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Path 8 Parasites
Path
Question | Answer |
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Leading cause of death (cerebral) under 5 y/o in sub-Saharan Africa. Transmitted by female Anopheles mosquito. Infectious stage is sporozoite. Causes RBCs to clump together and stick to endothel lining small blood vessels->ischemia downstream. Splenomega | Malaria (Plasmodium) |
Transmitted by deer ticks w white footed mouse as reservoir. Attack RBCs->fever and hemolytic anemia. Blood smear shows Maltese cross tetrads. | Babesiosis (B. microti) |
Chronic inflamm of skin, mucous membs, or viscera d/t obligate intracell, kinetoplastid protozoan parasites transmitted by sandflies. Endemic in Middle East, S. Asia, Africa, Latin America. | Leishmaniasis - Visceral: L. donovani, L. chagasi. - Cutaneous (granulomatous): L. major, L. mexicana, L. braziliensis - Mucocutaneous: L. braziliensis |
Kinetoplastid parasites that proliferate as extracell forms in blood->sustained or intermittent (WAVES OF) fevers, lymphadenopathy, splenomegaly, SLEEPING SICKNESS, chachexia, death. Tsetse flies are reservoir, red rubbery chancre at bite. Mott cells | African Trypanosomiasis - T. b. rhodesiense = East Africa, acute, virulent - T. b. gambiense = West Africa, chronic |
Transmitted by Reduvid "kissing" bugs. Amastigote activation by acidic phagolysosome-> lyse cells-> penetrate smooth, skeletal, and heart muscle. Dilated cardiomyopathy | Chagas (Trypanosoma cruzi) |
Worms live in soil, penetrate skin, travel in circulation to lungs, travel up trachea to be swallowed. Cause diarrhea, bloating in immunocompromised and can AUTOINFECT. | Strongyloidiasis |
Parasite w head (scolex) that has suckers and hooklets that attach to intestinal wall and segments called proglottids (distal ones have eggs and detach into feces). Can cause cysts in brain tissue. | Tapeworms - Taenia solium from pork - T. saginata from beef - Diphyllobothrium latum from fish Hydatid disease from ingesting Echinococcus granulosus eggs. can cause liver cysts. |
Ingested by eating undercooked pigs, boars, horses. cause fever, myalgia, marked eosinophilia, and periorbital edema. Coiled larvae that encyst in striated skeletal muscle w rich blood supply (diaphragm, extraocular, laryngeal, deltoid muscles). | Trichinosis (Trichinella spiralis) |
Transmitted by fresh water snails. cause white granulomas throughout gut and liver and pipe-stem fibrosis->hepatic cirrhosis. can also line wall of bladder->calcified bladder and association w squamous cell CA of bladder | Schistosomiasis |
Nematode transmitted by mosquitoes. Asymptomatic microfilaremia, Recurrent lymphadenitis, Elephantiasis, Tropical pulm eosinophilia. Symbiotic relationship w Wolbachia bacteria | Lymphatic Filariasis (Wuchereria bancrofti) |
Nematode transmitted by black flies. Causes "River blindness" and leopard/lizard/elephant skin, and Progressive eye lesions beginning w punctate keratitis w fluffy opacities of the cornea->sclerosing keratitis. | Onchocerciasis (Onchocerca volvulus) |