Cardiopulmonary Physiology - Unit 4 - SPC
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| show | Normal = (4/5) = 0.8, ABG values are norm, 7.40, CO2 = 40, O2 = 100
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| show | High = (5/5) = 1.0, ABG pH = 7.45, CO2 = 30, O2 = 110(hypocapnic) because venous blood not in the mix so CO2 is not in ABG as much
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| Low V/Q ratio = Shunt = Refractory Hypoxemia | show 🗑
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| Deadspace disorders | show 🗑
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| Shunt disorders | show 🗑
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| show | Diffusion over alveolar Cap. Membrane, directoly proportional to SA, Pressure Gradient, and Diffusion coefficent, inversly proportional to thickness
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| Normal DLCO | show 🗑
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| show | Recumbent position - Increases SA, exercise - increases ventilation, perfusion, and hemoglobin, Body size = height not wt.
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| How to decrease diffusion factors | show 🗑
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| How is Oxygen transported in the blood | show 🗑
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| show | made p of 2 alpha and 2 beta polypeptide chains, with 4 HEME groups
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| show | point of reference for loading or unloading of O2 onto hemoglobin, partial pressure required to saturate the Hb to 50% level
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| Normal p50 | show 🗑
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| show | less than 27 = left shift(LOAD), increased affinity between O2 and Hb, O2 loading easier in LUNGS, but harder in Tissues
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| Increased p50 | show 🗑
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| show | increased pH(ALKALEMIA), decreased CO2, Hypothermia, Decreased 2,3,DPG, promotes O@ loading
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| RIGHT Shift Factors | show 🗑
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| BOHR effect | show 🗑
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| Methemoglobin (MHb)- Bad hemoglobin | show 🗑
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| Carboxyhemoglobin (HbCO) | show 🗑
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| show | in the fetus and neosaltered 2,3,DPG binding causes DECREASED p50, O2 load on Hb but not unload in tissues
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| show | DO2 = C.O. x (CaO2x10), normal is 5 x (20x10)= 1000ml/min, if given dl, multiply by 10
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| O2 consumption/uptake | show 🗑
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| show | Exercise, Fever, Seizures, Shivering, all >250ml.min
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| Factors that decrease O2 consumption | show 🗑
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| C(a-v)O2 - (a-v) is diff between arterial and venous | show 🗑
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| show | Decreased CO, Increased O2 consumption, exercise, shivering, seizure, fever, tissues asking for more O2
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| Factors that decrease (a-v) gap | show 🗑
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| show | O2ER = (CaO2-CvO2)/CaO2, normal = 25%, (20-15)/20
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| Increased ER | show 🗑
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| Decreased ER | show 🗑
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| SVO2 = Venous saturation | show 🗑
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| show | Ex. 80%, incresaed CO, decreased O2 consumption at tissues, Peripheral shunting, Cyanide poisoning, hypothermia
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| show | Ex. 60%, decreased CO, increased O2 consumption at tissues, exercise, seizures, shivering, fever
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| show | QS/QT= (CCO2-CaO2)/(CCO2-CvO2)
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| show | <10=NORMAL, 10-20%=MILD, 20-30%=MODERATE, >30%=SEVERE
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| CO2 Transport | show 🗑
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| Haldane Effect | show 🗑
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| show | Chloride IN, Bicarb OUT, CO2 LOADED, O2 UNLOADED(H+ increase)
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