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Autoantibodies
Question | Answer |
---|---|
Antinuclear antibodies (ANA) | SLE |
Anti-dsDNA, anti-Smith | Specific for SLE (anti-Smith are most specific) |
Antihistone | Drug-induced lupus |
Anti-IgG | Rheumatoid arthritis (known as Rheumatoid factor) |
Anticentromere | Scleroderma (CREST) |
Anti-Scl-70 (anti-DNA topoisomerase I) | Scleroderma (diffuse) |
Antimitochondrial | Primary biliary cirrhosis |
Antigliadin, antiendomysial | Celiac Disease |
Anti-Basement membrane | Goodpasture's |
Anti-desmoglein | Phemigus vulgaris |
Antimicrosomal, antithyroglobulin | Hashimoto's thyroiditis |
Anti-Jo-1 | Polymyositis, dermatomyositis |
Anti-SS-A (anti-RO) | Sjogren's syndrome |
Anti-SS-B (anti-La) | Sjogren's syndrome |
Anti-U1 RNP (ribonucleoprotein) | Mixed connective tissue dz |
Anti-smooth muscle | Autoimmune hepatitis |
Anti-glutamate decarboxylase | Type I diabetes mellitus |
c-ANCA | Wegener's granulomatosis |
p-ANCA | Microscopic polyangitis (form of polyarteritis nodosa) |
The three vasculitides associated with antineutrophil cytoplasmic antibodies (ANCA) | Wegener's granulomatosis, Microscopic polyangitis, & Churg-Strauss syndrome |