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DRUG ICARDS

Ceftriaxone

QuestionAnswer
Ceftriaxone mechanism of action Ceftriaxone is a cephalosporin antibiotic with broad activity against gram-negative and gram-positive bacteria. It inhibits production of the bacterial cell wall, causing bacteria to die.
Ceftriaxone indications (2) -Suspected meningococcal septicaemia -Sepsis, where cefazolin is not indicated, and: the patient is aged great er or equal to 12 years old and one clinical feature indicating antibiotics are present, and time to hospital is greater than 30 minutes
Ceftriaxone contraindications -Known severe allergy to cephalosporins
Ceftriaxone cautions -None
Preganancy Should be administered if indicated.
Dosage -2g IV for an adult -2g im for an adult if IV access cannot be obtained (meningoccocal septicaemia only) -See pediatric drug dose table
Administration IV- dissolve 4ml then dilute to total of 10 ml. disregard extra for child. administer IV of 1-2 minutes preferably into a running line. IM- dilute with 4ml, draw up into 2 syringes, disregard extra for child
Common adverse effects- Onset- Duration - -None -30-60mins -24 hrs
Preparation ampoule containing 2g.
Pharmacokinetics -50% excreted in urine and 50% in bile. -Neither renal impairment nor hepatic impairment alter the initial loading dose
Additional information As meningococcal bacteria die, they release endotoxins. The body's immune response to endotoxins can cause profound worsening of shock following antibiotic administration.
Created by: nicolaprice01
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