Platelet Disorders
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| show | 7-10 days
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| What is contained in alpha granules of platelets? | show 🗑
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| What is contained in dense granules of platelets? | show 🗑
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| show | Wiskott-Aldrich Syndrome (ACS)
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| A autosomal dominant congential thrombocytopenia syndrome characterized by large/pale platelets which lack alpha granules. | show 🗑
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| show | MYH9-related (May-Hegglin, Sebastian, Fechtner, Epstein)
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| What is pseudothrombocytopenia? | show 🗑
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| What is the criteria for diagnosis of Immune Thrombocytopenic Purpura (ITP)? | show 🗑
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| Age of onset of Acute vs. Chronic Immune Thrombocytopenia Purpura | show 🗑
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| show | Acute ITP: 1:1 (M:F) and Chronic ITP 1:3 (M:F)
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| Typical platelet count in Acute vs. Chronic Immune Thrombocytopenic Purpura (ITP) | show 🗑
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| show | True.
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| show | False. Chronic ITP does not resolve without treatment.
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| show | CLL
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| show | SLE
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| What infections are commonly associated with ITP? | show 🗑
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| show | Steroids, IVIg, anti-D
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| show | If asymptomatic, treat with prednisone. If symptomatic, treat with steroids, IVIg, and anti-D
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| What is the treatment for asymtomatic ITP with platelet counts 30-100,000? | show 🗑
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| What is the treatment for ITP with platelet counts 30-100,000 and minor bleeding? | show 🗑
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| What is the treatment for ITP with platelet counts 30-100,000 and major bleeding? | show 🗑
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| show | Cyclophosphamide, Vinca alkaloids, Danazol, Vit C, Protein A immunoadsorption/Plasma exchange, Interferon alpha, Azathioprine, Amicar
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| show | True. Relapse typically occurs in first 6 months.
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| Describe the immune complex deposition of drug-induced thrombocytopenia | show 🗑
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| What are common drugs that incite immune complex deposition drug-induced thrombocytopenia? | show 🗑
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| Describe the Hapten type drug-induced thrombocytopenia | show 🗑
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| Pathogenesis of Heparin-Induced Thrombocytopenia Type II | show 🗑
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| show | Discontinue heparin therapy
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| show | 1)5-10 days after heparin start 2)Within 24 hours if recent exposure to heparin (<3 months)
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| What is the typical change in platelet count in HITT? | show 🗑
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| What are the clinical manifestations of Thrombotic Thrombocytopenic Purpura? | show 🗑
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| Pathogenesis of TTP | show 🗑
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| show | Plasma exchange
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| show | Preeclampsia
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| An obstetric complication characterized by elevated liver enzymes, low platelets, and hemolytic anemia. | show 🗑
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| show | Hemolytic Uremic Syndrome
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| What is the inheritance pattern of Bernard Soulier Disease? | show 🗑
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| show | It is a disorder of platelet adhesion due to the absence of gycoprotein Ib receptor on the platelet
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| show | An intrinsic platelet defect associated with defect in Glanzmann IIbIIIa receptors on platelets resulting in defect in platelet aggregation.
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| (T or F) Each unit of platelet concentrate is from an individual donor. | show 🗑
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| show | 5 days
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| Definition of Thrombocytosis | show 🗑
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