 25 mins  
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show No  
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Are the anticoagulant effects of Lepirudin reversible?   show
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show No  
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show Metabolized by the liver  
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How is Lepirudin excreted?   show
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show Renally  
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show IV  
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show IV  
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show IV  
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show 36-42 hours  
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What are the complications of warfarin therapy?   show
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