Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Hematology

New set 2023 UWORLD only

QuestionAnswer
What are the most common associations with Pure Red Cell Aplasia? Thymoma, lymphocytic leukemia, and parvovirus B19 infection.
How is Pure Red cell aplasia characterized clinically? Severe anemia w/ reticulocytopenia and morphologically NORMAL platelets and leukocytes.
What cancers are associated with BRCA gene germline mutation? Breast and Ovarian cancer
What leads to cancer in a BRCA gene mutation? Inability to repair ds-DNA breaks
To which anticancer medications are BRCA gene mutated cancers more susceptible? Platinum compounds
BRCA gene is responsible for: Repair ds-DNA breaks
How is the relationship of P50 in a Hb with HIGH affinity to oxygen? ↓↓ P-50
How is ↓P50 represented graphically in the oxygen-dissociation curve? Leftward shift
What are the results of ↓ability to release O2 w/in peripheral tissues? 1. Renal hypoxia 2. ↑ EPO synthesis 3. Compensatory erythrocytosis
MC Direct factor Xa inhibitor? Apixaban
What conversion is reduced by Direct factor Xa inhibitors? ↓↓ Prothrombin -----> Thrombin
Drug that actively blocks active site of factor Xa? Apixaban
↓↓ prothrombin ---> thrombin is caused by the use of what type of anticoagulants? Direct factor Xa inhibitors
What are the effects of aging in respect to new blood vessel synthesis? 1. ↑ Bone Marrow Fat 2. ↓ Bone Marrow mass 3. ↑ BM fat + ↓ BM mass ====> ↓↓ BM reserve
What type of anticoagulant is Enoxaparin? LMWH
What is a common LMWH? Enoxaparin
LMWH binds and activates which protein? Antithrombin III
Activated AT-III binds to what in order to initiate anticoagulation? Binds cofactor Xa ---> ↓ prothrombin to thrombin conversion
Do LMWHs act on factor Xa or thrombin? Factor Xa
Heparin acts directly on factor Xa or thrombin? Thrombin
What are 2 examples of Direct Oral factor Xa inhibitors? Rivaroxaban and Apixaban
What is an example of an Indirect factor Xa inhibitor? Fondaparinux
What is the main reason for preferred use of DOACs over Vitamin K antagonists (Warfarin)? Less variability in therapeutic drug effect
List of benefits of DOACs over VKAs: 1. Less variability in therapeutic drug effect with meds and diet 2. Do not require lab monitoring
What is the MC VKA? Warfarin
What is a common example of how cancer cells avoid immune recognition, leading to survival? Overexpression of PD-L1 on cancer cell
What is the role of PD-L1? Binding to PD-1 receptor on cytotoxic T cell --> inhibition of T cell response
What is "T-cell exhaustion"? Inability of cytotoxic T cell to respond to antigen due to overexpression of PD-L1 --PD-1 binding.
Why are monoclonal antibodies against PD-L1 and PD-1 effective against some particular cancers? Express elevated levels of NEOANTIGENS on its surface
The individual subunits of Hb molecule are structurally analogous (similar) to: Myoglobin
What labs are affected in the Early stage of Iron deficiency anemia? Loss of iron in storage = ↓↓ serum Ferritin
What labs are affected in the intermediate stage of iron deficiency anemia? ↓ serum Fe and transferrin saturation, due to Fe2+-limited erythropoiesis
What labs are added in decrement in the late stage of iron deficiency anemia? ↓↓ MCV, MCHC, Reticulocyte count
What are the 4 Ts (masses) associated with anterior mediastinum mass? 1. Thymoma 2. Teratoma (& germ cell tumors) 3. "terrible" lymphoma 4. Thyroid neoplasm
Which of the 4 Ts in anterior mediastinum masses is associated with elevated α-fetoprotein and ß-hCG levels? Non-seminomatous germ cell tumor
Amyloidosis is associated with which hematologic malignancy? Multiple Myeloma
What percentage level/range in a bone marrow sample of plasma cells is indicative of Multiple Myeloma? >10%
What causes Cyclic neutropenia? Mutation in the gene encoding NEUTROPHIL ELASTASE
What is the approximate time cycle of cyclic neutropenia? Every 3 weeks
What are common Bone Marrow findings of Cyclic neutropenia? Nuclear fragmentations and membrane blebbing
Created by: rakomi
Popular USMLE sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards