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Ch.4
Neurotransmitters and neuromodulators
term | Functions |
---|---|
Amino Acids | Glutamate, GABA, Glycine |
monoamines | Dopamine, norepinephrine, serotonin, histamine |
Peptides | Endophines, Enkephalines |
Glutamate | excitatory; interacts with other neurotransmitter systems-(CNS) |
GABA | Inhibitory; interacts with other neurotransmitter systems-(CNS) |
Acetylcholine (ACh) | Learning, memory, and REM sleep-(CNS) muscle contraction-(PNS) |
Dopamine | Voluntary movement, attention, learning, reinforcement, planning, and problem solving-(CNS) |
Norepinephrine/Epinephrine | Viligance-(CNS) Autonomic nervous system regulation such as heart rate and blood pressure(PNS) |
Serotonin | Mood regulation, eating, sleep, dreaming, arousal, and impulse control (CNS) Involved in the enteric nervous system (digestive tract)-(PNS) |
Histamine | Wakefulness-(CNS) Immune response-(PNS) |
Opiods | Reinforcement, pain modulation-(CNS) Pain modulation-(PNS) |
Endocannabinoids | Appetite regulation-(CNS) Immune response-(PNS) |
Glutamate | synthesized from a precursor (glutamine) by an enzyme (glutaminase) in one step |
Glutamate receptors | 4 major types of receptors 1. NMDA 2. AMPA 3. kainate 4.Metabotropic |
GABA | primary receptor site-drug muscimol-agonist secondary receptor site - benzodiazepines |
Monoamine family - 5 chemicals | Dopamine, Norepinephrine, Epinephrine, Serotonin, Histamine |
Catecholamines | 1.Dopamine 2.Norepinephrine 3.Epinephrine |
Indolamine | Serotonin |
Ethylamine | Histamine |
Tyrosine | precursor for dopamine Amino acid obtained from diet |
MAO | destroys monoamines (Dopamine, NE and 5-HT) |
Deprenyl | antagonist - MAO inhibitor-blocks the destruction of dopamine |
MAOI's | agonists |
Norepinephrine (NE) | aka. Noradrenalin |
NE synthesis | occurs inside the vesicles- vesicles are filled with dopamine; then an enzyme converts DA into NE |
axonal varicosities | beadlike swellings of the axonal branches |
NE release | release from axonal varicosities |
monoamine oxidase (type A) | destroys excess NE in terminal buttons |
andrenergic receptors | metobotropic receptors (A1,A2, B1, B2) sensitive to norepinephrine and epinephrine produce both excitatory and inhibitory effects |
locus coeruleus | nucleus located in the dorsal pons (most important noradrenergic neurons) |
noradrenergic neurons | involved in sexual behavior and in the control of appetite |
Serotonin (5-HT) | aka (5-hydroxytryptamine) |
Tryptophan | precursor for serotonin |
tryptophan hydroxylase | enzyme that acts on tryptophan producing 5-HTP (5-hydroxytryptophan) |