Hematology
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| show | No, do not lay down for 1 hour.
🗑
|
||||
| show | Full glass of water,
🗑
|
||||
| show | 2months
🗑
|
||||
| show | Absorption decreases
🗑
|
||||
| show | When there’s a large deficit, when oral absorption is decreased, when pt simply doesn’t want to
🗑
|
||||
| show | Consider weight of pt, calculate Fe deficit, and do a test dose
🗑
|
||||
| 7. What is the relationship between alcoholics and Folic acid? | show 🗑
|
||||
| 8. How does the use of antibiotics affect folic acid deficiency? | show 🗑
|
||||
| show | Yes, after a meal a person may appear to have enough folic acid, may not seem like Folic acid anemic
🗑
|
||||
| 10. Where do people get their B12? | show 🗑
|
||||
| 11. How are B12 found in the system? | show 🗑
|
||||
| 12. Where is B12 absorbed? | show 🗑
|
||||
| 13. What interferes with B12 absorption? | show 🗑
|
||||
| show |
🗑
|
||||
| 15. What produces EPO? | show 🗑
|
||||
| 16. What increases EPO? | show 🗑
|
||||
| show | A modified version of EPO which has an increased half life
🗑
|
||||
| 18. What type of patients should be put on Darbepoetin? | show 🗑
|
||||
| show |
🗑
|
||||
| show | Increased bp
🗑
|
||||
| show | EPO
🗑
|
||||
| show | GI, nausea, vomiting, and HTN
🗑
|
||||
| show | Body’s normal process of preventing bleeding
🗑
|
||||
| 24. What is the first degree hemostasis? | show 🗑
|
||||
| show | Clotting plasma, fibrin deposition
🗑
|
||||
| show |
🗑
|
||||
| 26. What is vit K required for? | show 🗑
|
||||
| 27. What causes K deficiency? | show 🗑
|
||||
| show | Bleeding or asymptomatic pts with a prolonged PT
🗑
|
||||
| 29. What is K treatment? | show 🗑
|
||||
| 30. What is factor 8 bound to in circulation? Bound to vWF while inactive in circulation | show 🗑
|
||||
| show | Degrades rapidly
🗑
|
||||
| show | Thrombin
🗑
|
||||
| show | Exposed collagen binds to vWF
🗑
|
||||
| 34. What is the most common type of Hemophilia? | show 🗑
|
||||
| show | Inherited disorder of protein required to form blood clot is missing or reduced
🗑
|
||||
| 36. Can spontaneous gene mutation cause hemophila A? | show 🗑
|
||||
| show | Problems with bleeding only after serious injury or trauma or surgery
🗑
|
||||
| 38. What is moderate hemophilia A? | show 🗑
|
||||
| show | Bleeding following an injury and may have frequent spontaneous bleeding episodes, often into the joints and muscles.
🗑
|
||||
| 40. What happens in vWF deficiency or dysfunction? | show 🗑
|
||||
| 41. How is hemophilia A managed? | show 🗑
|
||||
| 42. How is factor 8 levels increase? | show 🗑
|
||||
| 43. How is hemostasis restored in hemophiliacs? | show 🗑
|
||||
| 44. When is home therapy of F8 allowed? | show 🗑
|
||||
| 45. How is life threatening bleeds treated? | show 🗑
|
||||
| show | With 100 units/kg IV bolus human F8 followed by infusion of 10units/kg/hr
🗑
|
||||
| 47. What was the problem of plasma transfusion in early days? | show 🗑
|
||||
| 48. What was the role in pharmaceutical companies in reducing transmission of diseases when blood transfusion took place? | show 🗑
|
||||
| show | Antibody formation
🗑
|
||||
| 50. What is it dependent on? | show 🗑
|
||||
| 51. What are anticoagulants? | show 🗑
|
||||
| 52. Do anticoagulants dissolve existing clots? | show 🗑
|
||||
| show | Naturally occurring polysaccharide that inhibits coagulation
🗑
|
||||
| show | Varying molecular chains of varying lengths and molecular weights
🗑
|
||||
| show | porcine or bovine intestinal mucosa.
