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TORCH Infections
Question | Answer |
---|---|
TORCH Infection basics ? | * Vertically transmission from mother to fetus/baby...* Can cause spontaneous abortions or rash/occular issues |
TORCH stands for ? | * T=toxoplasmosis -- O=other (syphilis) -- R=rubella -- C=cytomegalovirus (CMV) -- H=herpes simplex (HSV) ...........* others are Varicella-zoster virus, Parvo,Borrelia(Lyme Disease), Group B strep, Listeria, (HIV) |
When do you think of TORCH infections? | * Intrauterine growth restriction (IUGR) infants -- Hepatosplenomegaly -- Thrombocytopenia -- Unusual rash -- Concerning maternal history -- “Classic” findings of any specific infection |
TORCH incidence ? | * very rare ..... * CMV is the most common in 1/100 births |
Diagnosing TORCH Infection ? | * NO Titer workup... * based on Hx and CxSx and directed studies only |
Toxoplasmosis basics ? | * from a parasite from a CAT... * ingesting cysts in animal tissues or from oocytes from cat feces.... * High in Greece from meat eating... * Ppl usu asymptamatic....* Fatal if get in 1st trimester |
Toxo. CxSx ? | * see eye issues, hydroceph, and intrcranial calcifications.... * Chorioretinitis is the most common issue seen in infants that were born asymptomatic |
Toxo. Screening ? | * Newborn serologies with IgM |
Syphilis basics ? | * worry about 1 --> 2 syphilis in mothers.... *RPR and VDLR screening and then FTA is those are + ..... * TmT = Benzathine penicillin G |
Rubella basics ? | * single starnded RNA virus .... * part of the measles/mumps shot.... Eliminated from USA |
CMV basics ? | * Most common congenital viral infection .... * is a DNA HerpesVirus.... * most at danger to transmit when primary infection while pregnant..... * |
CMV CxSx = ? | * 90% are asymptomatic at birth...... * See Hearing Loss, vision, cranial calcifications, and growth loss |
CMV Labs/TMT = ? | * Viral isolation from urine or saliva in 1st 3 weeks of life .... * Tmt only in Symptomatic infants bc of SEs = Ganciclovir |
Herpes Simplex (HSV) | * double stranded DNA...* RARE !.... * Primary infection is more harmful than reactivation.... *Get from mothers Vag Canal, why we do C-Section in them |
HSV CxSx ? | * most asymptomatic, and even then are very non-specific... * eyes, skin rash, and CNS issues |
HSV Dx and TmT = ? | * Dx: Culture Maternal and Infant Lesions directly .... * TmT: High dose acyclovir |