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Fetal Chr. Abnormal
PB 226: Screening for Fetal Chromosomal Abnormalities
Question | Answer |
---|---|
Incidence of Trisomy 21 | 1 : 700 |
Incidence of Trisomy 18 | 1 : 3,000 |
Incidence of Trisomy 13 | 1 : 6,000 |
Incidence of Turners Syndrome | 1 : 2,500 |
Detection rate of trisomy 21 for cfDNA | 99% (false positive rate of 0.1%) |
Serum analytes on 1st tri screen | hCG, PAPP-A, AFP |
Serum analytes on Quad screen | hCG, AFP, Inhibin A, Estriol |
Detection rate of trisomy 21 for Quad screen | 80% (false positive rate of 5%) |
Integrated Screening | 1st tri screen + Quad Screen with results given after quad screen. |
Sequential Screening | 1st tri screen + Quad Screen with PRELIM results given after 1st tri screen with disadvantage of slightly higher false positive rate |
Contingent Screening | 1st tri screen results categorized as low/med/high risk and high risk results have a Quad screen performed |