Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Antifungal Pharm

QuestionAnswer
most important antifungal drug for severe infections ? * Amp-B
Are the mainstays of standard treatment ? * -Azoles (itra and flu)
Amphotericin B spectrum ? * treats just about everything.... DOC for most severe fungal infections
When to use ? * Systemic use reserved for severe, life-threatening infections
MOA of Amp-B ? * preferentially binds to ergosterol in fungal membranes to punch holes in it
Amp B Lipid Formulations ? * less toxicity and nephrotoxicity, but expensive
Amp-B SE's ? * Nephrotoxicity (constricts afferent arterioles)so monitor kidneys, Hypokalemia , cytokine storm - n/v/f,
Flucytosine Spectrum ? * Narrow spectrum antimycotic - Cryptococcals
Flucytosine use ? * Systemic candidiasis & cryptococcal infections ---Cryptococcal meningitis .... * never used alone, usu w/Amp-B
Flucytosine MOA ? * blocks dUMP/nucleic acid synthesis to make RNA/DNA
Flucytosine Side Effects ? * Bone Marrow Depression, n/v/d, GI mucositis - sores in mouth
Antifungal azoles advantages ? * treatment of systemic fungal infections bc low toxicity
Azole disadvantages ? * Inhibit P450 drug-metabolizing enzymes and can increase the levels of many other drugs
Azole MOA ? * Inhibits fungal cytochrome P450-dependent lanosterol 14-alpha-demethylase, which decreases ergosterol, which disrupts fungal cell membrane
Fluconazole usu uses ? * Coccidioidomycosis, meningitis, cryptococcosis, candidiasis.... * Not aspergillosis
Fluconazole bioavailability and drug/drug interactions ? * Absorption not affected by food or gastric pH.... * Fewer drug interactions than itraconazole.... * Eliminated by kidneys so can be used for UTIs
Itraconazole activity ? * Invasive aspergillosis , Blastomycosis, Cryptococcosis, Histoplasmosis , Suspected fungal infection w/ neutropenic fever , Coccidioidomycosis , Sporotrichosis
Itraconazole bioavailability ? * Requires food and acidic gastric pH for drug solubilization, acid lowering drugs can lower this drugs effectiveness
Itraconazole Oral Solution? * doesnt need an acidic environment.... but causes GI upset....excreted via hepatic system
Itraconazole Side Effects ? * drug/drug interactions, CYP3A4 inhibitor.... * has Negative Ionotropic Effects - Can cause hypertension, hypokalemia, and peripheral edema
Voriconazole use ? * invasive aspergillosis (DOC)
Voriconazole basics ? * not affected by pH or food.... * hepatically eliminated
Voriconazole Side Effects ? * Inhibits CYP3A4, Visual Changes, Neurotoxic, photosensitive rash, arrhytmias/QT prolongation
Caspofungin MOA ? * Impairs cell wall production inhibits beta-(1,3)-D-glucan synthesis (cell wall component) weaken cell wall
Active against ? * Active against Candida and aspergillus
When to use ? * salvage therapy when Amp B or voriconazole has failed (or drug intolerance)
Created by: thamrick800
Popular Medical sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards