| Question | Answer |
| Ampicillin/Sulbactam (Unasyn) | Penicillins, bactericidal, weaken cell wall, strep pneumonia, meningitis, endocarditis. |
| Erythromycin | macrolides, can be both bactericidal and bacteriostatic,inhibit protein synthesis. strep infection, upper respiratory infection, Spirochetes and STD's. |
| Cefotetan (Cefotan) | Cephalosporin 2nd generation, bactericidal, weaken cell wall, surgical prophylaxis (1st Generation used more often). Less sensitive to destruction by beta-lactamases (cephalosporinases) better activity against gram - than 1st generation, |
| Linezolid (Zyvox) | Oxazolidinones. Inhibits protein synthesis. VRE and MRSA (limiting to those will help delay emergence of resistance) |
| Amikacin | Aminoglycosides, bactericidal, inhibits protein synthesis. psuedomonas and E-coli. |
| Doxycycline | Tetracycline, bacteriostatic, inhibit protein synthesis. Lyme's disease, Rickettsia, syphilis. |
| Dalfopristin/Quinupristin | Combination Antibiotic. Streptogramins. Inhibit protein synthesis. (used separately are bacteriostatic - used together like this and they become bactericidal). Used for VRE. ***Hepatotoxicity is a BIG CONCERN. |
| ketolide (telethromycin) | ketolides, bateriostatic and can be bactericidal, inhibit protein synthesis. Mild to moderate upper respiratory infections. |
| Piperacillin/tazobactam(Zosyn) | Penicillins, bactericidal, weaken cell wall, strep pneumonia, meningitis, endocarditis. |
| Penicillin G | Penicillins, bactericidal, weaken cell wall, strep pneumonia, meningitis, endocarditis. |
| Chloramphenicol (chloromycetin) | Primarily bacteriostatic (can also be bactericidal against specific bugs). Used judiciously when other antibiotics don't work. Often used with other abx. Penicillin resistant bacterial meningitis and VRE.
Gray's syndrome in infants and children. |
| Gentamycin | Aminoglycosides, bactericidal, inhibits protein synthesis. psuedomonas and E-coli. |
| Fosfomycin (Monurol) | Bactericidal, weakens cell wall, single dose therapy for uncomplicated UTI in women. |
| Ceftriaxone (Rocephin) | 3rd Generation Cephalosporin, more active against gram - bacteria than 1st or 2nd generation. Clinically effective concentrations in CSF. Drug of choice for some specific meningitis. Highly resistant to beta lactamases. |
| Nafcillin | Penicillins, bactericidal, weaken cell wall, strep pneumonia, meningitis, endocarditis. |
| Sulfamethoxazole/Trimethoprim (SMZ/TMP) | Sulfonamide combo, bacteriostatic, UTI and otitis media |
| Aztreonam (Azactam) | Monobactam, bacteriocidal, inhibits protein synthesis. Only active against gram negative (E Coli, Klebsiella, etc) |
| ketolide (telethromycin) | ketolides, bateriostatic and can be bactericidal, inhibit protein synthesis. Mild to moderate upper respiratory infections. |
| Ticacillin/clavulanic acid (Timentin) | Penicillins, bactericidal, weaken cell wall, strep pneumonia, meningitis, endocarditis. |
| Monoxycarbolic Acid (mupirocin) | Bacteriostatic at low concentrations and bacteriostatic at high concentrations. Used topically, effective against gram positive bacteria. Treats impetigo. |
| Cefepime (Maxipime) | Cephalosporin 4th generation, bactericidal, weaken cell wall, CSF infection. Highly resistant to destruction by beta-lactamases (cephalosporinases).Healthcare and hospital associated pneumonias. |
| Tigecycline | Glycylcycline, glycycline (derivative of tetracycline class),bacteriostatic, inhibits protein synthesis.designed to overcome drug-resistance, broad spectrum including many drug resistant strains BUT is associated with increased mortality. |
| Metronidazole (Flagyl) | Flagyl, bactericidal. C-difficile, H-pylori. Watch for CNS effects. |
| Azithromycin | aka "Z-pack" erythromycin (macrolides), can be both bactericidal and bacteriostatic,inhibit protein synthesis. Acute bronchitis, pneumonia, & pink eye. |
| Oxacillin | Penicillins, bactericidal, weaken cell wall, strep pneumonia, meningitis, endocarditis. |
| Clindamycin (cleocin) | Bacteriostatic. Respiratory tract infections, skin and soft tissue infections, and peritonitis. |
| Pleuromutilin | Inhibits protein synthesis. Currently topical application and is highly resistant to becoming drug resistant. (long hx in vet medicine without resistance) |
| Cefazolin (Ancef) | Cephalosporin 1st generation, bactericidal, weaken cell wall, surgical prophylaxis. Destroyed by beta-lactamases (cephalosporinases) |
| Imipenem (Primaxin) | Carbapenems, bactericidal, weaken cell wall. Bone, joint, skin, and soft tissue (complicated body cavity infections). |
| Tobramycin | Aminoglycosides, bactericidal, inhibits protein synthesis. psuedomonas and E-coli. |
| Levofloxacin (Levaquin) | Fluoroquinolones, inhibit bacterial synthesis of DNA and RNA or disrupt DNA function. Pneumonia, Kidney infection, prostatitis. Watch for CNS |
| Vancomycin | Vancomycin, bactericidal, cell wall destroyed, MRSA and pts with penicillin allergies. ***Watch for renal damage. |
| Amoxicillin/clavulanate (Augmentin) | Penicillins, bactericidal, weaken cell wall, strep pneumonia, meningitis, endocarditis. |
| Rifampin (Rifacin) | Bactericidal, inhibits bacterial synthesis of DNA and RNA or disrupts RNA function. Tuberculosis |
| Clarithromycin | erythromycin (macrolides), can be both bactericidal and bacteriostatic,inhibit protein synthesis. Strep throat & pneumonia. |
| ***5th generation Cephalosporin | Similar to 3rd generation but has "activity" against MRSA - unlike generations 1-4 that cannot be used to treat MRSA. Highly resistant to destruction by beta-lactamases (cephalosporinases) |
| Sulfamethoxazole | Sulfonamides, bacteriostatic, antimetabolite, UTI and Nocardiosis. |
| Daptomycin | Cyclic lipopeptides. Bactericidal. Nearly all gram + bacteria including MRSA. |
| Ciprofloxacin (Cipro) | Flouroquinolones, inhibit bacterial synthesis of DNA and RNA or disrupt DNA function. Cellulitis, kidney infection, UTI, and Anthrax. |
