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Nov 18 Notes
Addictionology
Question | Answer |
---|---|
Stimulant Effects | Sweating, increased heartbeat, dilation of pupils, increased body temperature, increased BP, “RUSH”:(feeling of euphoria and powerfulness) |
Stimulant problems | Respiratory problems.Damaged nasal and bronchial passages. |
Cardiovascular stimulant problems | Increased heart diseases b/c the first place a drug goes to the heart b/c of the blood vessels carry the drugs. |
Liver stimulant problems | Damage to liver from metabolizing the drug. |
CNS | Cocaine is a vasoconstrictor (narrowing of blood vessels)Strokes are a common result. b/c you are not getting the needed blood to the areas. |
Freud | used cocaine in his research, diluted the value of his research. Proved human beings have a 24 hour cycle in a day. Very embarrassed about his use of it. Thought of it as cure for depression, and cure for opiate addiction. |
1800-1900’s Cocaine | was thought of as a mild vice. |
Hx of Cocaine & Coca Cola | did Coke have cocaine in it? YES. 1906 Pure FDA De-cocained the leaves |
Nuero T’s and Cocaine | massive release of Dopamine AND blocks reabsorption, meaning makes it so the brain can’t “suck” it back up into the synaptic gap. |
Cocaine fun-fact | Cocaine can “autometabolize” after death. That means it will continue to reduce in potency in the blood even if someone has died. Little enzymes like to eat it up. |
Amphetamines | first isolated in 1887. Benzedrine (Bennys) were considered a safe alternative to cocaine. |
Transition of amphetamines to METH amphetamines | synthesized in 1893 in Japan. METH makes it longer lasting, BUT speeds the absorption and potency. |
METH | MORE POTENT and MORE RAPIDLY ABSORBED |
NICOTINE | is a stimulant, with some depressant EFFECTS. |
NICOTINE | After WWI, were distributed to the troops with their meals. |
Nicotine use increased | By 1960, 52% of males, 32% used tobacco. |
Nicotine in 1990 | more 6 yr olds could recognize Joe Camel than Mickey Mouse. |
Nicotine and content | Legally proven in court, tobacco manipulate the nicotine content, THE POTENCY, in cigarette’s to KEEP the smoker ADDICTED. |
Nicotine PharmacologyCNS Stimulant or depressant in the short term? | it's a stimulants b/c increases heart rate and B/P but...a depressant:Vasodialation and dopamine release will often lower the HR and B/P. |
Nicotine short term vs long term use | |
Nicotine Lethal Dose | 60 mg. 1 cig=10mg. |
Nicotine and Chemicals | There are hundreds of active chemicals in tobacco, there are thousands of chemicals in tobacco after you light it on fire. |
Nicotine and cancer | Nicotine causes cancer. |
Nicotine and withdrawal symptoms | A large part of the positive relaxation part of a cigarette is a reduction in acute withdrawal symptoms. |
1923 Lung cx | was NOT listed as a disease. Were not aware this happened |
behavioral component of smoking | When something has a behavioral component, society feels ppl bring it on themselves, let them deal with it. |
Hallucinogens | actually a misnomer (named incorrectly) some hallucinogen (something that is not there) users see hallucinations, typically they experience delusions |
Hallucination | perception in the absence of stimulus |
Delusion | Misinterpretation of reality, an existing stimulant. |
Hallucinogens | Effects rely heavy on the setting.Cz’s random firing in the brain. Subjective feeling to the significance of the events. |
(HPPD)Hallucinogen Persisting Perception Disorder | effect of a return of some of the symptoms of hallucinogen intoxication. Better known as “flashbacks”. |
(HPPD) Common forms | tracers and general feeling that something is not right. |
Other Hallucinogens | Mescaline, found in Peyote. Psilocybin: active ingredient in mushrooms. Nutmeg - vomits for an hour, then small amount of hallucination. |
Inhalant’s | class of drugs see a spike at 8th grade b/c it is easily available in home and cheap. |
Inhalant’s administration | Snorting/sniffing, bagging-limits the oxygen and concentrates the substance, huffing, spraying directly into the nose and mouth |
Inhalants: the Common substances abused | DANGEROUS!DANGEROUS!DANGEROUS! Toluene: one of the most abused solvents. Higher level of toluene,the better the high. |
Anoxia | lack of oxygen to the brain. Is caused by inhaled and by the bonding effect to the lung tissue. |
Anabolic Steroids | Increase testosterone. Increases muscle mass and decreases the time for healing |
Androgenic Steroids | increase or mimic male hormones for a variety of goals. |
Common types of steroid use | Mega dosing-takes large dose Cycling-multiple doses over time with periods of abstinence to reduce the tolerance Stacking-more than one type at a time Array-taking other medications in conjunction to combat the side effects |
Steroid abuse symptoms | embalancing testosterone cz's physical aspects to change: men get breast, penis shrink's, voice changes, women get harrier, clitoris enlarges, |
symptoms | Swelling of feet or lower limbs. foul smelling breath, changes in skin, acne. Increase or decrease in body hair, male-pattern baldness, shrinkage of testi's, atrophy of penis in males, Enlargement of male breasts, breast reduction in females. enlargement |
symptoms continued: enlargement of external genitalia in females. Depression. Restlessness. Loss of appetite. Diminished sex drive HA Insomnia. |