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Renal - Awesome
Urine studies, casts and other renal
Question | Answer |
---|---|
muddy brown casts | acute tubular necrosis (necrotic so muddy and brown) |
RBC casts | glomerular damage |
Urine Cl- < 10 mmol/l - what does this mean? | Often associated with volume depletion (increased proximal tubular reabsorption of HCO3) Respond to saline infusion (replaces chloride and volume) Common causes: previous thiazide diuretic therapy, vomiting (90% of cases) |
Urine Cl- > 20 mmol/l - what does this mean? | |
What should you be thinking when pts have high Cr and pelvic tumors or irradiation, congenital urinary abnormalities, kidney stones, genitourinary infections, procedures or surgeries, and prostatic enlargement - should increase suspicion for obstruction | obstruction as cause of AKI - do kidney US |
When should you NOT use FeNa | with diuretic use or obstructive etiology |
diffuse proliferative lupus nephritis - how to dx and how to treat | Dx with kidney bx, tx with prednisone and IV cyclophosphamide for 6 months, followed by azathioprine or mycophenolate mofetil maintenance therapy, monitor with titers of anti-ds-DNA |
when do you think of low phos? | chronic alcohol use, critical illness, and malnutrition |
fractional excretion of phosphate (FEPO4) less than 5% | less than 5% suggests increased cellular uptake or extrarenal phosphate loss as the cause of the low serum phosphate |
fractional excretion of phosphate value greater than 5% | is consistent with renal phosphate wasting |
in malnutrition, what should the fractional excretion of phosphate be? | less than 5% - extrarenal |
what do you see in primary HyperPTH | high PTH, low phos, high Ca; no other proximal renal tubular abnormalities |
true or false - hyperaldo is always associated with hypo K | FALSE - Primary hyperaldosteronism is inconsistently associated with hypokalemia, and its absence in a patient with resistant hypertension should not influence the decision to screen for this condition |
normal urine protein in 24h | More than 95% of adults will excrete less than 130 mg/24 h of protein in the urine, and the normal value is defined as less than 150 mg/24 h |
urine dipstick positivity for blood in the absence of hematuria | rhabdo |
Propylene glycol causes what kind of acid base abnormality | in preparations of intravenous benzodiazepines (such as lorazepam and diazepam) - a lactic acidosis with an increased anion gap may occur |
nephrotic syndrome - what is the amount of protein that defines it? what are the other symptoms of the syndrome? | urine protein–creatinine ratio greater than 3.5 mg/mg, hypoalbuminemia, hyperlipidemia, lipiduria, edema, and hypercoagulability |
new-onset hypertension accompanied by the development of proteinuria | Preeclampsia |
tx idiopathic hypercalciuria with what | thiazide diuretic (HCTZ or cholorthalidone) which reabsorbs Ca |
give what to alkalinize the urine | K citrate |