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psychopharmacology
Neuropharmacology, S1KW
Question | Answer |
---|---|
Effective Dose (ED) | % of people for whom a particular dose will cause the desired effects. (If ED50 for Fluoxetine is 150mg, 50% of population will be effected.) |
Lethal Dose (LD) | % of fatalities at a drug dose. |
Safety Margin | Difference between ED50 and LD1 |
Potency | The strength of binding between a drug (ligand) and the target (receptor). |
Efficacy | The biological effect exerted by the binding. |
Bioavailability | This is how well the drug gets into the brain and to its site of action. |
Agonist | Drug binds to receptor and mimics the neurotransmitter. |
Antagonist | Drug binds to receptor but produces no biologic effect. |
Inverse Agonist | Produces an effect which is opposite the effect of the agonist. |
Saturability | Saturation occurs when all receptors are occupied. |
Selectivity | Receptors are selective for specific drugs. |
Reversability | Binding is usually reversible. |
Synapse | Space between bouton and receptor site. |
Mitochondria | Essentially the energy source of a neuron. |
Blood-Brain Barrier | A protective network of blood vessels and cells that filters blood flowing to the brain. |
Depolarization | Pushing membrane toward 0. |
Hyperpolarization | Pushing membrane away from 0. |
Transmembrane Potential | -70 mV (-70 x 100 billion neurons). Maintained by active processes such as membrane ion pumps. |
Transduction | translating one form of energy into another |
Exocytosis | When vesicles which contain neurotransmitters go to the surface of the membrane and release into the synapse. |
Synapse | must have vesicles and membrane thickening |
Microglia | (Glial cell) tiny, move through brain easily, perform phagocytosis |
Phagocytosis | eating of dead tissue |
Nodes of Ranvier | The gaps formed between myelin sheath cells along the axons. |
Myelin | fatty sheaths that coat axons to promote faster conduction. |
Temporal Summation | Administering another stimulus before the action potential of previous stimulus begins to recede. |