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Oncology – Awesome
Random oncology associations
| Question | Answer |
|---|---|
| cancer that is associated with increased risk of cancer of the ampulla of Vater | Familial adenomatous polyposis |
| highest risk of colon cancer | FAP |
| colon cancers usually arise from what type of polyps | adenomas |
| what chromosomal abnormality is associated with FAP | mutation of the APC gene on the chromosome 5q |
| osteoma of the mandible, skull, long bones | Gardner Syndrome - a subtype of FAP |
| family history requirements of HNPCC (hereditary non polyposis colon cancer) | 3 relatives (one must be a first degree of one of the others), 2 generations, 1 < 50 yo |
| How to treat acute myelocytic leukemia (AML) | ATRA (all trans retinoic acid)+ arsenic trioxide |
| What is the side effect of ATRA (all trans retinoic acid) and how to treat it? | diferentiatiation syndrome - "cytokine storm," and all of the pathophysiologic consequences result from the release of inflammatory cytokines, rapid weight gain; treat with dexamthasone |
| pt with BRAC1 or 2. What screening do we do? | pelvic US for ovarian CA x1 and annual mammo's plus MRI for BRAC1 or 2 carriers |
| Treatment of ampullary cancer, what is ti associated with? | pancreaticoduodenectomy, ampulla of vater cancer associated with FAP & Peutz Jehger, need EGD surveillance |
| cervical cancer who have high-risk features identified at surgery (large primary tumor, deep stromal invasion, lymphovascular invasion, or positive lymph nodes) should receive | adjuvant treatment with a combination of chemotherapy and radiation |
| Pt with h/o cervical CA after completed therapy | Patients who have completed therapy should have a pelvic examination and Pap smear every 3 to 6 months for 2 years, then every 6 months for the next 3 years, and then annually |
| Pt with advanced cervical CA | periodic chest radiographs, CT scans of the abdomen and pelvis, or both. However, the best treatment recommendation after surgical resection is to maximize the chance of cure with chemotherapy and radiation treatment |
| What should you do for a patient who has malignant melanoma, 1 mm to 4 mm thickness? | Do sentinel lymph node biopsy |
| What is the most important prognostic factor in patients with early stage melanoma? | Regional lymph node involvement |
| If the patient has melanoma less than 1 mm thick, what should you further look out for? | Do sentinel lymph node biopsy if any of these high-risk features are present: ulceration, > 1 mitosis/ mm2, lymph over vascular invasion |
| What to do for the patient with malignant melanoma if positive sentinel lymph node is found? | Complete lymphadenectomy, and activate interferon alpha |
| In malignant melanoma, who should get activated interferon alpha? | Positive lymph node or melanoma 4 mm or more thick |
Created by:
christinapham
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