Duke PA GI Pharmacology
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| show | acid and pepsin
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| show | acetylcholine, histamine, gastrin
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| pretective forces in GI | show 🗑
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| Helicobacter pylori produces __ which forms an acid-neutralizing cloud that protects H. pylori but damages tissue | show 🗑
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| show | H. pylori
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| NSAID mechanism of injury to stomach | show 🗑
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| show | food worsens pain
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| show | pain relieved by food/antacids
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| show | DU
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| most __ are biopsied to r/o cancer | show 🗑
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| by neutralizing acid __ is inhibitied | show 🗑
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| show | antacids
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| onset of antacids is usually __ after administration | show 🗑
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| duration of antacids is usually __ | show 🗑
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| show | aluminum hydroxide, magnesium hydroxide, calcium carbonate
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| systemic antacids | show 🗑
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| show | constipation
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| show | diarrhea
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| show | constipation
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| can deliver large amounts of sodium to systemic circulation, can alter systemic pH, use only for short term | show 🗑
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| show | parietal cells
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| properly taken H2A will heal __% of DU at 8 weeks and __% of GU at 12 weeks | show 🗑
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| __ can cause alcohol to remain in your system for longer | show 🗑
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| block gastric acid secretion by inhibiting gastric H/K ATPase in gastric parietal cells | show 🗑
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| produces profound, long lasting anti secretory effects | show 🗑
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| show | Sucralfate (carafate)
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| a synthetic prostaglandin that increases mucus production and mucosal bicarb. Indicated for NSAID induced gastric ulcers. | show 🗑
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| show | Diarrhea, ab pain, flatulence, abortifacient
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| retrograde movement of gastric contents from the stomach into the esophagus | show 🗑
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| drugs that decrease gastric acid | show 🗑
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| show | bethanechol, metoclopramide, cisapride
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| drugs that increase gastric emptying | show 🗑
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| show | cisapride, bethanechol
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| __ in GERD is less efficacious than in PUD | show 🗑
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| esophagela healing __ for PPI as compared with H2A | show 🗑
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| show | visceral stimuli, chemoreceptor trigger zone, vestibular inpu
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| drug induced N/V | show 🗑
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| show | H2A, antacids
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| most practical for long-term treatment for N/V | show 🗑
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| serotonin antagonists are best for | show 🗑
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| serotonin antagonists are not effective for __ | show 🗑
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| show | Zofran, Kytril
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| show | serotonin antagonists
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| show | gastric stasis or CINV
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| example of a prokinetic agent | show 🗑
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| show | CINV
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| show | chemo induced nausea and vomiting
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| show | post-operative nausea and vomiting
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| show | CINV and PONV
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| show | decadron, prednisone
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| show | anticipatory N/V
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| examples of bezno's used for N/V | show 🗑
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| butyrophenones are best used for | show 🗑
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| example of butyrophenone used for N/V | show 🗑
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| show | Neurokinin-1 antagonists
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| drugs that induce diarrhea | show 🗑
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| show | withhold feeding (not for children)
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| pharmacologic treatment options for diarrhea | show 🗑
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| bacterial diarrhea (C. dif), Colitis, children <2, are contraindications for use of __ | show 🗑
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| show | 48 hours
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| show | loperamide
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| used for symptomatic relief, not very effective for sever acute diarrhea, not systemically absorbed (Kaopectate, FiberCon) | show 🗑
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| examples of antisecretory agent | show 🗑
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| common pathogens for traveler's diarrhea | show 🗑
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| show | prphylactic antibiotics
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| show | encourage 10g crude fiber in daily diet, 1 month trial
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| pharmacologic treatment options for constipation | show 🗑
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| bulk forming laxatives (metamucil) are best used for | show 🗑
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| show | saline laxatives (Magnesium Citrate, (MOM)
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| show | emollient laxatives (docusate(Colace))
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| not recommended for routine use, in the elderly, or children <6 years old. Coats stool for easier passage, inhibits colonic absorption of water, increase stool weight and decrease stool transit time. Take on empty stomach, not before bed | show 🗑
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| show | stimulants
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| anthraquinone stimulants | show 🗑
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| show | bisacodyl (dulcolax), phenolphthalein (removed from the marked due to carcinogenic capabilities)
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