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Micro Final-1
Antibiotics
Question | Answer |
---|---|
Penicillin | G+ BL-; syphilis, N.meningitidis; BL- N. gon |
Ampicillin | Staph/Strep, Enterobactericiae (Ecoli/Proteus mirabilis); increasing G- |
Amoxicillin | increasing G-, wimpy Enterobactericiae (Ecoli, P.mirabilis); Staph/Srep |
Imipenem | zwitterion, smallest, gram - (requires calcium something addition) |
Meropenem | zwitterion, smallest, gram - |
Combos (Ticarcillin/Piper/Carbenicillin) | HI, Moraxella catarrhalis, Neisseria, Staph aureus |
B lactamase inhibitor pairing combos | amox+clav; amp+sulbact |
Nafcillin/Methicillin | gram +, staph/strep (no gram negatives) |
First Gen Cephalosporins | CEPHALEXIN/CEFAZOLIN; B-lactamase + Staph (SSS-->staph/strep/surgeries) (no enterococci/no MRSA) |
Sec Gen Ceph | cefuroxime; cefotetan; G- bacilli (enterobactericiae (no enterobacter/no pseudo) |
Thrid Gen Cephalosporins | ceftazidime/cefotaxime/cefoperazone/ceftriaxone; pseudomonas, G- |
Fourth Gen Cephalosporins | cefepime; pseudomonas G- |
Aztreonnam | monobactam; G- aerobes, no anaerobes, no gram neg, no toxicity (like aminoglycosides without toxicity) |
Vancomycin | gram positives; no gram positive meningitis (no BBB); MRSA; no VRE; no VRSA |
What are the 2 macrolides | Erythromycin and Azithromycin |
Erythromycin | Mycoplasma, Chlamydia, Legionella, Strep (substitute for penn); upsets stomach 50s |
Azithromycin | 50s; mycoplasma, chlamydia, legionella, strep, HI, moraxella catarrhalis, Neisseria gon; emperic: sinusitus, otitis media, pneumonia 50s |
Clindamycin | G+/G- anaerobes, MSSA, Streptococci, B frag; 50s (no enterococci; no g- aerobes) |
Oxazolidanones | Linezolid 50s |
Linezolid | 50s; VRSA; VRE; enterococcus facealis; good for resistant staph, enterococci, pneumococci |
Tetracycline | 30s; tetra, mino, doxy; G+/G-; chlamydia, legionella, Rickettsia, Mycoplasma |
Aminoglycosides | 30s; gentamicin, neomycin (topical), amikacin, tobramycin, streptomycin; aerobic G-, G+ w/pen (enterococci/enterobactericiae) |
Chloramphenicol | chlamydia, ehrlichia, rickettsia, aplastic anemia (ER when Tetra won't work) |
Quinolones | Cipro, Levofloxacin--DNA gyrase inhibitors (topoisomerase) |
Cirpofloxacin | aerobes, FA, no anerobes, empiric CAP: Mycoplasma, M cat, chlamydia pneum, Legionella pneumophilia, Strep pnemo (no MRSA); MSSA, g- aerobes (oral pseudomonas) |
oral pseudomonas | cipro |
Metronidazole | synthetic; parasites (trich, giardia, entambeomeba; obligate anaerobes; (no propiones, no actinomyces); clostridium, pepto, bacteroides, porphrymonas, all tissues (brain ab, abd ab, C dif colitis) no aerobic (treat with second tx for anaerobic with metro) |
Bactrim (TMP-SMX) | aerobes, no obligate anaerobes, protozoans; UTI, otitis media, pneumocystis pneumonia (fungal), travelers diarrhea, chronic bronchitis (acute exacerbations) |
pneumocystis pneumonia | Bactrim |
travler's diarrhea | bactrim |
SMX inhibits what? | PABA analogue (synthetase) |
TMP inhibits what? | DHF reductase |