Organisation of the Body
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| show | Do not harm when all is normal - do not obstruct
Automatically seal vascular punctures
Prevent loss of blood
Recruit healing helpers
Resolve when healed
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| Stages of hemostasis | show 🗑
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| show | Damaged endothelium initiates sympathetic reflex (noradrenaline and neuropeptides) releases endothelin-1, a vasoconstrictor
Arteriolar smooth muscle contraction restricts flow
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| show | Small cytoplasmic fragments of megakaryocytes
Life span of 8-10 days
Abundant in blood
Packed with granules
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| Platelet aggregation reaction | show 🗑
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| Platelet granule functions | show 🗑
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| Thrombopoiesis | show 🗑
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| Platelet disorders | show 🗑
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| show | Signal amplification by a series of protease reactions
Initiated by exposed charged surface and release of tissue factor and phospholipid from endothelium
Generates insoluble fibrin mesh
Regulated
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| show | Present in plasma at high concentrations
High molecular weight
Made in the liver
6 polypeptides - 2 alpha, 2 beta and 2 gamma
Fibrinopeptides cleaved by thrombin to allow aggregation
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| show | Thrombin cleaves fibrinopeptides in fibrinogen
Exposed regions spontaneously aggregate
Meshwork traps platelets, rbc etc to stabilise plug
Further crosslinking GLN-LYS by factor XIIIa to form gamma dimers
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| Vitamin K dependent zymogens | show 🗑
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| Vitamin K deficiency | show 🗑
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| The common pathway | show 🗑
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| Inhibitors of clotting | show 🗑
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| show | A serine protease inhibitor encoded in the human genome
Also alpha 1 anti trypsin, Complement C1q inhibitor, PLA-1
ATIII-thrombin interaction enhanced 1000 fold by hepSO4 GAG and heparin
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| Haemophilia | show 🗑
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| Fibrinolysis | show 🗑
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