dynamics & kinetics
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| pharmacodynamics | show 🗑
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| more pharmacodynamics | show 🗑
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| show | ligand gated ion channels; g-protein coupled receptors; enzyme linked; intracellular
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| show | change in concentration of some types of ions; ex: cholinergic nicotinic receptors
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| show | spans membranes 7X, binds GDP or GTP-large protein family; ex: alpha and beta adrenoreceptors; protein phosphorylation
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| show | ex: insulin receptors; protein and receptor phosphorylation
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| Intracellular receptors | show 🗑
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| Effectors | show 🗑
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| Second messengers | show 🗑
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| show | stimulates adenylyl cyclase & Ca channels
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| Gp proteins | show 🗑
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| show | inhibitory; inactivates adenylyl cyclase
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| Drug-receptor binding | show 🗑
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| show | measures drug response against increasing concentrations of drug; efficacy (E max), potency (EC50), median effective dose (ED 50), and median lethal dose (LD 50)
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| show | the study of pharmacodynamics is based on the concept of drug-receptor binding
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| Potency | show 🗑
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| Efficacy | show 🗑
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| show | favor inactive formation when bound; competitive-irreversibly bound, affects POTENCY, not efficacy; noncompetitive-binds to an allosteric site-reduces EFFICACY, not potency
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| show | demonstrates average effect of a drug as a function of its concentration in a population of individuals; ED50, TD50, LD50
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| show | safety of the drug; = TD50/ED50; the narrower the distance between 2 curves, the smaller the therapeutic window
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| show | concentration of drug, metabolic rate, frequency of dosing, food-drug interactions, drug-drug interactions, absorption rate, genetics, excretion rate, half-life of drug, changing medical conditions
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Created by:
rlvander
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