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FA Review
First Aid Rapid Review
Question | Answer |
---|---|
Abdominal pain, ascites, hepatomegaly | Budd-Chiari syndrome (Post-Hepatic venous thrombosis) |
Abdominal pain, diarrhea, leukocytosis, recent antibiotic use | Clostridium difficile infection |
Achilles tendon xanthoma | Familial Hypercholesterolemia |
Decreased LDL receptor signaling | Familial Hypercholesterolemia |
Adrenal hemorrhage, hypotension, DIC | Waterhouse-Friderichsen syndrome |
Meningococcemia | Waterhouse-Friderichsen syndrome |
Anaphylaxis following blood transfusion | IgA deficiency |
Anterior "drawer sign" positive | Anterior cruciate ligament (ACL) injury |
Arachnodactyly, lens dislocation (upward), aortic dissection, hyperflexible joints | Marfan syndrome |
Fibrillin defect | Marfan syndrome |
Athlete with polycythemia | Secondary to EPO injection |
Back pain, fever, night sweats | Pott disease |
Vertebral TB | Pott disease |
Bilateral acoustic schwannomas | Neurofibromatosis type 2 |
Bilateral hilar adenopathy, uveitis | Sarcoidosis |
What kind of granulomas are seen in Sarcoidosis? | Non-caseating granulomas |
Black eschar on face of patient with diabetic ketoacidosis | Mucor or Rhizopus fungal infection |
Blue sclerae | Osteogenesis imperfecta |
Type I collagen defect | Osteogenesis imperfecta |
Bluish line on gingiva | Burton line |
Lead poisoning is seen with which kind of gingival problem? | Burton line |
Bone pain, bone enlargement, arthritis | Paget disease of bone |
Increased osteoblastic and osteoclastic activity | Paget disease of bone |
Bounding pulses, wide pulse pressure, diastolic heart murmur, head bobbing | Aortic regurgitation |
"Butterfly" facial rash and Raynaud phenomenon in a young female | Systemic Lupus Erythematosus (SLE) |
Cafe-au-lait spots, Lisch nodules (iris hamartoma), cutaneous neurofibromas, pheochromocytomas, optic gliomas | Neurofibromatosis type 1 |
Cafe-au-lait spots (unilateral), polyostotic fibrous dysplasia, precocious puberty, multiple endocrine abnormalities | McCune-Albright syndrome |
Mosaic G-protein signaling mutation is seen with? | McCune-Albright syndrome |
Calf pseudohypertrophy | Muscular dystrophy |
What is the most common muscular dystrophy? | Duchenne muscular dystrophy |
What is Duchenne Muscular dystrophy caused by? | X-linked recessive frameshift mutation of dystrophin gene |
Cervical lymphadenopathy, desquamating rash, coronary aneurysms, red conjunctiva and tongue, hand-foot changes | Kawasaki disease |
What is the treatment for Kawasaki disease? | IVIG and aspirin |
"Cherry-red spots" on macula | Tay-Sachs, Niemann-Pick, central retinal artery occlusion |
Ganglioside accumulation | Tay-Sachs |
Sphingomyelin accumulation | Niemann-Pick |
Chest pain on exertion | Angina |
Stable Angina: | Chest pain with moderate exertion |
Chest pain with minimal exertion or at rest | Unstable angina |
Chest pain, pericardial effusion/friction rub, persistent fever following MI | Dressler syndrome |
Autoimmune-mediated post-MI fibrinous pericarditis, 2 weeks to several months after acute episode | Dressler syndrome |
Chest pain with ST depression on EKG | Unstable angina or NSTEMI |
Chest pain with ST depression on EKG , positive troponins | NSTEMI |
Chest pain with ST depression on EKG, negative troponins | Unstable angina |
Child uses arms to stand up from squat | Duchenne muscular dystrophy |
Positive Gowers sign | Duchenne muscular dystrophy |
Child with fever later develops red rash on face that spreads to body | Erythema infectiosum/fifth disease |
"Slapped cheeks" appearance, caused by parvovirus B19 | Erythema infectiosum/fifth disease |
Another term used for Erythema Infectiosum? | Fifth disease |
Chorea, dementia, caudate degeneration | Huntington disease |
Autosomal dominant CAG repeat expansion | Huntington disease |
Chorioretinitis, hydrocephalus, intracranial calcifications | Congenital toxoplasmosis |
Chronic exercise intolerance with myalgia, fatigue, painful cramps, myoglobinuria | McArdle disease |
Skeletal muscle glycogen phosphorylase deficiency | McArdle disease |
Cold intolerance | Hypothyroidism |
Conjugate horizontal gaze palsy, horizontal diplopia | Internuclear ophthalmoplegia |
