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Parvovírusok

Humán parvovírus B19

TermDefinition
fehérjéi (2) kics-, nagy kapszid (VP1, VP2)
nem-strukturális fehérje (2) NS1, 11kDA
NS1 jellemzői -ATP-áz, helikáz aktivitás -citotoxikus -permisszív, nem-permisszív sejtekbe -transzlokációja citokin termelést indukál -G2 fázisba állítja meg az erythroprogenitor sejteket
11kDa jellemzői (2) -apopotosist indukál -vírusreplikáció
target cells (3) -erythroprogenitor sejtek -leukocyták + -megakaryocyták + +nem szaporodik bennük
környezeti rezisztencia VAN
ilyenkor elterjedtebb tavasz, tél
lefolyása bekerül->gs.s. receptoron, P AG->S fázisú sejt citoplazmájába -> sejtmag->sd lánc alja feltekeredik ->primer celluláris DNS polimeráznak->ds át,emetileg ->+-sdDNS->mRNS->citoplazma->fehérjeszint.->citolysis->exit
betegségek -erythema infectiosum -CMP -encephalitis -non-immun-hydrops foetalis -purpurás kesztyő-zokni sy
szakaszok 1,2
1. szakasz -fertöző (légúton) -keringéssel erythroid elemekhez -nem spec. tünetek -10^12 kópia/ml -csökkent reticulocyta -leukopaenia -thrombocytopaenia -IgM 1.ként jelenik meg -nincs külső tünet
2. szakasz -nem fertőző!!! -IgM --> IgG (spec) -IC -IC lerakódik kis erekbe, ízületbe (szimm)
diagnosis -ránézel -endogén szintmérés
terápia -felnőttbe: NSAID -aplasztikus krízis- transzf.
Created by: Farmakodinámia
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