Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
HIV drugs
| Question | Answer |
|---|---|
| CCR5 antagonist (MOA), | Maraviroc, CCR5 antagonist prevent the co-receptor to bind with HIV to help facilitate the fusion of HIV RNA. |
| Maraviroc (Rights) ADR | CCR5 antagonist, Rash, SJS, GI, Hepatotoxicity, URTI, Drug interactions as CYP 3a4 inhibitor |
| Fusion inhibitor (enfuvirtide) | SC BID (painful), |
| enfuvirtide ADR | injection site painful rxn 98%, hypersensitivity rxn, increase in bacterial pneumoniae, nodule formation at the injection site |
| NRTI meds (know class ADR: Lactic acidosis, hepatic steatosis & lipodystrophY) | ZELTA (Zidovudine, Tenofovir, Abacavir, Lamivudine, Emtricitabine) |
| NRTI MOA | prevent conversion of RNA to DNA (reverse transcriptase) |
| Abacavir ADR | NRTI: life threatening hypersensitivity (FARMS N/V) |
| Tenofovir ADR | GI intolerance, renal impairment |
| Zidovudine ADR | HA, bone marrow suppresion |
| Lamivudine and Emtricitabine | minimal toxicity |
| Integrase inhibitor (MOA) | it will prevent the integration of viral DNA into cellular DNA. raltegravir, elvitegravir, stribild |
| Integrase inhibitor ADR of Raltegravir | CHIMP N/D (CPK elevation, Nausea, diarrhea, pyrexia, headache, myocardial infraction) |
| Integrase inhibitor Stribild, Elvitegravir (cobicistat) | one tablet a day with food, don't use if CrCl < 70 or with other ART, Cobcistat is booster. |
| Stribild | N/D, renal impairment, decrease bone mineral density |
| Prevention: what can you do? Sexual | Practice CDC's ABC. Latex condom and water-based lubricant. Early ART, do TRUVADA for prophylaxis. Male circumcision Dental dams |
| Prevention: what can you do? parenteral | testing/treatment for accidental needlestick. universal precautions. screening of donated blood/organs etc. clean needle programs. |
| Perinatal: what can you do? perinatal | treat during pregnancy (don't use efavirenz). RNA count less than 1000. Elective C-section. avoid breastfeeding if safe alternative exists. |
| Efavirenz Strength | NNRTI. well tolerated, low pill burden, PI option reserved for future use |
| Efavirenz Weakness | CNS symptoms, possible teratogenicty,DI, rash, hepatotoxicity, resistance single mutation |
| PCP prophylaxis Primary | Bactrim 1 ds, if sulfa allergy then dapsone. Start if CD4 < 200, stop if CD4 > 200 for > 3 months. |
| PCP prophylaxis secondary | same as primary, only this time don't stop treatment if CD4 >200 |
| Toxoplasma gondii | start bactrim ds qd if CD4 < 100 stop when CD4 > 200 for 3 months |
| MAC (mycobaterium avium complex) | start azithromycin 1200 mg po qwk if CD4 < 50 Stop when CD4 > 100 for 3 months |
| DI ART | CASHEW-G (contraceptive, antimicrobial (rifampin), antifungal, anticonvulsant, statins, herbals, ED, Gastric acid suppressant) |
| Four vaccine u need to avoid | Varicella, Zostavax, MMR, live attenuated influenza vaccine |
| Four vaccine u need to get | Pneumovax (at any CD4 above 200), inactive influenza (annually), Hep b (anti-HBc negative), Hep A (at risk plus negative anti-HAV) |
Created by:
Illusion
Popular Medical sets