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G-protein 2nd messen

GP second messengers

QuestionAnswer
List of adrenergic receptors: α1, α2, ß1, ß2, ß3
List of cholinergic receptors: M1, M2, M3
List of Dopamine receptors D1, D2
List of Histamine receptors H1, H2
List of Vasopressin receptors: V1, V2
Which receptors have q-protein class? H1, α1, V1, M1, M3
Which receptors have i-protein class? M2, α2, D2
Which receptors have s-protein class? ß1, ß2, ß3, D1, H2, V2
What are the major functions of α-1 adrenergic receptors? ↑ vascular smooth muscle contraction, ↑ pupillary dilator muscle contraction (mydriasis), ↑ intestinal and bladder sphincter muscle contraction
↑ vascular smooth muscle contraction α1
What are the major functions of α-2 adrenergic receptors? ↓ sympathetic (adrenergic) outflow, ↓ insulin release, ↓ lipolysis, ↓ aqueous humor production and ↑platelet aggregation.
Which adrenergic receptor causes a ↓ in sympathetic outflow? α-2
What are the major functions of ß-1 receptors? ↑ HR, ↑ contractility, ↑ renin release and lipolysis
What are the major functions of ß-2 receptors? VASODILATION and BRONCHODILATION, ↑: Lipolysis, insulin release, glycogenolysis, aqueous humor production, cellular K+ uptake ↓: in uterine tone (tocolysis)
What are the major functions of ß-3 receptors? ↑↑↑ in lipolysis, thermogenesis in skeletal muscle, and bladder relaxation
Which ß-receptors is associated with a ↑ in bladder relaxation? ß-3
Mediates higher cognitive functions, stimulates enteric NS: M1
What are the major functions of M1 receptors? Mediation of higher cognitive functions and stimulation of enteric nervous system
Which Gp-second messenger is associated with ↓ in heart rate and contractility of the atria? M2
What are the major functions of M2 receptors? ↓ HR and contractility of the atria
What are some associated functions of M3 receptor agonism? ↑ Exocrine gland secretions (lacrimal, sweat, salivary, and gastric acid), bladder contraction, bronchoconstriction, miosis, ciliary muscle contraction (accommodation), insulin release, endothelium-mediated vasodilation.
What are the major functions of D1 receptors? Relaxes renal vascular smooth muscle, activates direct pathway of striatum
What are the major functions of D2 receptors? Modulates transmitter release, especially in brain, inhibits indirect pathway of striatum.
_____ activates _______ pathway of striatum D1; direct
_____ inhibits ________ pathway of striatum D2; indirect
What are the major functions of H1 receptors? ↑ nasal and bronchial mucus production, ↑ vascular permeability and vasodilation, bronchoconstriction, pruritus, and pain.
What are the major functions of H2 receptors? ↑ gastric acid secretion
What are the main functions of V1 receptors? ↑ vascular smooth muscle contraction
What are the main functions of V2 receptors? ↑ water permeability and reabsorption via upregulating aquaporin-2 in collecting tubules of the kidney, and ↑ release of vWF.
Which two G-protein second messengers ↑ vascular smooth muscle contractility? α1 and V1
Created by: rakomi
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