Damage to MLF | Internuclear ophthalmoplegia |
Continuous "machine-like" heart murmur | PDA |
Which murmur is closed with Indomethacin? | PDA |
PDA is kept open with: | PGE analogues |
Cutaneous/dermal edema due to connective tissue deposition | Myxedema |
What conditions are associated with Myxedema? | Hypothyroidism, Graves disease ([pretibial]) |
Cutaneous flushing, diarrhea, bronchospasm | Carcinoid syndrome |
Right-sided cardiac valvular lesions, increased 5-HIAA | Carcinoid syndrome |
Dark purple skin/mouth nodules in a patient with AIDS | Kaposi sarcoma |
Which virus is associated with Kaposi sarcoma? | HHV-8 |
Deep, labored breathing/hyperventilation and Hx of increased HbA1 | Diabetic ketoacidosis |
Kussmaul respiration are common in which diabetic complication? | Diabetic ketoacidosis |
Dermatitis, dementia, diarrhea | Pellagra |
Niacin (vitamin B3) deficiency | Pellagra |
Dilated cardiomyopathy, edema, alcoholism or malnutrition | Wet beriberi |
Thiamine (Vit B1) deficiency and Dilated cardiomyopathy | Wet beriberi |
Dog or cat bite resulting in infection | Pasteurella multocida |
Cellulitis art inoculation site | Pasteurella multocida |
Dry eyes, dry mouth, arthritis | Sjogren syndrome |
Autoimmune destruction of exocrine glands | Sjogren syndrome |
Dysphagia (esophageal webs), glossitis, iron deficiency anemia | Plummer-Vinson syndrome |
What is a possible complication of Plummer-Vinson syndrome? | Esophageal Squamous Cell carcinoma |
Elastic skin, hypermobility of joints, and increased bleeding tendency | Ehlers-Danlos syndrome |
Type V collagen defect, type III collagen defect seen in vascular subtype of ED | Ehlers-Danlos syndrome |
Enlarged, hard left supraclavicular node | Virchow node |
Episodic vertigo, tinnitus, hearing loss | Meniere disease |
Erythroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells | Mycosis fungoides or Sezary syndrome |
Cutaneous T cell lymphoma | Mycosis fungoides |
Mycosis fungoides + malignant T cells in the blood | Sezary syndrome |
Facial muscle spasm upon tapping | Chvostek sign |
Positive Chvostek sign | Hypocalcemia |
Fat, female, forty, and fertile | Cholelithiasis |
Medical terminology for gallstones | Cholelithiasis |
Fever, chills, headache, myalgia following antibiotic treatment for syphilis | Jarisch-Herxheimer reaction |
Rapid lysis of spirochetes results in Endotoxin release | Jarisch-Herxheimer reaction |
Fever, cough, conjunctivitis, coryza, diffuse rash | Measles |
Fever, night sweats, weight loss | B symptoms (staging) of lymphoma |
Fibrous plaques in soft tissue of penis wit abnormal curvature | Peyronie disease |
Connective tissue disorder of the penis | Peyronie disease |
Golden brown rings around peripheral cornea | Wilson disease |
Kayser-Fleischer rings due to copper accumulation | Wilson disease |
Gout, intellectual disability, self-mutilating behavior in a boy | Lesch-Nyhan syndrome |
HGPRT deficiency, X-linked recessive | Lesch-Nyhan syndrome |
Hamartomatous GI polyps, hyperpigmentation of mouth/feet/hands/genitalia | Peutz-Jeghers syndrome |
Inherited, benign polyps can cause bowel obstruction; increased cancer risk, mainly GI | Peutz- Jeghers syndrome |
Hepatosplenomegaly, pancytopenia, osteoporosis, aseptic necrosis of femoral head, bone crises | Gaucher disease |
Glucocerebrosidase deficiency | Gaucher disease |
Hereditary nephritis, sensorineural hearing loss, cataracts | Alport syndrome |
Mutation in collagen IV | Alport syndrome |
Hyperphagia, hypersexuality, hyperorality, hyperdocility | Kluver-Bucy syndrome |
Bilateral amygdala lesion | Kluver-Bucy syndrome |
Hyperreflexia, hypertonia, Babinski sign present | UMN damage |
Hyporeflexia, hypotonia, atrophy, fasciculations | LMN damage |
Situs inversus, chronic sinusitis, bronchiectasis, infertility | Kartagener syndrome |
Dynein arm defect affecting cilia | Kartagener syndrome |
Slow, progressive weakness in boys | Becker muscular dystrophy |
X-linked missense mutation in dystrophin; less severe than Duchenne | Becker muscular dystrophy |
Infant with cleft lip/palate, microcephaly or holoprosencephaly, polydactyly, cutis aplasia | Patau syndrome |
Trisomy 13 | Patau syndrome |
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect | Edwards syndrome |
