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Ch.13
Drug-to-Food Interactions
Term | Definition |
---|---|
What are 3 ways that food affects how medications work in the body? | -Slow digestion -Alter the pH of the stomach -Change the bacterial flora of the intestines |
What does "take on an empty stomach" mean? | Take medications 2 hours after food was last ingested |
Why are antacids, PPI's, and H2 Agonists taken on an empty stomach? | Food is also an antacid so it will render the medication ineffective |
Why should fluoroquinolones not be taken with dairy products? | Dairy products can bind to the medication and make it ineffecticve |
Why are NSAID's usually taken with food? | Because they can irritate the stomach lining |
What happens when you take anticholinergic medications with alcohol? | Increased sedation |
What is the effect of having alcohol with disulfiram? | Severe nausea and vomiting due to decreased ability to digest alcohol |
What are medications with similar effects as disulfiram when taken with alcohol? | -Cephalosporins -Chloral hydrate -Metronidazole |
Why should patients limit alcohol consumption when taking tylenol? | Increased risk of liver damage |
What about grapefruit juice makes it interact with so many medications? | It's a CYP450 inhibitor so it increases the level of medication metabolized by CYP450 |