Physiology and Pharmacology
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| Ficks law | show 🗑
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| show | Blood comes into equilibrium with alveolar gas
Doubling diffusion capacity wont alter amount of gas exchanged
Doubling blood flow will double amount of gas exchanges
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| show | Partial pressure gradient remains essentially constant along capillary
Doubling blood flow wont change the amount of gas exchanged
Doubling diffusion capacity will double exchange
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| What determines perfusion or diffusion limitation | show 🗑
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| Inert gases | show 🗑
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| show | Solubility on blood is greater than in membrane as they react with blood
They equilibrate slowly
At rest they equilibrate over 1/3 of a capillary in 0.25 secs
This is slowed in pulmonary fibrosis with thickened membrane
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| show | Solubility in membrane greater than in blood
Diffusion limited
Can be used to measure diffusing capacity of lung as this affects rate of exchange
Measure gas uptake, conc in alveoli and venous blood
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| show | Can only use b to include chemical reaction with blood is speed is fast
1/Dl = 1/Dm + 1/sigmaVc
Sigma = diffusing capacity in blood
Rate of reaction of O2 with free Hb is faster than RBCs, so limit is diffusion not reaction
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