Trisomy 18 | Edwards syndrome |
Single palmar crease | Down syndrome |
Swollen gums, mucosal bleeding, poor wound healing, petechiae | Scurvy |
Vitamin C deficiency causes: | Scurvy |
What is the biochemical deficient in Vitamin C deficiency? | Cannot hydroxylate proline/lysine for collagen synthesis |
Infant with hypoglycemia, hepatomegaly | Cori disease or Von Gierke disease |
Cori disease is due to missing | Debranching enzyme |
Von Gierke disease is due to missing | Glucose-6-phosphatase deficiency |
Myopathy, exercise intolerance, and infantile hypertrophic cardiomyopathy | Pompe disease |
What enzyme deficiency causes Pompe disease? | Lysosomal a-1, 4-glucosidase |
Male child, recurrent infections, no mature B cells | Bruton disease |
X-linked agammaglobulinemia | Bruton disease |
Recurrent cold (noninflamed) abscesses, unusual eczema, high serum IgE | Hyper-IgE syndrome |
What is another name for Hyper-IgE syndrome? | Job syndrome |
Neutrophil chemotaxis abnormality is seen inJ: | Hyper-IgE syndrome |
"Strawberry tongue" | Scarlet Fever and Kawasaki disease |
Red "currant jelly" sputum in alcoholic or diabetic patients | Klebsiella pneumoniae pneumonia |
Large rash with bull's-eye appearance | Erythema chronicum migrans form Ixodes tick bite |
What organism causes Lyme disease? | Borrelia |
Indurated, ulcerated genital lesion, and NON-painful | Chancre |
What organism and disease is associated with genital chancre? | Primary syphilis caused by Treponema pallidum |
Induced, ulcerated genital lesion, painful and with exudate | Chancroid |
What is the most common cause of a chancroid? | Haemophilus ducreyi infection |
Pupil accommodates but does not react | Argyll Robertson pupil |
What condition is seen with Argyll Robertson pupil? | Neurosyphylis |
Smooth, moist, painless, wart-like white lesions on genitals | Condylomata lata |
Condylomata late is associated with which stage of syphilis? | Second stage |
"Worst headache of my life" | Subarachnoid hemorrhage |
Weight loss, diarrhea, arthritis, fever, adenopathy | Whipple disease |
What condition is caused by Tropheryma whipplei? | Whipple disease |
Vomiting blood following gastroesophageal lacerations | Mallory-Weiss syndrome |
Mallory-Weiss syndrome is often seen in: | Alcoholics and bulimic patients |
Vascular birthmark of the face | Nevus flammeus |
What is the classical description of vascular birthmark in Sturge-Weber syndrome | Port-wine stain |
Benign, but associated with Sturge-Weber syndrome? | Nevus flammeus |
Urethritis, conjunctivitis, arthritis in a male | Reactive arthritis associated with HLA-B27 |
Unilateral facial drooping involving forehead | LMN facial nerve (CN VII) palsy |
Which kind of Motor neuron damage of CN VII palsy spare the forehead? | UMN |
Toe extension/ fanning upon plantar scape | Babinski sign |
Adult UMN lesion is often presented with a positive | Babinski sign |
Thyroid tumors, pheochromocytoma, ganglioneuromatosis | MEN 2B |
Autosomal dominant RET mutation | MEN 2A and MEN 2B |
Thyroid and parathyroid tumors, pheochromocytoma | MEN 2A |
Telangiectasias, recurrent epitalis, skin discoloration, arteriovenous malformations, GI bleeding, hematuria | Osler-Weber-Rendu syndrome |
Systolic ejection murmur (crescendo-decrescendo) | Aortic stenosis |
Swollen, hard, painful finger joints | Osteoarthritis |
Osteophytes on PIP (Bouchard nodes), DIP (Heberden nodes) | Osteoarthritis |
What two classical joint nodes are associated with Osteoarthritis? | Bouchard nodes (PIP) and Heberden nodes (DIP) |
Sudden swollen/painful big toe joint, tophi | Gout/podagra |
What kind of electrolyte imbalance is associated with the development of Gout? | Hyperuricemia |
Streak ovaries, congenital heart disease, horseshoe kidney, cystic hygroma at birth, short stature, webbed neck, lymphedema | Turner syndrome |
45, XO | Turner syndrome |
Splinter hemorrhages in fingernails | Bacterial endocarditis |
Small, irregular red spots, on buccal/lingual mucosa with blue-white centers | Koplik spots |
Koplik spots are associated with: | Measles virus |
Another name for rubeola virus | Measles virus |
Skin hyperpigmentation, hypotension, fatigue | Primary adrenocortical insufficiency |
