Toxidromes Word Scramble
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| Question | Answer |
| Define toxidrome | A toxic syndrome made up of a constellation of signs and symptoms that consistently result from a particular toxin. |
| What are common toxidromes? | Cholinergic Anticholinergic Narcotic/Opioid Sedative/Hypnotic Sympathomimetics Hallucinogenics |
| What characterises cholinergic toxidromes? | Elevated levels of acetycholine. |
| What are examples of cholinergics? | Nicotine and mushrooms. |
| What are examples of anticholinesterases? | Organophosphates Carbamate insecticides Nerve gas (sarin) Urethanes |
| What is the mnemonic for remembering cholinergic toxidromes's symptoms? | DUMBELS |
| What does the mnemonic DUMBELS stand for? | D-iaphoresis. U-rination. M-iosis. B-ronchorrhea, broncheospasm,bradycardia. E-mesis, excitation of skeleteal muscle. L-acrimation. S-alivation,seizures. |
| What is the management of cholinergic toxidromes? | Atropine and supportive ABC's. |
| What is the definition of an anticholinergic drug? | A drug that generally interferes with the binding of acetycholine to muscarinic receptors. |
| What does the administration of anicholinergic drugs result in? | The inhibition or blockage of the parasympathetic nervous system. |
| What are examples of anticholinergic drugs? | Atropine Anithistamines Antipsychotics Antiparkinsons TCA's - Tricyclic antidepressants |
| What are the symptoms of the anticholinergic toxidrome? | Altered LOC - agitation, hallucinations. Mydriasis and blurred vision Hot,dry,flushed skin- hyperthermia Dry mucus membranes Tachycardia, palpations, arrythmias Urinary retention, decreased bowel sounds |
| What is the management of the anticholinergic toxidrome? | Support ABC Monitor ECG IV |
| Define sympomemetic toxidrome. | A toxidrome that mimics the sympathetic nervous system effects. |
| What toxidrome is produced when a pt is withdrawing from alcohol or drugs? | Sympathomimetic toxidrome. |
| Whithdrawal from what drugs may produce a sympathomimetic woxidrome? | Caffine Cocaine Amphetamine LSD Ecstacy Theophylline |
| What is an easy way of telling between anticholinergic and sympathomimetic toxidromes? | Anticholinergic - flushed, dry skin, no sweating. Sympathomimetic - pale skin, diaphoresis. |
| What is the mnemonic for remembering the symptoms of sympathomimetic toxidromes? | THIRDS. |
| What does the mnemonic THIRDS stand for? | T-achycardia H-yperthermia I-ncreased motor activity R-estlessness D-ilated pupils S-weating |
| What is the management for sympathomimentic toxidromes? | Supportive ABCs Cooling as required Monitor ECG IV Consider 0.9 NaCl infusion. |
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boermedic
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