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protozoa
Single celled organism
Disease | Organism | Transmission | Diagnosis | Treatment | Morphology |
---|---|---|---|---|---|
Spiking fevers, hepatosplenomegaly, pancytopenia (increased abdominal size, replicates in phagocytes). | Visceral leishmaniasis (kala-azar) Leishmania donovani. Think "young malnourished child" | Sandfly | Macrophages containing amastigotes | sodium stibogluconate | Flagellated |
Malaria: desrcribe different kinds | Plasmodium (vivax, ovale, malariae, falciprum); Symptoms: cyclic fever, headache, anemia, splenomegaly; Severe: cerebral falciprum; Vivax/ovalae= dormant forms in liver (hypnozoites) --> relapsing malaria | Mosquito (Anopheles) | Blood smear | Chloroquine (primaquine to prevent relapse caused by vivax, ovale, sulfadoxine+ pyrimethamine, mefloquine, quinine | Trophozoite ring form in RBC, RBC schizont (bag of nuclei) with merozites (with cell membranes) |
Fever, hemolytic anemia, predominantly in Northeastern US | Babesiosis: Babesia | Ixodes tick | Blood smear, no RBC pigment, appears like "Maltese cross" | Quinine, clindamycin | Maltese cross and ring forms |
Severe diarrhea in AIDS, Mild disease in non-immunocompromised host | Cryptosporidium | Cysts in water | Cysts on acid fast | None | |
Brain abcess in HIV, birth defects (ring-enhancing lesion) | Toxoplasma gondii | Cysts in meat/cat feces, crosses placenta (pregnant women should avoid cats | Serology, biopsy | Sulfadiazine + pyrimethamine | |
Bloody diarrhea (dysentery) liver abcess, RUQ pain | Amebiasis: Entamoeba histolytica | Cysts in water | Serology and/or trophozites or cysts in stool; RBCs in cytoplasm of entamoeba | Metronidazole and iodoquinol | |
Rapidly fatal meningoencephalitis | Naegleria fowleri | Swimming in freswater lakes (enter via cribiform plate) | Amoebas in spinal fluid | None | |
Bloating, flatulence, foul-smelling diarrhea (often seen in campers/hikers) | Giardiasis (Giardia lamblia); both trophozoite/cyst form | Cysts in water | Trophozoites or cysts in stool | Metronidazole | |
Foul-smelling greenish discharge, itching, burning | Vaginitis: Trichomonas | Sexual | Trophozoites (motile) wet mount | Metronidazole | |
Dilated cardiomyopathy, megacolon, megaesophagus); predominantly in South America | Chaga's disease (Trypanosoma cruzi) | Reduviid bug (kissing bug) | Blood smear | Nifurtimox | |
Enlarged lymph nodes, recurring fever (due to antigenic variation) somnolence, coma | African Sleeping sickness (trypansoma gambiense, rhodesiense) | Tsetse fly | Blood smear | SURamin for blood borne disease, MELArsoprole for CNS penetration(it SURe is nice to go to sleep; MELAtonin helps sleep) |