What is the common name for Primary adrenocortical insufficiency? | Addison disease |
What hormonal imbalances are primary in Addison disease? | Increased ACTH and Increased a-MSH production |
The hyperpigmentation in Addison disease is due to: | Increased a-MSH production |
Short stature, cafe au lait spots, thumb/radial defects, increased incidence of tumors/leukemia, aplastic anemia | Fanconi anemia |
Genetic loss of DNA crosslink repair; often progresses to AML | Fanconi anemia |
Severe jaundice in neonate | Crigler-Najjar syndrome |
Severe congenital unconjugated hyperbilirubinemia | Crigler-Najjar syndrome |
Retinal hemorrhages with pale centers | Roth spots |
Name of ocular signs in Bacterial endocarditis | Roth spots |
Resting tremor, rigidity, akinesia, postural instability, shuffling gait | Parkinson disease |
Loss of dopaminergic neurons in substantia nigra pars compacta | Parkinson disease |
Renal cell carcinoma (bilateral), hemangioblastomas, angiomatosis, pheochromocytoma | von-Hippel-Lindau disease |
Red urine in the morning, fragile RBCs | Paroxysmal nocturnal hemoglobinuria |
Red, itchy, swollen rash of nipple/areola | Paget disease of the breast |
Sign of underlying breast neoplasm | Paget disease of the breast |
Red "currant jelly" stools | Acute mesenteric ischemia (adults), intussusception (children) |
Rash on palms and soles | Coxsackie A, Secondary syphilis, Rocky Mountain spotted fever |
Rapidly progressive limb weakness that ascends following GI/upper respiratory infection | Guillain-Barre syndrome |
Acute inflammatory demyelinating polyradiculopathy subtype | Guillain-Barre syndrome |
Ptosis, miosis, anhidrosis | Horner syndrome |
Pruritic, purple, polygonal planar papules and plaques (6 P's) | Lichen planus |
Polyuria, renal tubular acidosis type II, growth failure, electrolyte imbalances, hypophosphatemic rickets | Fanconi syndrome |
Multiple combined dysfunction of the proximal convoluted tubule | Fanconi syndrome |
Pink complexion, dyspnea, hyperventilation | Emphysema |
"Pink puffer", | Emphysema |
Smoking emphysema | Centriacinar emphysema |
Alpha-1-deficiency emphysema | Panacinar emphysema |
Periorbital and/or peripheral edema, proteinuria (>3.5g/day), hypoalbuminemia, hypercholesterolemia | Nephrotic syndrome |
Pancreatic, pituitary, parathyroid tumors | MEN 1 |
Palpable purpura on buttocks/legs, joint pain, abdominal pain (child), hematuria | Henoch-Schonlein purpura |
IgA vasculitis affecting skin and kidneys | Henoch-Schonlein purpura |
Painless jaundice | Cancer of the pancreatic head obstruction bile duct |
Painless erythematous lesions on palms and soles | Janeway lesions |
Infective endocarditis, septic emboli/microabscesses | Janeway lesions |
Jaundice, palpable distended non-tender gallbladder | Courvoisier sign |
Distal malignant obstruction of biliary tree | Courvoisier sign |
Lucid interval after traumatic brain injury | Epidural hematoma |
Middle meningeal rupture | Epidural hematoma |
Mucosal bleeding and prolonged bleeding time | Glanzmann thrombasthenia |
Defect in platelet aggregation due to lack of GpIIb/IIIa | Glanzmann thrombasthenia |
Muffled heart sounds, distended neck veins, hypotension | Beck triad of cardiac tamponade |
Multiple colon polyps, osteomas/soft tissue tumors, impacted/supernumerary teeth | Gardner syndrome |
Subtype of FAP | Gardner syndrome |
Neonate with arm paralysis following difficult birth | Erb-Duchenne palsy |
Superior trunk [C5-C6] brachial plexus injury | Erb-Duchenne palsy |
What is the classical sign of Erb-Duchenne palsy? | "waiter's tip" |
No lactation postpartum, absent menstruation, cold intolerance | Sheehan syndrome |
Pituitary infarction | Sheehan syndrome |
Painful blue fingers/toes, hemolytic anemia | Cold agglutinin disease |
Autoimmune hemolytic anemia caused by Mycoplasma pneumoniae, infectious mononucleosis, CLL | Cold agglutinin disease |
Painful fingers/toes changing color form blue to white to red with cold or stress | Raynaud phenomenon |
Vasospasms in extremities | Raynaud phenomenon |
Severe RLQ pain with palpation of LLQ | Rovsing sign |
(+) Rovsing sign | Acute appendicitis |
Severe RLQ pain with deep tenderness | McBurney sign |
What is the most common sign in acute appendicitis? | McBurney sign |