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DIT 2009 WK 12
Q&A from DIT emailed questions WK 12
| Question | Answer |
|---|---|
| Clinical findings in pt with lead poisoning | Encephalopathy and erythrocyte basophilic stippling, abdominal colic, constipation, headaches, peripheral neuropathy (wrist/foot drop), sideroblastic anemia (mycrocytic, hypochromic) |
| Anticancer agent who's toxicity is increased by allopurinol | 6-mercaptopurine |
| Anticancer agent that is cardiotoxic | Doxorubicin (Adriamycin) and Daunorubicin |
| Anticancer agent that blocks polymerization of tubulin | Vincristine and Vinblastine |
| Anticancer agent known to cause hemorragic cystitis | Cyclophosphamide and Ifosfamide |
| Anticancer agent that crosses the blood-brain barrier (used for brain cancerrs) | Nitrosureas |
| Side effects of Clonidine | Dry mouth, sedation, severe rebound hypertension |
| Artery most often the culprit in an MI | LAD > RCA > Circumflex |
| What is Exstrophy of the bladder | Congenital gap in anterior bladder wall and abdominal wall in front of it – exposure of bladder inferior to outside world |
| Condition normally associated with exstrophy of the bladder | Epispadias |
| Serotonin agonist used to treat migraine headaches | Sumatriptan |
| Clinical uses of Ondansetron | Control vomiting postoperatively and in pts undergoing cancer chemotherapy |
| What is Syringomyelia | Enlargement of the central canal of the spinal cord. MC at C8-T1 |
| Common symptoms seen in Syringomyelia | Bilateral loss of pain and temperature sensation in upper extremities with preservation of touch sensation |
| Abnormality a/w with calf pseudohypertrophy | Duchenne's |
| Abnormality a/w with Gower's maneuver | Duchenne's |
| Abnormality a/w with tendon xanthomas | Familial Hypercholesterolemia |
| Abnormality a/w with subluxation of the lenses | Marfan's |
| Abnormality a/w with cafe-au-lait spots | Alport's |
| Abnormality a/w with tuft of hair on lower back | Neural tube defect - spina bifida occulta |
| Typical presentation of a pt with Hodgkin's disease | Constitutional "B" signs/symptoms - low grade fever, night sweats, weight loss |
| Cancers a/w xeroderma pigmentosa | Melanoma, basal cell carcinoma, and especially Squamous cell Carcinomas of skin |
| Cell types that do not require insulin for the uptake of glucose | Brain and RBC's |
| Typical presentation of a pt with pancreatic insufficiency | Malabsorption of fat and fat-soluble vitamins |
| Treatment for pancreatic insufficiency | Limit fat intake, replace fat-sol vitamins, or ingest oral pancreatic lipase |
| Why is the murmur of Ao stenosis not heard during the first part of systole | B/c the pressure still isn't large enough to open the stenotic valve |
| Potential metabolic fates of pyruvate | Alanine, Oxaloacetate, Acetyl-CoA, Lactate, and Alcohol |
| Physical changes taking place during REM sleep | Increase and variable pulse, penile/clitoral tumescence, variable blood pressures |
| Nerve that innervates the "glossus" muscles | Hypoglossal Ne |
| Nerve that innervates the "palat" muscles | Vagus Ne |
| Types of cancer/s are associated with chromosomal translocation (9;22) | CML (bcr-abl hybrid) |
| Types of cancer/s are associated with chromosomal translocation (8;14) | Burkitt's lymphoma (c-myc activation) |
| Types of cancer/s are associated with chromosomal translocation (14;18) | Follicular lymphoma (bcl-2 activation) |
| Types of cancer/s are associated with chromosomal translocation (15;17) | M3 type of AML (responsive to all-trans retinoic acid) |
| Types of cancer/s are associated with chromosomal translocation (11;22) | Ewing's sarcoma |
| Types of cancer/s are associated with chromosomal translocation (11;14) | Mantle cell lymphoma |
| Cell type that produces PTH | Chief cells of Parthyroid |
| Cell type that produces calcitonin | Parafollicular cells (C cells) of thyroid |
| Explain the Renin-Angiotnesin-Aldosterone pathway | Renin stimulates conversion of Angiotensinogen to angiotensin I which is converted to angiotensin II by ACE. Angio II then stimulates aldosterone production from adrenal cortex (amongst other things) |
| Part of the cochlea sensitive to High-Frequency sounds | Base of cochlea, near oval and round windows |
| Name the vitamin K clotting factors | 2, 7, 9, 10, and protein C and S |
| Drug that antagonizes with Vitamin K | Warfarin |
| Why is heparin given concurrently as Warfarin is initiated | Heparin has a faster onset of action, while Warfarin takes time to have an effect, so while warfarin takes effect, one gives Heparin |
Created by:
snezya24
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