🗑
|
||||
| 56. What is MOA for heparin? | show 🗑
|
||||
| 57. What are the benefits of giving heparin parenterally? | show 🗑
|
||||
| show | Delayed effect and prolonged effect
🗑
|
||||
| show | Must be monitored daily and dose adjusted to the target therapeutic range due to the 10 fold intersubject variability in response to a given dose of heparin
🗑
|
||||
| 60. What is antithrombin? | show 🗑
|
||||
| show | Its adhesion to thrombin factors increased in the presence of heparins
🗑
|
||||
| show | Yes
🗑
|
||||
| show | Antithrombin 3 which inactivated thrombin
🗑
|
||||
| show | Converts fibrinogen to fibrin
🗑
|
||||
| show | Conversion of fibrinogen to fibrin form fibrin clots
🗑
|
||||
| show | Heparin
🗑
|
||||
| 67. Why are pregnant pts able to take heparin? | show 🗑
|
||||
| 68. What are the ADRs of heparin? | show 🗑
|
||||
| 69. What is aPTT? | show 🗑
|
||||
| show | Blood is collected with oxalate or citrate to prevent coagulation, specimen is delivered to the lab. Activator (such as silica, celite, kaolin, ellagic acid) is added to activate intrinsic pathway and calcium is added to reverse the effect of oxalate. The
🗑
|
||||
| 71. When heparin is administered what signs be monitored? | show 🗑
|
||||
| 72. What is administered in heparin over dose? | show 🗑
|
||||
| 73. What are the indications for heparin? | show 🗑
|
||||
| show | Do not administer to pts with bleeding disorders, PUD, recent eye, brain, spinal surgery, sever liver/renal disease, hemophilia
🗑
|
||||
| show | Yes, SC is 20-60 mins
🗑
|
||||
| 76. When is heparin clearance prolonged? | show 🗑
|
||||
| 77. What is the standard dosage and high risk pt dosage? | show 🗑
|
||||
| show | Bleeding, concomitant antiplatelet use result in increased risk of bleeding - therefore avoid, GI bleeding is contraindication for heparin therapy, osteoporosis result in long term therapy
🗑
|
||||
| show | To reverse heparin effects or overdose of heparin
🗑
|
||||
| 80. What are the considerations when using protamine sulfate? | show 🗑
|
||||
| show | Protamine sulfate
🗑
|
||||
| show | Only short chain polysaccharide
🗑
|
||||
| 83. What is a property of LMWH? | show 🗑
|
||||
| 84. How are LMWH obtained? | show 🗑
|
||||
| show | Dalteparin, Enoxaparin, Ardeparin
🗑
|
||||
| 86. What is Enoxaparin? | show 🗑
|
||||
| show | Arterial thrombosis, venous thromboembolism, thrombophlebitis, DVT, calf vein thrombosis, DVT prophylaxis
🗑
|
||||
| 88. What are the advantages of having LMWH as opposed to unfractionated? | show 🗑
|
||||
| show | Limited reversibility
🗑
|
||||
| show | Less effect
🗑
|
||||
| show | Same as heparin
🗑
|
||||
| show | Inhibit liver synthesis of Vitamin K, the depending clotting factors are 2,7,9,10
🗑
|
||||
| show | Prevent clotting in thrombophlebitis, PE and embolism related to AFib
🗑
|
||||
| 94. What are the contraindications of oral anticoagulants? | show 🗑
|
||||
| show | Prolongs clotting time and adjusted upward or downward accordingly
🗑
|
||||
| show | Another name for Coumadin, with onset of 2-7 days and half life of .5-3 days
🗑
|
||||
| show | Inhibits vitamin K conversion to active form and will lead to depletion of clotting factors 2,7,9,10
🗑
|
||||
| 98. Is it well absorbed orally? | show 🗑
|
||||
| show | Foods high vitamin K
🗑
|
||||
| show |
🗑
|
||||
| 101. What are complications of warfarin? | show 🗑
|
||||
| show | Vitamin K
🗑
|
||||
| 103. What is the warfarin indications for nursing and pregnant pts? | show 🗑
|
||||
| 104. What needs to be monitored for oral anticoagulants? | show 🗑
|
||||
| 105. What is recombinant hirudin? | show 🗑
|
||||
| 106. How do you monitor Lepirudin? | show 🗑
|
||||
| 107. What should be considered when treating Lepirudin? | show 🗑
|
||||
| show | TBXA2 and ADP
🗑
|
||||
| show | For further recruitment of platelets as wells as the amplification of activation signals as described above. The secreted agonists activate their respective G protein coupled receptors. This interaction counteracts the stimulation of cAMP formation by end
🗑
|
||||
| show | Platelet adhesion, cytoskeletal reorganization, degranulation, and amplification loops
🗑
|
||||
| 111. What results in platelet plug formation cascade? | show 🗑
