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Ch.4

Psychopharmacology and Parmacokinetics

QuestionAnswer
Psychopharmacology study of the effects of drugs on the nervous system and behavior.
Drug Effect Changes drug produces in an animal's physiological processes and behavior
Sites of Action location at which molecules of drug interact with molecules located on or in cells of the body, thus affecting biochemical processes of these cells
exogenous means produced from outside the body
Pharmacokinetics movement of drugs, including process by which drugs are absorbed, distributed in the body, metabolized, and excreted
intraperitoneal (IP) absorbed through abdominal wall
intracerebral administration drug directly to brain
intracerebralventricular some antibiotics, used rarely in humans, primarily to deliver antibiotics directly to the brain
lipid solubility the ability of fat-based molecules to pass through cell membranes
blood brain barrier is a barrier that is only for water soluble molecules, only oil/fat based molecules can pass through
dose response curve plot graph used to measure the effectiveness of a drug
therapeutic index measure of drug's margin of safety; ratio of dose that produces desired effect in 50% of animals and one that produces toxic effects in 50% of animals. The lower the therapeutic index, the narrower margin of safety
Affinity Readiness with which two molecules join together
Antagonists drugs that block or inhibit postsynaptic effects
Agonists drugs that facilitate postsynaptic effects.
Sites of drug action 1. Production of NT 2. Storage and Release of NT 3. On post synaptic receptors 4. Reuptake or destruction of NT's
Created by: Dalea
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