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DRUG ICARDS
Methoxyflurane
Question | Answer |
---|---|
Mechanism of action | Inhaled analgesic Mechanism is unclear |
Indications | Moderate to severe pain, particularly when there will be a significant delay in an opiate being administered |
Contraindication (4) | -Known severe allergy -Personal or family history of malignant hyperthermia -Known renal impairment -Methoxyflurane administered within the last week |
Cautions (4) | -Age greater or equal to 75 years, particularly if frail -Pre-eclampsia, can worsen renal impairment -Administration within a confined space -Acute exacerbation of chronic pain |
Pregnancy | Can cause temporary drowsiness |
Dosage | 6 ml for greater or equal to 12 years 3 ml for child less than 12 years |
Common adverse effects | -sedation -Feeling light headed |
Onset duration | 1-2 minutes 2-3 minutes |
Pharmacokinetics | - approximately 20% is exhaled, remainder is metabolised in the liver. -One of the metabolites is fluoride ions, high amounts have been associated with renal impairment and this is the reason for know renal impairment being a contraindication |