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WVSOM Phys Body H2O
WVSOM, Physiology, Dr. Hamra, 2011
Question | Answer |
---|---|
Extracellular Water | 20% of Body Weight Interstitial Water + Plasma Water 14 Liters |
Interstitial Water | 15% of Body Weight 10.5 Liters |
Intacellular Water | 49% of Body Weight 28 Liters |
Plasma Water | 5% of Body Weight 3.5 Liters |
Blood Volume | Total Blood Volume = 5.5 Liters The plasma portion = 3 to 3.5 Liters The remainder=RBCs, WBCs,and Platelets |
Formula for Concentration | Concentration=Mass/Volume |
Formula for Volume | Volume=Mass/Concentration |
Formula for Volume Distribution | Volume Distribution= (Mass Injected-Mass Lost)/Plasma Concentration |
Name 3 indicators for Total Body Water | 1. Antipyrine 2. Heavy Water D2O 3.Tritiated Water (DTO) |
Name 2 indicators for Plasma Water | 1. Evans Blue 2. Iodinated Albumin |
Formula for Intracellular Fluid Volume | Intracellular Fluid Volume=Total Body Water-Extracellular Water |
Name the indicators for Extracellular Water | Impermeate Ions=radioactive Na+,Cl-,Sulfate, SO4--,Thiocyanate,Thiosulfate Inert Sugars=inulin,mannitol,sucrose |
Formula for interstitial water volume | Interstitial water volume=Extracellular Water-Plasma Water |
Formula for Total Body Water | Total Body Water=Intracellular water=Extracellular Water |
Formula for Extracllular Water | Extracellular Water=Interstitial Water+Plasma Water |
Define Osmolality | Osmolality=the number of osmotically active particles in a solution |
Name the principle electrolyte in the intracellular compartment | K+ at 120mM |
Name the principle electrolyte in the extracellular compartment | Na+ at 142mM |
What is the osmolality of an isotonic/isoosmolal solution? | 290mOsm |
What is the osmolality of a hypertonic/hyperosomolal solution? | >290mOsm |
What is the osmolality of a hypotonic/hyperosmolal solution? | <290mOsm |
By convention, the terms "Volume Expansion" and "Volume Contraction" always refer to ___________________? | Extracellular Water |
A 145mM NaCl solution is considered isotonic because __________________? | 145mM NaCl solution contributes two (Na+ and Cl-)osmotically active particles. 145Na+ + 145Cl-= 290 |
True or False, Na+ freely crosses the cell membrane. | False, this is why hyperosmotic volume expansion of the extracellular space occurs. |
Diarrhea results in _____-osmotic volume __________? | Iso-osmotic Volume Contraction |
Infusion of Isotonic NaCl results in ____-osmotic volume _________? | Iso-osmotic Volume Expansion |
High NaCl intake results in___-osmotic volume_________? | Hyperosmotic Volume Expansion |
Water Deprivation results in ____-osmotic volume___________? | Hyperosmotic Volume Contraction |
Adrenal Insufficiency (not enough aldosterone, causing loss of Na+ and water, but more Na=than water) results in ___-osmotic volume______? | Hyperosmotic Volume Contraction |
Fever, Sweating, and Diabetes Incipidus (too little ADH) results in ____-osmotice volume __________? | Hyperosmotic Volume Contraction |
Protein Concentration increases or decreases with volume contraction? | Increases |
Protein Concentration increases or decreases with volume expansion? | Decreases |
Syndrome of Inappropriate ADH (AKA:SIASH)causing too much ADH results in ___-osmotic volume_____? | Hypoosmotic Volume expansion |
What is the body's short term adjustment mechanism to blood pressure changes? | Modulation of the autonomic nervous system output to heart and blood vessels |
What are the body's intermediate and long-term adjustment mechanisms to blood pressure changes? | Regulation of whole-body Na+ content via the kidneys. |
The body's four response systems work to increase or decrease Na+ excretion in response to greater blood volume? | Increase Excretion |
Increased osmolality results in _______ secretion of ADH, and ______ thirst? | Increased ADH secretion, and increased thirst. |
Low blood volume causes increased or decreased RAAS activity? | Increased RAAS Activity |
Low blood volume causes increased or decreased sympathetic outflow? | Increased Sympathetic Outflow |
Low blood volume causes increased or decreased Arginine, Vasopressin, and ADH secretion? | Increased secretion |
Low blood volume causes increased or decreased Arial Natriuretic Peptide secretion? | Decreased ANP, which stops the dumping of Na+ into the urine. |