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development of back
Question | Answer |
---|---|
where is neural tube and neural crest cell develope from? | Epiblast-> ectoderm -> neura tube and neural crest cell |
Neuroepithelial layer | give rise to all spinal neurons and some support cell |
Mantle layer | form by neuroepithelial cell that divide and differentiate into neuroblast cells |
Marginal layer | region that will contain white matter + Meninges |
Meninges | layer of membrane that give rise to CNS |
after thickening of neural tube, what does mantle layer differentiate into? | 1) Alar plate (posterior horn) 2) Basal plate (anterior horn) |
Alar plate | formed from mantle layer, it formed posterior horn (sensory neuron) |
Basal plate | formed from mantle layer, it formed anterior horn (motor neuron) |
Intermediate horm | formed between posterior and anterior horns |
where does motor and sensory neuron meet? | spinal nerve |
where does Posterior ramus innverate? | Motor and sensory of dermomyotome of Back example: erretus and intrinsic muscle of back |
Where does anteriro ramus innverate with? | Motor and sensory of dermomyotome of body wall and limbs |
Ramus vs Root | Root contribute to ramus Root contain either sensory (posterior root) or motor (anterior root) neurons Ramus contains both motor and sensory |
landmark of dermatome | C3=neck, T4=nipple, T10=umbilical, L1-Inguinal line, C8=5th digit of hand, C6=Pollex, L4=knee, L5=anterior ankle and foot, S2=posterior lower limb |
where does anterior ramus goes to? | To the hypomere: skin (everywhere except midline of back) and to hypaxial (extrinsic0 muscle |
Where does posterior ramus goes to? | To the epimere: skin along the midline of back (to the coastal angle) and to epaxial (instrinsic) muscle |
Hypomere | skin (everywhere except midline of back) and to the hypaxial (extrinsic muscle) inneverated by anterior ramus |
Epimere | Skin along the midline of back (to the coastal angle) and to epaxial(intrinsic) muscle innverated by posterior ramus |
Sclerotome resegmentation | Sclerotome is resegnmented into upper and lower part, which then migrate to adjacent to allow nerve fiber transmission proces |
what does sclerotomal mesenchyme give rise to? | Vertebrae and Rib Sclerotomal mesenchyme ==> cartilage ==> bone |
disease when spinous process is not form? | Spina bifida |
Name possible clinical disease associate with spina bifida | 1) spina bifida occulta 2) meningocele (surgically removed) 3) meningomyelocele 4) Rachischisis (usually fatal) |
After formation of vertebrate, what does notochord become? | Nucleus pulposus |
Which segment does T12 most assoicate with? | Lower lumbar spinal cord segment |
Which segment does L1 most assoicate with? | All sacral spinal cord segment |