|
||||
| show | Linkage of activated platelets through fibrinogen leads to aggregation
🗑
|
||||
| 113. What happens when the Fibrinogen receptor is inhibited? | show 🗑
|
||||
| show | Decrease formation or the action of chemical signals that promote platelet aggregation
🗑
|
||||
| show | Aspirin, ticlopidine, dipyridamole, clopidogrel, sulfinpyrazone
🗑
|
||||
| 116. What are some glycoprotein receptor antagonists? | show 🗑
|
||||
| show | Prevention and treatment of occlusive cardiovascular disease, maintenance of vascular grafts and arterial patency
🗑
|
||||
| 118. What is sulfinpyrazone? | show 🗑
|
||||
| show | It is the mainstay of primary and secondary heart disease prevention, is an irreversible inhibitor of platelet cyclooxygenase and platelet thromboxane A2 production
🗑
|
||||
| 120. What type of platelet aggregation is not prevented by aspirin? | show 🗑
|
||||
| show | 5% resistance, 25% partial response
🗑
|
||||
| 122. What is clopidogrel? | show 🗑
|
||||
| 123. How do ticlopidine and clopidogrel block ADP induced platelet activation? | show 🗑
|
||||
| 124. What is Abciximab? | show 🗑
|
||||
| show | It inhibits platelet aggregation by specifically binding to the glycoproteins GP2b/3a receptor, the major surface receptor involved in the final common pathway for platelet aggregation
🗑
|
||||
| show | Fibrinogen, von Willebrand factor, vitronectin, and other adhesive molecules from binding to the receptor.
🗑
|
||||
| show | As an adjunct to aspirin and heparin for the prevention of acute cardiac ischemic complications not responding to conventional medical therapy or when percutaneous coronary intervention is planned w/in 24hrs
🗑
|
||||
| show | Human anti chimeric antibody (HACA) development may occur secondary to abciximab therapy. HACA titers may have allergic or hypersensitivity rxns when treated with other diagnostic or therapeutic monoclonal antibodies, include bleeding, orthostatic hypoten
🗑
|
||||
| 129. How does tirofiban inhibits platelet aggregation? | show 🗑
|
||||
| 130. What is tirofiban indicated for? | show 🗑
|
||||
| 131. What is eptifibatide indicated for? | show 🗑
|
||||
| 132. What is ADR for eptifibatide? | show 🗑
|
||||
| 133. What is MOA for eptifibatide? | show 🗑
|
||||
| 134. What is MOA of aspirin? | show 🗑
|
||||
| show | Prophylactic treatment of transiet cerebral ischemia
🗑
|
||||
| show | Prolongs bleedings times, may cause additional complications
🗑
|
||||
| show | Inhibits platelet aggregation through decreasing the binding of platelets to fibrinogen and to each other, reduce incidence of thrmbotic stroke. What is an ADR?
🗑
|
||||
| show | Ticlopidine is more effective than aspirin in preventing initial stroke in pts with stoke precursors, but causes significantly more ADR than asprin.
🗑
|
||||
| show | Neutropenia, agranulcytosis, aplastic anemia and thrombotic thrombocytopenic purpura. Reserved for pts unable to take aspirin or who develop strokes despite aspirin therapy, and only when close hematologic monitoring is possible
🗑
|
||||
| show | Inhibits ADP induced binding of fibrinogen to GP2b/3a complex, inhibits release of platelet granule constituents, platelet platelet interactions, and platelet adehesion to the endothelium and to atheromatous plaque.
🗑
|
||||
| show | Coronary vasodilator, prophylaxis against angina pectoris usually given with combination with aspirin
🗑
|
||||
| show | Inhibits thromboxane A2, synthesis and may decrease platelet adhesion through potentiation of prostacyclin PG12
🗑
|
||||
| 143. What dipyridamine is given in combination? | show 🗑
|
||||
| show | Reducing the risk of atherosclerotic events (MI, stroke, and vascular death) in patients with atherosclerosis documented by recent MI, recent stroke, or established peripheral arterial disease
🗑
|
||||
| show | Inhibits ADP binding to its platelet receptor and activation of the glycoprotein GP2b/3a, because clopidogrel irreversibly modifies the ADP receptor, platelets are affected for the remainder of their life span. Platelet aggregation induced by agonists oth
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
sap_213
Popular Pharmacology sets