click below
click below
Normal Size Small Size show me how
Infectious disease_P
Poola's 2nd exam review- infectious diease and epidemiology
Question | Answer |
---|---|
• Infectious disease | “An illness due to a specific infectious agent or its toxic products that arises through transmission of that agent or its products from an infected person, animal, or reservoir to a susceptible host, either directly or indirectly through an intermediate |
• Parasitic disease | An infection caused by a parasite, which “…is an organism that lives on or in a host organism and gets its food from or at the expense of its host.” Example: amebiasis |
• Epidemiologic triangle | agent, host, environment |
- agent | A factor—such as a microorganism, chemical substance, or form of radiation—whose presence, excessive presence, or (in deficiency diseases) relative absence is essential for the occurrence of a disease….” |
- Host | A person or other living animal, including birds and arthropods, that affords subsistence or lodgment to an infectious agent under natural conditions |
- Environment | The domain in which disease-causing agents may exist, survive, or originate |
• infectious disease agents | bacteria, rickettsia, viruses, fungi, parasites, and prions• vector: any animate living insect or animals that is involved with transmission of disease agent |
• vector | any animate living insect or animals that is involved with transmission of disease agent |
• Infectivity | The capacity of an agent to enter and multiply in a susceptible host and thus produce infection or disease |
• Virulence | severity of the disease produced, i.e., whether the disease has severe clinical manifestations or is fatal in a large number of cases. |
• Toxin | Some infectious disease agents, instead of acting directly, produce a toxin that causes illness. usually refers to a toxic substance made by living organisms. ( botulism) |
• Immunity | refers to the host’s ability to resist infection by the agent ( may be active or passive) |
• Antigen | A substance that stimulates antibody formation, e.g., a microbial agent |
• Herd immunity | The resistance of an entire community to an infectious agent as a result of the immunity of a large proportion of individuals in that community to the agent |
• Incubation period | Time interval between invasion by an infectious agent and the appearance of the first sign or symptom of the disease• |
Subclinical Infection= inapparent infection | An infection that does not show obvious clinical signs or symptomseg. hepatitis A infections among children |
Generation Time | The time interval between lodgment of an infectious agent in a host and the maximal communicability of the host |
Carrier | “A person or animal that harbors a specific infectious agent without discernible clinical disease, and which serves as a potential source of infection.” |
Index Case | Used in an epidemiologic investigation of a disease outbreak to denote the first case of a disease to come to the attention of authorities |
The first case of a disease to come to the attention of authorities is the | index case |
Endemic | a infectious disease agent that is habitually present in an environment (either geographic or population group)Example: Plague is endemic among certain species of rodents in the western U.S |
Reservoir | A place where infectious agents normally live and multiplyCan be human beings, animals, insects, soils, or plants |
Zoonosis | An infection or infectious agent transmissible under natural conditions from vertebrate animals to humans |
portal of exit | site from which the agent leaves that person's body eg. respiratory passages, alimentary canal, genitourinary system, skin lesions |
vehicle-borne infections | result from contact with vehicles- contaminated, nonmoving obejcts (fomites, unsanitary food, impure water) |
portal of entry | site where the agent enters the body eg. skin wound |
fomite | an inanimate object that carries infectious disease agents eg. classroom doorknob, discarded tissues |
airborne infections | invove the spread of droplet nuclei (particles) that are present in the air eg. infections caused by stirring up dust that carries fungi or microbes |
vector-borne infection | transmission of an infectious disease agent may happen when the vector feeds on a susceptible host |
vector | an animate, living insect or animal that is involved with the transmission of disease agents |
sexually transmitted diseases examples | HIV/AIDS, gonococcal infections, chlamydial genital infections |
foodborne illness | biologic agents of foodborne illness include bacteria, parasites, viruses, and prions ( linked to mad cow disease) |
bacterial agents | campylobacter, clostridium botulinum, salmonella |
vector-borne disease examples | bacterial: lyme disease (tick)arthropod-borne (arboviral) disease: eastern equine encephalitis ( mosquito)parasitic disease: malaria (mosquito) |
vaccine-Preventable diseases (VPDs) | conditions that can be prevented by vaccination ( immunization) eg. diptheria, tetanus, whooping cough, hep A and B |
zoonotic disease | diseases transmitted from vertebrae animals to human beings eg. rabies, antrhax, avian influenza, hantavirus pulmonary syndrome, toxoplasmosis, tularemia ( rabbit fever) |
Emerging Infectious Diseases(Emerging Infections) | an infectious disease that has newly appeared in a population or that has been known for some time but is rapidly increasing in incidence or geographic range eg. hepatitis, E.coli O157:H7 |
Bioterrorism-Related Diseases | aka. bioterrorism attack, the deliberate release of viruses, bacteria, or other germs used to cause illness or death in people, animals, or plants eg.anthrax |
epidemic curve | a graphing plotting of the distribution of cases by time of onset. may reflect a common-source epidemic or a point-source epidemic |
methods of outbreak investigation | clinical observations, epidemic curve, incubation period, attack rate, case mapping, hypothesis formulation and confirmation, draw conclusion |
Case mapping | Some investigations may use computer software to show the location of cases. |
Hypotheses | Using the information that has been gathered, the epidemiologist may formulate a hypothesis regarding the causative agent. |
Draw a conclusion | Plan for the prevention of future outbreaks. |
surveillance | primary way to track diseases over time, allowing us to compare places, time periods, and assess presence of outbreaks; ongoing, systematic collection, analysis, interpretation of data regarding health-related event for use and to improve health |
cancer research, health services access, environmental exposure, behavior, adverse events following receipt of drugs, vaccines etc | surveillance can be used in |
characteristics of a good surveillance system | simplicity, flexibility, data quality, acceptability, sensitivity, predictive value positive, representativeness, timeliness, stability |
biases encountered by surveillance system | reporting bias, interviewer bias, ascertainment bias, volunteer bias, other selection biases, social desirability bias, misclassification, due to issues with case definition |